1. A cucurbit[8]uril sponge.
- Author
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Ramalingam V, Kwee SK, Ryno LM, and Urbach AR
- Subjects
- Calorimetry, Dimerization, Molecular Conformation, Peptides chemical synthesis, Peptides chemistry, Bridged-Ring Compounds chemistry, Bridged-Ring Compounds isolation & purification, Imidazoles chemistry, Imidazoles isolation & purification
- Abstract
This paper describes a convenient approach to quantitative removal of the synthetic host cucurbit[8]uril (Q8) from aqueous mixtures using a sepharose resin coated in memantine groups to selectively sequester Q8 in the presence of competing hosts and guests. The "Q8 sponge" can separate Q8 from Q6 and reverse the Q8-mediated dimerization of peptides.
- Published
- 2012
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