1. Cell metabolism-based therapy for liver fibrosis, repair, and hepatocellular carcinoma.
- Author
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Gilgenkrantz H, Paradis V, and Lotersztajn S
- Subjects
- Humans, Cell- and Tissue-Based Therapy methods, Tumor Microenvironment, Animals, Carcinoma, Hepatocellular metabolism, Carcinoma, Hepatocellular pathology, Carcinoma, Hepatocellular therapy, Liver Neoplasms metabolism, Liver Neoplasms pathology, Liver Neoplasms therapy, Liver Cirrhosis metabolism, Liver Regeneration
- Abstract
Progression of chronic liver injury to fibrosis, abnormal liver regeneration, and HCC is driven by a dysregulated dialog between epithelial cells and their microenvironment, in particular immune, fibroblasts, and endothelial cells. There is currently no antifibrogenic therapy, and drug treatment of HCC is limited to tyrosine kinase inhibitors and immunotherapy targeting the tumor microenvironment. Metabolic reprogramming of epithelial and nonparenchymal cells is critical at each stage of disease progression, suggesting that targeting specific metabolic pathways could constitute an interesting therapeutic approach. In this review, we discuss how modulating intrinsic metabolism of key effector liver cells might disrupt the pathogenic sequence from chronic liver injury to fibrosis/cirrhosis, regeneration, and HCC., (Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.)
- Published
- 2025
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