1. Evaluating antirheumatic treatments using synovial biopsy: a recommendation for standardisation to be used in clinical trials.
- Author
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van de Sande MG, Gerlag DM, Lodde BM, van Baarsen LG, Alivernini S, Codullo V, Felea I, Vieira-Sousa E, Fearon U, Reece R, Montecucco C, Veale DJ, Pitzalis C, Emery P, Klareskog L, McInnes IB, and Tak PP
- Subjects
- Arthritis, Rheumatoid drug therapy, Arthroscopy methods, Biopsy standards, Clinical Trials as Topic standards, Humans, Knee Joint pathology, Multicenter Studies as Topic standards, Treatment Outcome, Ultrasonography, Interventional methods, Antirheumatic Agents therapeutic use, Arthritis, Rheumatoid pathology, Biopsy methods, Synovial Membrane pathology, Synovitis pathology
- Abstract
Inflammation of synovium is one of the hallmarks of rheumatoid arthritis (RA). Analysis of synovial tissue has increased our understanding of RA pathogenesis, aided in identifying potential therapeutic targets and has been used in the response and mechanistic evaluation of antirheumatic treatments. In addition, studies are ongoing, aimed at the identification of diagnostic and prognostic biomarkers in the synovium. This paper outlines the currently used procedures for sampling and processing of synovial tissue, and presents a standardised recommendation to support multicentre translational research.
- Published
- 2011
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