1. Depression and anxiety in patients with AL amyloidosis as assessed by the SF-36 questionnaire: experience in 1226 patients .
- Author
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Shu J, Lo S, Phillips M, Sun F, Seldin DC, Berenbaum I, Berk JL, and Sanchorawala V
- Subjects
- Adult, Age Factors, Aged, Alcohol Drinking physiopathology, Amyloidosis complications, Amyloidosis physiopathology, Amyloidosis psychology, Anxiety complications, Anxiety physiopathology, Anxiety psychology, Cardiomyopathies complications, Cardiomyopathies physiopathology, Cardiomyopathies psychology, Depression complications, Depression physiopathology, Depression psychology, Female, Humans, Male, Marital Status, Middle Aged, Quality of Life psychology, Risk Factors, Sex Factors, Smoking physiopathology, Surveys and Questionnaires, Amyloidosis diagnosis, Anxiety diagnosis, Cardiomyopathies diagnosis, Depression diagnosis
- Abstract
Background: Our study examines depression and anxiety in patients with immunoglobulin light chain (AL) amyloidosis, and determines the associations between the mental health problems and patient characteristics (age, gender, race, marital status, alcohol consumption, smoking status and cardiac involvement)., Methods: Patients with AL amyloidosis who completed the 36-item Short Form General Health Survey (SF-36) during initial evaluation at a single center were studied. The SF-36 included assessments of depression, anxiety, role limitation due to emotional problems and the mental health subscale score., Results: From 1226 patients with AL amyloidosis, 37.0% reported depression and 46.7% reported anxiety. Patients with cardiac amyloidosis reported more anxiety (odds ratio (OR) = 1.29, 95% confidence interval (CI) 1.03-1.61) and role limitation due to emotional problems (OR = 1.32, 95%CI 1.05-1.65). No significant association between cardiac involvement and depression was found (OR = 1.22, 95%CI 0.97-1.54). Men reported less anxiety (OR = 0.72, 95%CI 0.57-0.91). Patients ≥65 years experienced greater role limitation (OR = 1.36, 95%CI 1.08-1.71). Smokers (p = 0.019) and women (p = 0.006) scored lower on mental health subscales., Conclusions: Many patients with AL amyloidosis suffer from depression, anxiety and functional limitations. Psychiatric assessment and treatment is important, and further research is needed to clarify the long-term effects of depression and anxiety in AL amyloidosis. This current study was registered in ClinicalTrials.gov as NCT00898235.
- Published
- 2016
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