1. Prognostic and survival factors in head and neck extra-nodal non-Hodgkin's lymphoma.
- Author
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Bello-Castro A, Mosquera-Orgueira A, Gude-Smpedro F, Varela-Aneiros I, Seoane-Romero J, Martin-Biedma B, and Castelo-Baz P
- Subjects
- Humans, Male, Female, Middle Aged, Retrospective Studies, Prognosis, Aged, Adult, Aged, 80 and over, Risk Factors, Head and Neck Neoplasms therapy, Head and Neck Neoplasms pathology, Head and Neck Neoplasms mortality, Lymphoma, Non-Hodgkin pathology, Lymphoma, Non-Hodgkin therapy, Lymphoma, Non-Hodgkin mortality, Lymphoma, Non-Hodgkin drug therapy, Neoplasm Staging
- Abstract
Objective: To make a clinical-biological characterization of this pathology and assess the survival of these patients and the associated prognostic factors., Study Design: A retrospective observational study was designed to identify primary extranodal non-Hodgkin lymphomas of the head and neck diagnosed between January 1, 2005, and January 1, 2016. Cases were considered if they presented with a single tumor in situ or if the extranodal component was clinically predominant., Results: A total of 145 patients were included. Localized stages (I-II) were present in 69.3%. Overall, 91.8% were B-cell phenotype, with diffuse large B-cell lymphoma being the most frequent. Overall, 78% of patients were treated with immunochemotherapy. The overall survival at 3 and 5 years was 75% and 73%, respectively. Adverse prognostic factors were: low hemoglobin, elevated ß2-microglobulin, and lactate dehydrogenase (LDH) levels, Eastern Cooperative Oncology Group (ECOG), stage III/IV, and B symptomatology at diagnosis. The progression-free survival at 3 and 5 years was 71% and 68%. Risk factors for relapse were high ß2-microglobulin, high LDH, and stage III-IV at diagnosis., Conclusions: These pathologies show a good response to treatment with immuno-polychemotherapy. Factors associated with a worse prognosis included low hemoglobin, elevated levels of ß2-microglobulin and LDH, elevated ECOG, stage III/IV, and B symptomatology at diagnosis., Competing Interests: Declarations of Interest The authors declare that they have no competing interests., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
- Published
- 2025
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