9 results on '"Bode I"'
Search Results
2. Navigating the Future of Organisational Health Services Research in Germany and beyond: a Position Paper.
- Author
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Ansmann L, Nöst S, Körner M, Auschra C, Bal R, Böddeker M, Bode I, Braithwaite J, Breidenbach C, Coors M, Demirer I, Exworthy M, Harst L, Heuser C, Hoffmann J, Köberlein-Neu J, Krajic K, Maniatopoulos G, Mannion R, Möhler R, Pfaff H, Rieger MA, Rind E, Helge Schnack MA, Anke Wagner MA, Weigl M, Wensing M, Wiig S, Wild E, Wilhelm H, Wirtz M, and Götz K
- Subjects
- Germany, Organizational Objectives, Health Services Research trends, Forecasting
- Abstract
Background: Recent analyses have shown that in health services research in Germany, healthcare organisations are often considered primarily as a study setting, without fully taking their complex organisational nature into account, neither theoretically nor methodologically. Therefore, an initiative was launched to analyse the state of Organisational Health Services Research (OHSR) in Germany and to develop a strategic framework and road map to guide future efforts in the field. This paper summarizes positions that have been jointly developed by consulting experts from the interdisciplinary and international scientific community., Methods: In July 2023, a scoping workshop over the course of three days was held with 32 (inter)national experts from different research fields centred around OHSR topics using interactive workshop methods. Participants discussed their perspectives on OHSR, analysed current challenges in OHSR in Germany and developed key positions for the field's development., Results: The seven agreed-upon key positions addressed conceptual and strategic aspects. There was consensus that the field required the development of a research agenda that can guide future efforts. On a conceptual level, the need to address challenges in terms of interdisciplinarity, terminology, organisation(s) as research subjects, international comparative research and utilisation of organisational theory was recognized. On a strategic level, requirements with regard to teaching, promotion of interdisciplinary and international collaboration, suitable funding opportunities and participatory research were identified., Conclusions: This position paper seeks to serve as a framework to support further development of OHSR in Germany and as a guide for researchers and funding organisations on how to move OHSR forward. Some of the challenges discussed for German OHSR are equally present in other countries. Thus, this position paper can be used to initiate fruitful discussions in other countries., Competing Interests: LA ist Vorstandsmitglied der DGMS und des DNVF. Sie ist Mitglied des Editorial Boards des Journal of Health Care Services and Implementation. JB erhält Fördermittel für mehrere OVF-Projekte in Australien und Europa. ME ist Vorsitzender der Society for Studies in Organizing Healthcare (SHOC). Die Arbeit des Instituts für Arbeitsmedizin, Sozialmedizin und Versorgungsforschung, Universitätsklinikum Tübingen, wird durch einen zweckungebundenen Zuschuss des Arbeitgeberverbands der Metall- und Elektroindustrie Baden-Württemberg (Südwestmetall) unterstützt. Die übrigen Autor*innen erklären, dass keine Interessenkonflikte bestehen., (The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).)
- Published
- 2024
- Full Text
- View/download PDF
3. Biomarkers in Thyroid Cancer: Emerging Opportunities from Non-Coding RNAs and Mitochondrial Space.
- Author
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Cabané P, Correa C, Bode I, Aguilar R, and Elorza AA
- Subjects
- Humans, RNA, Untranslated genetics, RNA, Long Noncoding genetics, MicroRNAs genetics, Prognosis, Biomarkers, Tumor genetics, Thyroid Neoplasms genetics, Thyroid Neoplasms diagnosis, Thyroid Neoplasms pathology, DNA, Mitochondrial genetics, Mitochondria metabolism, Mitochondria genetics
- Abstract
Thyroid cancer diagnosis primarily relies on imaging techniques and cytological analyses. In cases where the diagnosis is uncertain, the quantification of molecular markers has been incorporated after cytological examination. This approach helps physicians to make surgical decisions, estimate cancer aggressiveness, and monitor the response to treatments. Despite the availability of commercial molecular tests, their widespread use has been hindered in our experience due to cost constraints and variability between them. Thus, numerous groups are currently evaluating new molecular markers that ultimately will lead to improved diagnostic certainty, as well as better classification of prognosis and recurrence. In this review, we start reviewing the current preoperative testing methodologies, followed by a comprehensive review of emerging molecular markers. We focus on micro RNAs, long non-coding RNAs, and mitochondrial (mt) signatures, including mtDNA genes and circulating cell-free mtDNA. We envision that a robust set of molecular markers will complement the national and international clinical guides for proper assessment of the disease.
- Published
- 2024
- Full Text
- View/download PDF
4. Artificial Intelligence Technologies and Practical Normativity/Normality: Investigating Practices beyond the Public Space.
- Author
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Bode I and Huelss H
- Abstract
This essay examines how artificial intelligence (AI) technologies may shape international norms. Following a brief discussion of the ways in which AI technologies pose new governance questions, we reflect on the extent to which norm research in the discipline of International Relations (IR) is equipped to understand how AI technologies shape normative substance. Norm research has typically focused on the impact and failure of norms, offering increasingly diversified models of norm contestation, for instance. But present research has two shortcomings: a near-exclusive focus on modes and contexts of norm emergence and constitution that happen in the public space; and a focus on the workings of a pre-set normativity (ideas of oughtness and justice) that stands in an unclear relationship with normality (ideas of the standard, the average) emerging from practices. Responding to this, we put forward a research programme on AI and practical normativity/normality based on two pillars: first, we argue that operational practices of designing and using AI technologies typically performed outside of the public eye make norms; and second, we emphasise the interplay of normality and normativity as analytically influential in this process. With this, we also reflect on how increasingly relying on AI technologies across diverse policy domains has an under-examined effect on the exercise of human agency. This is important because the normality shaped by AI technologies can lead to forms of non-human generated normativity that risks replacing conventional models about how norms matter in AI-affected policy domains. We close with sketching three future research streams. We conclude that AI technologies are a major, yet still under-researched, challenge for understanding and studying norms. We should therefore reflect on new theoretical perspectives leading to insights that are also relevant for the struggle about top-down forms of AI regulation., Competing Interests: No competing interests were disclosed., (Copyright: © 2024 Bode I and Huelss H.)
- Published
- 2024
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- View/download PDF
5. Increased Likelihood of Detecting Ebola Virus RNA in Semen by Using Sample Pelleting.
- Author
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Bozman CM, Fallah M, Sneller MC, Freeman C, Fakoli LS 3rd, Shobayo BI, Dighero-Kemp B, Reilly CS, Kuhn JH, Bolay F, Higgs E, and Hensley LE
- Subjects
- Humans, RNA, Viral, Semen, Survivors, Ebolavirus genetics, Hemorrhagic Fever, Ebola
- Abstract
Ebola virus RNA can reside for months or years in semen of survivors of Ebola virus disease and is probably associated with increased risk for cryptic sexual transmission of the virus. A modified protocol resulted in increased detection of Ebola virus RNA in semen and improved disease surveillance.
- Published
- 2021
- Full Text
- View/download PDF
6. [The sirtuin family of proteins: the role in the aging processes and regulation of cell metabolism.]
- Author
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Bode II, Medvedev DS, Kvetnoy IM, and Polyakova VO
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- Humans, Inflammation pathology, Metabolic Syndrome pathology, Neoplasms pathology, Neurodegenerative Diseases pathology, Aging, Sirtuins physiology
- Abstract
In recent years, the key role of sirtuins in the regulation of the most important cellular processes has been established. Sirtuins are involved in histone deacetylation, regulation of fat and glucose metabolism. Violations of their synthesis and secretion can induce carcinogenesis, aging and cell death. The wide range of processes in which sirtuins are involved indicates their possible role in the pathogenesis of many diseases including metabolic syndrome, neurodegenerative diseases, inflammation associated diseases and tumor growth. All of these diseases are associated with aging. In this article, we analyze the existing data on sirtuins and their role in the pathogenesis of aging, as well as their possible verification as markers for the diagnosis of age-related diseases and as targets of geriatric therapy and prevention.
- Published
- 2019
7. Reflective practices at the Security Council: Children and armed conflict and the three United Nations.
- Author
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Bode I
- Abstract
The United Nations Security Council passed its first resolution on children in armed conflict in 1999, making it one of the oldest examples of Security Council engagement with a thematic mandate and leading to the creation of a dedicated working group in 2005. Existing theoretical accounts of the Security Council cannot account for the developing substance of the children and armed conflict agenda as they are macro-oriented and focus exclusively on states. I argue that Security Council decision-making on thematic mandates is a productive process whose outcomes are created by and through practices of actors across the three United Nations: member states (the first United Nations), United Nations officials (the second United Nations) and non-governmental organizations (the third United Nations). In presenting a practice-based, micro-oriented analysis of the children and armed conflict agenda, the article aims to deliver on the empirical promise of practice theories in International Relations. I make two contributions to practice-based understandings: first, I argue that actors across the three United Nations engage in reflective practices of a strategic or tactical nature to manage, arrange or create space in Security Council decision-making. Portraying practices as reflective rather than as only based on tacit knowledge highlights how actors may creatively adapt their practices to social situations. Second, I argue that particular individuals from the three United Nations are more likely to become recognized as competent performers of practices because of their personality, understood as plural socialization experiences. This adds varied individual agency to practice theories that, despite their micro-level interests, have focused on how agency is relationally constituted.
- Published
- 2018
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8. Molecular mechanisms of plasminogen activation: bacterial cofactors provide clues.
- Author
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Parry MA, Zhang XC, and Bode I
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- Amino Acid Sequence, Fibrinolysin metabolism, Humans, Metalloendopeptidases chemistry, Molecular Sequence Data, Peptide Fragments metabolism, Plasminogen chemistry, Plasminogen Activators chemistry, Streptokinase chemistry, Streptokinase metabolism, Fibrinolysin antagonists & inhibitors, Fibrinolysin chemistry, Metalloendopeptidases metabolism, Peptide Fragments chemistry, Plasminogen metabolism, Plasminogen Activators metabolism
- Abstract
Plasminogen activation is a key event in the fibrinolytic system that results in the dissolution of blood clots, and also promotes cell migration and tissue remodelling. The recent structure determinations of microplasmin in complex with the bacterial plasminogen activators staphylokinase and streptokinase have provided novel insights into the molecular mechanisms of plasminogen activation and cofactor function. These bacterial proteins are cofactor molecules that contribute to exosite formation and enhance the substrate presentation to the enzyme. At the same time, they modulate the specificity of plasmin towards substrates and inhibitors, making a 'specificity switch' possible.
- Published
- 2000
- Full Text
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9. [Studies of the ascorbic acid content of some products of plant nature].
- Author
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Petrescu Z, Cocişiu M, Galuşinschi A, and Bode I
- Subjects
- Ascorbic Acid analysis, Edible Grain analysis, Food Analysis, Fruit analysis, Vegetables analysis
- Published
- 1970
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