Search

We studied the influence of correction of iron metabolism and erythron characteristics to normal values in latent iron-deficiency states and mild iron deficiency anemia (IDA) with a hemoglobin level of 130-110 g/l on clinical manifestations of the concomitant coronary heart disease (CHD). The patients were 71 men aged 51.5 +/- 1.1 yr; the control group was comprised 18 age-matched healthy men. CHD and anemia were diagnosed as recommended by RSSC and WHO respectively. Clinical manifestations of both pathologies were compared before and after correction of iron metabolism and erythron characteristics using Sorbifer Durules (Egis, Hungary) in combination with pharmacotherapy ofcardiovascular disorders. Characteristics of iron metabolism and erythron were determined using a Stet Fax 3300 analizer and Vital reagent kits. Sorbifer (200 mg Fe) was given daily for 3 weeks with relevant dietary recommendations. All patients with latent iron-deficiency showed normalization of iron metabolism and those with IDA of both iron metabolism and erythron. In CHD patients, these effects were accompanied by a decrease in the frequency, duration, and intensity of angina, reduced requirement of nitroglycerin, increased tolerance of physical exercises. Also, the severity of co-morbid clinical manifestations (oedema, dyspnoea, palpitation) and heart rate decreased.

Aim: To study central hemodynamics response to bicycle exercise with optimal pedalling rate (OPR) and in free-choice regimen of pedalling as regards the initial pedalling rate in postmyocardial infarction (PMI) patients on sanatorium treatment., Materials and Methods: Bicycle ergometry and tetrapolar rheography examinations were performed in 124 PMI male patients. Bicycle exercise was carried out in three regimens: a) optimal pedalling rate (1), b) muscular load chosen by the patient at the first training kept further for daily training (2), c) free-choice daily load (3)., Results: In OPR 30 and 45 rpm, patients on regimen 3 improved their myocardial contractility both at rest and exercise. In OPR 60 rpm, exercise in regimen 1 was more effective. Regimen 2 was not effective., Conclusion: Hemodynamic effects were most pronounced (improved myocardial contractility in more effective cardiac performance) in the regimen of OPR 60 rpm.