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On September 24, 2022, Post-Tropical Hurricane Fiona made landfall in Atlantic Canada and caused unprecedented damages to the coastal communities and ecosystems therein. The aftermath triggered local government and communities in Prince Edward Island (PEI), Canada to rethink current policies and practices for coastal protection in the context of climate change. This historic hazard represents the escalating frequency and intensity of extreme weather events that globally threaten coastal regions, accelerating coastal erosion and endangering communities. This study employs landcover-based detection to assess rapid storm impact of Fiona on coastline of PEI using Sentinel-2 satellite images, to gauge the efficacy of landcover-based detection and quantify storm-induced coastal environmental changes. Our results indicate that, following Fiona, over 51 km 2 coastal land loss due to the erosion at beach foreshore and inundation at tidal flat, and over 11 km 2 sand dune loss mainly on the PEI north shore. This constitutes a 3.5 % loss of coastal land resources within the 1798 km 2 PEI coastal zone. Fiona also caused over 194 km 2 area in coastal buffer zone showed temporal fluid-mud from the eroded sediments of sand dunes, cliffs, and tidal flats, suggesting the significant sediment loss from vertical structures in addition to the direct retreat. The landcover-based method can be regarded as a valuable tool for the storm impacts on coastal environments. Based on the coastal change pattern, more sustainable coastal protection and adaptation measures should be developed, focusing on reducing hydrodynamic intensity and improving erosion capacity, with consideration of the increasing likelihood of more intense and frequent storm events in a warming climate., Competing Interests: Declaration of competing interest There is no competing interest., (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)

Oysters are enriched with high-quality protein and are widely known for their exquisite taste. The production of oysters plays an important role in the local economies of coastal communities in many countries, including Atlantic Canada, because of their high economic value. However, because of the changing climatic conditions in recent years, oyster aquaculture faces potentially negative impacts, such as increasing water acidification, rising water temperatures, high salinity, invasive species, algal blooms, and other environmental factors. Although a few isolated effects of climate change on oyster aquaculture have been reported in recent years, it is not well understood how climate change will affect oyster aquaculture from a systematic perspective. In the first part of this study, we present a systematic review of the impacts of climate change and some key environmental factors affecting oyster production on a global scale. The study also identifies knowledge gaps and challenges. In addition, we present key research directions that will facilitate future investigations., Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)

Protein aggregates are a hallmark of Alzheimer's disease (AD). Extensive studies have focused on β-amyloid plaques and Tau tangles. Here, we illustrate a novel source of protein aggregates in AD neurons from organelle off-target proteins. Bax is a mitochondrial pore-forming pro-death protein. What happens to Bax if it fails to target mitochondria? We previously showed that a mitochondrial target-deficient alternatively spliced variant, Bax∆2, formed large cytosolic protein aggregates and triggered caspase 8-mediated cell death. Bax∆2 protein levels were low in most normal organs and the proteins were quickly degraded in cancer. Here, we found that 85% of AD patients had Bax∆2 required alternative splicing. Increased Bax∆2 proteins were mostly accumulated in neurons of AD-susceptible brain regions. Intracellularly, Bax∆2 aggregates distributed independently of Tau tangles. Interestingly, Bax∆2 aggregates triggered the formation of stress granules (SGs), a large protein-RNA complex involved in AD pathogenesis. Although the functional domains required for aggregation and cell death are the same as in cancer cells, Bax∆2 relied on SGs, not caspase 8, for neuronal cell death. These results imply that the aggregation of organelle off-target proteins, such as Bax∆2, broadens the scope of traditional AD pathogenic proteins that contribute to the neuronal stress responses and AD pathogenesis.

Crop yields are adversely affected by climate change; therefore, it is crucial to develop climate adaptation strategies to mitigate the impacts of increasing climate variability on the agriculture system to ensure food security. As one of the largest potato-producing provinces in Canada, Prince Edward Island (PEI) has recently experienced significant instability in potato production. PEI's local farmers and stakeholders are extremely concerned about the prospects for the future of potato farming industries in the context of climate change. This study aims to use the Decision Support System for Agrotechnology Transfer (DSSAT) potato model to simulate future potato yields under the Coupled Model Intercomparison Project Phase 6 (CMIP6) climate scenarios (including SSP1-1.9, SSP1-2.6, SSP2-4.5, SSP3-7.0, and SSP5-8.5). The study evaluates the combined effects of changing climatic conditions at local scales (i.e., warming temperature and changing precipitation patterns) and increasing carbon dioxide (CO 2 ) concentration in the atmosphere. The results indicate future significant declines in potato yield in PEI under the current farming practices. In particular, under the high-emission scenarios (e.g., SSP3-7.0 and SSP5-8.5), the potato yield in PEI would decline by 48% and 60% in the 2070s and by 63% and 80% by 2090s; even under the low-emission scenarios (i.e., SSP1-1.9 and SSP1-2.6), the potato yield in PEI would still decline by 6-10%. This implies that it is important to develop effective climate adaptation measures (e.g., adjusting farming practices and introducing supplemental irrigation plans) to ensure the long-term sustainability of potato production in PEI.

The pro-apoptotic Bax isoform Bax∆2 was originally discovered in cancer patients with a microsatellite guanine deletion (G8 to G7). This deletion leads to an early stop codon; however, when combined with the alternative splicing of exon 2, the reading frame is restored allowing production of a full-length protein (Bax∆2). Unlike the parental Baxα, Bax∆2 triggers apoptosis through a non-mitochondrial pathway and the expression in human tissues was unknown. Here, we analyzed over 1000 tissue microarray samples from 13 different organs using immunohistochemistry. Bax∆2-positive cells were detected in all examined organs at low rates (1-5%) and mainly scattered throughout the connective tissues. Surprisingly, over 70% of normal colon samples scored high for BaxΔ2-positive staining. Only 7% of malignant colon samples scored high, with most high-grade tumors being negative. A similar pattern was observed in most organs examined. We also showed that both Baxα and Bax∆2 can co-exist in the same cells. Genotyping showed that the majority of Bax∆2-positive normal tissues contain no G7 mutation, but an unexpected high rate of G9 was observed. Although the underlying mechanism remains to be explored, the inverse correlation of Bax∆2 expression with tissue malignancy suggests that it may have a clinical implication in cancer development and treatment.