1. Low ventilatory responsiveness to transient hypoxia or breath-holding predicts fast marathon performance in healthy middle-aged and older men.
- Author
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Paleczny B, Seredyński R, Wyciszkiewicz M, Nowicka-Czudak A, Łopusiewicz W, Adamiec D, Wiecha S, Mroczek D, Chmura P, Konefał M, Maćkała K, Chromik K, Pawlik D, Andrzejewski M, Chmura J, Ponikowski P, and Ponikowska B
- Subjects
- Aged, Athletes, Athletic Performance physiology, Autonomic Nervous System physiology, Blood Pressure physiology, Breath Holding, Chemoreceptor Cells physiology, Exercise physiology, Exercise Test, Heart physiology, Heart Rate, Hemodynamics physiology, Humans, Hypoxia metabolism, Male, Middle Aged, Prognosis, Hypoxia physiopathology, Marathon Running physiology, Oxygen Consumption physiology
- Abstract
The aim of this study was to test the utility of haemodynamic and autonomic variables (e.g. peripheral chemoreflex sensitivity [PCheS], blood pressure variability [BPV]) for the prediction of individual performance (marathon time and VO
2max ) in older men. The post-competition vasodilation and sympathetic vasomotor tone predict the marathon performance in younger men, but their prognostic relevance in older men remains unknown. The peripheral chemoreflex restrains exercise-induced vasodilation via sympathetically-mediated mechanism, what makes it a plausible candidate for the individual performance marker. 23 men aged ≥ 50 year competing in the Wroclaw Marathon underwent an evaluation of: resting haemodynamic parameters, PCheS with two methods: transient hypoxia and breath-holding test (BHT), cardiac barosensitivity, heart rate variability (HRV) and BPV, plasma renin and aldosterone, VO2max in a cardiopulmonary exercise test (CPET). All tests were conducted twice: before and after the race, except for transient hypoxia and CPET which were performed once, before the race. Fast marathon performance and high VO2max were correlated with: low ventilatory responsiveness to hypoxia (r = - 0.53, r = 0.67, respectively) and pre-race BHT (r = - 0.47, r = 0.51, respectively), (1) greater SD of beat-to-beat SBP (all p < 0.05). Fast performance was related with an enhanced pre-race vascular response to BHT (r = - 0.59, p = 0.005). The variables found by other studies to predict the marathon performance in younger men: post-competition vasodilation, sympathetic vasomotor tone (LF-BPV) and HRV were not associated with the individual performance in our population. The results suggest that PCheS (ventilatory response) predicts individual performance (marathon time and VO2max ) in men aged ≥ 50 yeat. Although cause-effect relationship including the role of peripheral chemoreceptors in restraining the post-competition vasodilation via the sympathetic vasoconstrictor outflow may be hypothesized to underline these findings, the lack of correlation between individual performance and both, the post-competition vasodilation and the sympathetic vasomotor tone argues against such explanation. Vascular responsiveness to breath-holding appears to be of certain value for predicting individual performance in this population, however.- Published
- 2021
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