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A diblock copolymer containing a strapped calix[4]pyrrole-based ion pair recognition subunit has been synthesized via RAFT polymerization. As prepared, the polymer is hydrophobic and devoid of any particular morphological form. However, upon ion pair complexation, the copolymer self-assembles to generate reverse micelles in organic media. The reverse micelles formed in this way may be used to extract alkali cation and cesium halide anion salts from an aqueous source into an organic receiving phase. The polymer proved more effective as an extractant than the corresponding free ion pair receptor.

Gels formed from commercially available polyvinyl alcohol (PVA) and 1,4-benzene diboronic acid (BdBA) in DMSO absorb NaOH efficiently from a bulk aqueous solution decreasing its pH.

An anthracene-functionalized, long-tailed calix[4]pyrrole 1, containing both an anion-recognition site and cation-recognition functionality, has been synthesized and fully characterized. Upon ion pair complexation with FeF 2 , receptor 1 self-assembles into multimicelles in aqueous media. This aggregation process is ascribed to a change in polarity from nonpolar to amphiphilic induced upon concurrent anion and cation complexation and permits molecular recognition-based control over chemical morphology under interfacial conditions. Photoirradiation of the micelles serves to cross-link the anthracene units thus stabilizing the aggregates. The combination of ion pair recognition, micelle formation, and cross-linking can be used to extract FeF 2 ion pairs from bulk aqueous solutions. The present work helps illustrate how molecular recognition and self-assembly may be used to control the chemistry of extractants at interfaces.

This research examined whether military service members' deployment-related trauma exposure, posttraumatic stress disorder (PTSD) symptoms, and experiential avoidance are associated with their observed levels of positive social engagement, social withdrawal, reactivity-coercion, and distress avoidance during postdeployment family interaction. Self reports of deployment related trauma, postdeployment PTSD symptoms, and experiential avoidance were collected from 184 men who were deployed to the Middle East conflicts, were partnered, and had a child between 4 and 13 years of age. Video samples of parent-child and partner problem solving and conversations about deployment issues were collected, and were rated by trained observers to assess service members' positive engagement, social withdrawal, reactivity-coercion, and distress avoidance, as well as spouse and child negative affect and behavior. Service members' experiential avoidance was reliably associated with less observed positive engagement and more observed withdrawal and distress avoidance after controlling for spouse and child negative affect and behavior during ongoing interaction. Service members' experiential avoidance also diminished significant associations between service members' PTSD symptoms and their observed behavior. The results are discussed in terms of how service members' psychological acceptance promotes family resilience and adaption to the multiple contextual challenges and role transitions associated with military deployment. Implications for parenting and marital interventions are described., ((c) 2016 APA, all rights reserved).)

Background: Lower extremity injuries are common in athletes. Valid tests to assess for risk of injury that are easily performed during a preparticipation sports physical examination are lacking. Two-dimensional (2D) analysis of the drop-jump test can identify athletes at risk, but it is too expensive and cumbersome to use in this setting., Objective: To identify if those who perform a "positive"(abnormal postures) single leg squat (SLS) test also exhibit greater "dynamic valgus" on the 2D drop-jump test. Our secondary purpose was to assess whether group differences in gender, age, or body mass index are evident between those who exhibit a positive SLS test result versus a negative SLS test result. Also, we wanted to determine any gender differences with the 2D drop-jump test., Design: A cross-sectional study., Setting: Private practice, preparticipation sports physical examinations., Participants: A total of 142 middle school and high school athletes., Methods: Participants performed a SLS test and a drop-jump test during their preparticipation sports physical examination. Individuals were partitioned into groups based on the outcome of their SLS test (positive SLS group versus negative SLS group). Independent sample t-tests were used to evaluate SLS group differences in the drop-jump test, age, and body mass index, and the χ(2) test was used to evaluate SLS group differences in gender (P ≤ .05)., Main Outcome Measurements: The SLS test and drop-jump test., Results: Seventy-three of the 142 athletes (51%) had a positive SLS test result, whereas 69 athletes (49%) had a negative SLS test result. Individuals in the positive SLS group had a significantly lower knee-hip ratio), indicative of greater dynamic knee valgus, than did those in the negative SLS group (P = .02). Individual characteristics between SLS groups including gender, age, and body mass index were similar., Conclusion: The SLS test is a reasonable tool to use in preparticipation sports physical examinations to assess for dynamic knee valgus and the potential risk of lower extremity injury., (Copyright © 2015 American Academy of Physical Medicine and Rehabilitation. Published by Elsevier Inc. All rights reserved.)

Nano-sized polymersomes functionalized with peptides or proteins are being increasingly studied for targeted delivery of diagnostic and therapeutic molecules. Earlier computational studies have suggested that ellipsoidal nanoparticles, compared to spherical ones, display enhanced binding efficiency with target cells, but this has not yet been experimentally validated. We hypothesize that hydrophilic polymer chains coupled to vesicle-forming polymers would result in ellipsoidal polymersomes. In addition, ellipsoidal polymersomes modified with cell adhesion peptides bind with target cells more actively than spherical ones. We examine this hypothesis by substituting polyaspartamide with octadecyl chains and varying numbers of poly(ethylene glycol) (PEG) chains. Increasing the degree of substitution of PEG from 0.5 to 1.0 mol% drives the polymer to self-assemble into an ellipsoidal polymersome with an aspect ratio of 2.1. Further modification of these ellipsoidal polymersomes with peptides containing an Arg-Gly-Asp sequence (RGD peptides) lead to a significant increase in the rate of association and decrease in the rate of dissociation with a substrate coated with α v β 3 integrins. In addition, in a circulation-mimicking flow, the ellipsoidal polymersomes linked with RGD peptides adhere to target tissues more favorably than their spherical equivalents do. Overall, the results of this study will greatly serve to improve the efficiency of targeted delivery of a wide array of polymersomes loaded with various biomedical modalities.

This report examines how the relative attractor strengths of children's display of three emotion states, anger, sadness/fear, and neutral-engaged, are associated with exposure to maternal negative affect and care giving disruptions, and to child antisocial behavior and depression. Exposure to negative maternal affect was associated with a weaker attractor state for sadness or fear displays relative to those for anger and neutral-engaged displays. Exposure to care giving disruptions was associated with stronger attractor strength for anger and sadness/fear relative to that for neutral-engaged. Overt and covert antisocial behaviors were associated with weaker attractor states for sadness/fear displays relative that for the neutral-engaged displays. Overt antisocial behavior was associated with a stronger attractor state for anger displays relative to that for neutral-engaged displays, and covert antisocial behavior with a weaker attractor state for fear/sadness displays relative to that for neutral-engaged displays. Child depressive symptoms were marginally associated with a stronger attractor state for fear/sadness displays relative to neutral-engaged. The data suggest the attractor strengths for emotion display states are affected by social experience and that between-individual risk for various forms of psychopathology is related to the relative intra-individual attractor strength of various emotion displays in a multi-state emotion display system.

Recent advances in microfluidics have enabled the molecular-level study of polymer dynamics using single DNA chains. Single polymer studies based on fluorescence microscopy allow for the direct observation of non-equilibrium polymer conformations and dynamical phenomena such as diffusion, relaxation, and molecular stretching pathways in flow. Microfluidic devices have enabled the precise control of model flow fields to study the non-equilibrium dynamics of soft materials, with device geometries including curved channels, cross-slots, and microfabricated obstacles and structures. This review explores recent microfluidic systems that have advanced the study of single polymer dynamics, while identifying new directions in the field that will further elucidate the relationship between polymer microstructure and bulk rheological properties.

Over the last 15 years, double stranded DNA (dsDNA) has been used as a model polymeric system for nearly all single polymer dynamics studies. However, dsDNA is a semiflexible polymer with markedly different molecular properties compared to flexible chains, including synthetic organic polymers. In this work, we report a new system for single polymer studies of flexible chains based on single stranded DNA (ssDNA). We developed a method to synthesize ssDNA for fluorescence microscopy based on rolling circle replication, which generates long strands (>65 kb) of ssDNA containing "designer" sequences, thereby preventing intramolecular base pair interactions. Polymers are synthesized to contain amine-modified bases randomly distributed along the backbone, which enables uniform labelling of polymer chains with a fluorescent dye to facilitate fluorescence microscopy and imaging. Using this approach, we synthesized ssDNA chains with long contour lengths (>30 μm) and relatively low dye loading ratios (~1 dye per 100 bases). In addition, we used epifluorescence microscopy to image single ssDNA polymer molecules stretching in flow in a microfluidic device. Overall, we anticipate that ssDNA will serve as a useful model system to probe the dynamics of polymeric materials at the molecular level.

A 72-year-old woman presented with a recurrent proximal aortic true aneurysm 7 years after an abdominal aortic aneurysmectomy. It was complicated by a contained rupture into the right psoas. The repair was successfully realized through a thoraco-abdominal approach. A tube graft was interposed between the proximal aorta and the old graft, associated with the reimplantation of the renal arteries. A systemic follow-up of abdominal aortic grafts by reliable diagnostic methods is advocated to provide a timely and appropriate surgical treatment of this major complication.