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1. [Role of biological defects in formation and development of bronchial asthma and potentialities of premorbid diagnosis].

Author

Fedoseev GB, Emel'ianov AV, Lototskiĭ AIu, Marchenko VN, Mineev VN, Nemtsov VI, Petrova MA, Sinitsina TM, Totolian AA, Trofimov VI, and Shaporova NL

Subjects
Disease Progression, Environmental Exposure adverse effects, Genetic Predisposition to Disease, Humans, Hypersensitivity, Immediate diagnosis, Hypersensitivity, Immediate genetics, Prognosis, Asthma diagnosis, Asthma genetics
Abstract

The paper considers bronchial asthma as a polygenic disease. It presents some data available in the literature on the role of genetic disorders in the development of atopic states and the authors' own findings of various biological defects detected in apparently healthy blood relatives of patients with bronchial asthma. It is concluded that premorbid diagnosis is of importance in high risk persons.

Published
2000

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