1. Antitumor activity of essential oils-based nanostructured lipid carriers on prostate cancer cells.
- Author
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Santos Pimentel L, Sommerfeld S, Fernanda de Sousa Braga P, Flores Coleto A, Beatriz Fonseca B, Machado Bastos L, Ricardo Goulart L, and Nunes de Morais Ribeiro L
- Subjects
- Male, Humans, Animals, Chick Embryo, Antineoplastic Agents pharmacology, Antineoplastic Agents chemistry, Antineoplastic Agents administration & dosage, Cell Line, Tumor, PC-3 Cells, Cell Movement drug effects, Xenograft Model Antitumor Assays, Drug Stability, Prostatic Neoplasms drug therapy, Prostatic Neoplasms pathology, Oils, Volatile pharmacology, Oils, Volatile chemistry, Oils, Volatile administration & dosage, Lipids chemistry, Nanostructures chemistry, Drug Carriers chemistry, Cell Proliferation drug effects
- Abstract
Prostate cancer (PCa) is the second most frequent malignancy in men worldwide. Essential oils (EOs) are natural products which can act in cancer suppression by several mechanisms. In this work, a nanotechnological approach was used to develop and evaluate the antineoplastic effects of EOs loaded by nanostructured lipid carriers (NLCs). Three different NLC systems composed of cinnamon, sage or thyme EOs were optimized using factorial design (2
3 ). The optimal formulations were characterized in terms of biophysical parameters, structure, stability, in vivo safety and efficacy. All optimized NLC formulations exhibited excellent structural properties and stability over a year (25 °C). They proved to be in vitro and in vivo biocompatible on PNT2 normal prostate cells and on chicken embryos (CE), respectively. In PC3 PCa cells, optimized NLCs inhibited cell proliferation and migration and changed its morphology. In CE xenograft tumor, NLCs have inhibited tumor growth and angiogenesis. The results from this work suggested that all developed EO-based NLC formulations had their stability improved while the biological activity remains unchanged., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)- Published
- 2024
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