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1. The incidence of recurrent herpes simplex and herpes zoster infection during treatment with arsenic trioxide.

Author

Nouri K, Ricotti CA Jr, Bouzari N, Chen H, Ahn E, and Bach A

Subjects
Aged, Antineoplastic Agents therapeutic use, Arsenic Trioxide, Arsenicals therapeutic use, Colonic Neoplasms drug therapy, Female, Herpes Simplex pathology, Herpes Zoster pathology, Humans, Male, Multiple Myeloma drug therapy, Oxides therapeutic use, Recurrence, Antineoplastic Agents adverse effects, Arsenicals adverse effects, Herpes Simplex chemically induced, Herpes Zoster chemically induced, Oxides adverse effects
Abstract

We report the incidence of varicella zoster virus (VZV) and herpes simplex virus (HSV) infection in patients with multiple myeloma and colon cancer who were treated with arsenic trioxide for their disease. In this report, we discuss the effects of arsenic on immune system, and suggest arsenic compounds as a possible predisposing factor for viral reactivation in these patients.

Published
2006

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