1. Cross-Neutralization between Human and African Bat Mumps Viruses.
- Author
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Katoh H, Kubota T, Ihara T, Maeda K, Takeda M, and Kidokoro M
- Subjects
- Adolescent, Adult, Animals, Cell Line, Chiroptera, Chlorocebus aethiops, Cricetulus, Democratic Republic of the Congo epidemiology, Female, Gene Expression, HN Protein genetics, HN Protein immunology, Host Specificity, Humans, Immune Sera chemistry, Immune Sera pharmacology, Japan epidemiology, Male, Middle Aged, Mumps epidemiology, Mumps virology, Mumps virus growth & development, Mumps virus isolation & purification, Neutralization Tests, Reassortant Viruses genetics, Vero Cells, Viral Fusion Proteins antagonists & inhibitors, Viral Fusion Proteins genetics, Antibodies, Viral blood, Mumps immunology, Mumps veterinary, Mumps virus genetics, Reassortant Viruses immunology, Viral Fusion Proteins immunology
- Abstract
Recently, a new paramyxovirus closely related to human mumps virus (MuV) was detected in bats. We generated recombinant MuVs carrying either or both of the fusion and hemagglutinin-neuraminidase bat virus glycoproteins. These viruses showed replication kinetics similar to human MuV in cultured cells and were neutralized efficiently by serum from healthy humans.
- Published
- 2016
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