1. Significant improvement in bone mineral density in pediatric celiac disease: even at six months with gluten-free diet.
- Author
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Gerenli N, Dursun F, Çeltik C, and Kırmızıbekmez H
- Subjects
- Celiac Disease metabolism, Child, Child, Preschool, Female, Humans, Male, Vitamin D analogs & derivatives, Vitamin D blood, Bone Density, Celiac Disease diet therapy, Diet, Gluten-Free
- Abstract
Objectives: Patients with celiac disease had significantly decreased bone mineral density even in patients with no gastrointestinal symptoms. Only few bone studies are available on pediatric patients with celiac disease., Methods: Forty-six patients underwent measurement of areal bone mineral density (aBMD) by dual-energy X-ray absorptiometry (DXA) before the initiation of gluten-free diet. Anthropometric, laboratory and DXA measurements at baseline and at sixth month of the treatment were compared., Results: The frequency of low aBMD Z-score (≤-1 SDS) in both or any site was found to be 78.2% in this study. Of 16 patients with an aBMD Z-score of <-2 SDS five gained more than 1 SDS, and one gained more than 2 SDS. Nine of 20 patients with an aBMD Z-score of <-1 SDS completely normalized., Conclusions: The results of the study showed that low BMD is common in children with celiac disease at the time of diagnosis and could improve in a short period of six months with a strict gluten-free diet and adequate supplementation of calcium and vitamin D., (© 2020 Walter de Gruyter GmbH, Berlin/Boston.)
- Published
- 2020
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