1. Modelling lung diffusion-perfusion limitation in mechanically ventilated SARS-CoV-2 patients.
- Author
-
Miserocchi G, Rezoagli E, Muñoz-Del-Carpio-Toia A, Paricahua-Yucra LP, Zubieta-DeUrioste N, Zubieta-Calleja G, and Beretta E
- Abstract
This is the first study to describe the daytime evolution of respiratory parameters in mechanically ventilated COVID-19 patients. The data base refers to patients hospitalised in the intensive care unit (ICU) at Arequipa Hospital (Peru, 2335 m) in 2021. In both survivors (S) and non-survivors (NS) patients, a remarkable decrease in respiratory compliance was observed, revealing a proportional decrease in inflatable alveolar units. The S and NS patients were all hyperventilated and their SatO
2 was maintained at >90%. However, while S remained normocapnic, NS developed progressive hypercapnia. We compared the efficiency of O2 uptake and CO2 removal in the air blood barrier relying on a model allowing to partition between diffusion and perfusion limitations to gas exchange. The decrease in O2 uptake was interpreted as diffusion limitation, while the impairment in CO2 removal was modelled by progressive perfusion limitation. The latter correlated with the increase in positive end-expiratory pressure (PEEP) and plateau pressure (Pplat), leading to capillary compression, increased blood velocity, and considerable shortening of the air-blood contact time., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision., (Copyright © 2024 Miserocchi, Rezoagli, Muñoz-Del-Carpio-Toia, Paricahua-Yucra, Zubieta-DeUrioste, Zubieta-Calleja and Beretta.)- Published
- 2024
- Full Text
- View/download PDF