1. Initial Diagnosis and Treatment of Low-Risk Gestational Trophoblastic Neoplasia.
- Author
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Alimena S, Elias KM, Horowitz NS, and Berkowitz RS
- Abstract
Gestational trophoblastic neoplasia (GTN) is a rare form of cancer that is treated according to the World Health Organization (WHO) risk score, which predicts responsiveness to single-agent chemotherapy. Patients with WHO risk scores ≤6 have low-risk GTN, for which cure rates near 100%. Most women with low-risk GTN will respond to single-agent chemotherapy, which is given with either methotrexate or dactinomycin, and allows women to retain their fertility. This article also discusses less common treatment paradigms including second dilation and curettage and hysterectomy, as well as the emerging role of immunotherapy in managing low-risk GTN., Competing Interests: Disclosure There are no financial or commercial conflicts of interest for any of the authors., (Copyright © 2024 Elsevier Inc. All rights reserved.)
- Published
- 2024
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