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The question about correlation between organic and functional changes in persons, exposed to radiation is still insufficiently studied. Dynamics of morbidity for different forms and classes of non-tumour diseases periodisation, proposed by epidemiologists, suggests the identification of three main periods: «early» (the first 6 post-Chornobyl accident years); «distant» (12-21 years) and «late» (22-30 years). However, the correspondence this periodisation to the results of epidemiological data, without taking into account the clinical features of the diseases, may contribute to the impression, that in the first period after a radiation disaster functional disorders (or autonomic regulation disorders, etc.) prevail in all cases. Meanwhile, the data from ophthalmological and neurological studies, which we aim to demonstrate in this paper, rather indicate the presence of a significant morphological basis for the development of functional disorders in early period after a radiation disaster. The objective of this work is analyse modern experimental, epidemiological and clinical data on the correlation between organic and functional changes, characteristic of radiation cerebro-ophthalmological effects - radiation cataracts, age-related macular degeneration, cerebral small vessel disease, and neurocognitive deficits. Materials and methods. The criteria for inclusion in the analytical review were peer-reviewed publications in PubMed/MEDLINE, Scopus, Web of Science, and manually selected papers; the results of our own research were also used. An additional analysis of the results of examinations conducted in 1991-2004 was performed, which included a total of 11 123 persons irradiated as the result of catastrophy at the Chornobyl NPP. Results. In the first period of radiation cataract development, which is a specific consequence of radiation exposure, morphological changes (lens opacities) are observed, which lead to a decrease in visual function only later. Analysing the correlation between organic and functional changes in the development of diseases, for which ionising radiation exposure is a significant risk factor, we observe a similar picture. For example, CSVD associated with arterial hypertension may be a manifestation of accelerated aging associated with exposure to ionising radiation.Similarly, the initial signs of age-related macular degeneration in radiation-exposed individuals are usually manifested by changes in the morphology of the retina, choroid, and pigment epithelium in the macular area, while functional disorders in the form of decreased central vision and metamorphopsia, etc., occur later., (P. Fedirko, T. Babenko, K. Kuts, M. Pilmane, A. Yunga, N. Garkava.)

The analysis of long-term researches of the pathological changes arising in soft tissues at patients with a breast cancer as a result of radical surgical treatment and adjuvant radiotherapy is carried out in work. The article shows that the standard approach to postoperative radiation therapy, which is based only on the prevalence of the primary tumor process is not always justified. Very often it leads to excessive radiation load on the patient's body and the development of local acute and chronic radiation reactions of the skin, subcutaneous tissue and other soft tissues.In this regard, the question of differentiated purpose of radiotherapy acquires special value first of all at patients with small primary prevalence of tumor process. The paper presents the results of studies to study changes in the anterior chest wall in patients with breast cancer. In relation to the conduct of adjuvant radiotherapy more often need to use the concept of personalized radiation therapy. Radical operation, post-radiation early and late pathological changes in soft tissues, disturbance of microcirculation of lymph and blood, disturbance of innervation of vessels of an upper extremity, peripheral nerves in system of a cervical and plexus plexus, leads to intensive degen-erative and dystrophic changes in soft tissues of the upper. and causes morphological changes in them and further progression of reflex neurovascular and neurodystrophic disorders. Based on the data of adverse effects of radio-therapy on the skin and surrounding tissues, as well as to reduce excessive radiation exposure to the patient's body, a differentiated approach to the appointment of adjuvant radiation therapy., (D. A. Bazyka, O. O. Litvinenko, S. G. Bugaytsov, G. F. Shakhrai.)

Objective of research is to improve the electronic database of WBC measurements dated 1986 by inputting of newinformation from paper carriers, reconstruction of information gaps, verification and analysis of new entered data,revision of internal exposure doses that are based on results of WBC measurements dated 1986., Materials and Methods: In 2013-2015 during a revision of databases (DB) of WBC measurements results dated1986-2014, it was discovered a great amount of paper carriers with information about WBC measurements, includ-ing the ones dated 1986, that were not inputted to the electronic DB. The paper carriers were systematized andordered by the following indicators: place of residence of a person and place of WBC measurement, institution andoperator that made the measurement, measurement device and date of measurement. For a comfortable inputtingof the information to the electronic DB, it was additionally created a form which exists as an option in existing program complex Silbody (Version 19.0.9). In the revised DB of WBC measurements dated 1986 internal exposure dosesfrom radio-cesium of Chornobyl origin were computed based on an ecological and dosimetric model for radio-cesiummigration in environment and a model for radio-cesium metabolism in human body. In the work, mathematical andstatistical methods of research were used., Results: In 2019-2021 additionally 35,319 notes were inputted to the electronic DB of WBC measurement dated1986, and as a result its volume increased in 2.2 times. Mostly those are data on results concerning residents of Kyiv,Zhytomyr, Donetsk, Cherkasy, Odessa, Ivano-Frankivsk, and Rivne Oblasts. It was established the information onmeasurement devices and respectively on the minimal detected activity (MDA) for 27,119 notes (76.7 % of all newentered). Information is reconstructed about the body mass of all persons under investigation. Evaluation is madefor values of intake of incorporated radionuclides 137Cs and 134Cs for all new entered to DB. Quality of reconstructedinformation was analyzed. To group 1, «qualitative», it was classified 18,598 notes (53 % of all new entered), measurements in 1986 (including new entered). Dose not exceeding 1 mSv was obtained by 80 % of adults (older than20), as well as 73 % of persons younger than 20., Conclusion: To DB of WBC measurements, it was additionally inputted 35,319 notes on results of measurementsdated 1986. New entered information is verified and distributed by the quality groups. Individual exposure dosesevaluated based on those data can be used for further scientific research., (M. S. Kuriata, V. V. Vasylenko, O. M. Ivanova, M. S. Kramarenko, L. O. Lytvynets, V. V. Morozov, L. P. Misсhenko, Z. N. Boiko, V. B. Buderatska, M. I. Chepurny, A. G. Kukush.)

Background: Exposure to ionizing radiation could affect the brain and eyes leading to cognitive and vision impairment, behavior disorders and performance decrement during professional irradiation at medical radiology, includinginterventional radiological procedures, long-term space flights, and radiation accidents., Objective: The objective was to analyze the current experimental, epidemiological, and clinical data on the radiation cerebro-ophthalmic effects., Materials and Methods: In our analytical review peer-reviewed publications via the bibliographic and scientometric bases PubMed / MEDLINE, Scopus, Web of Science, and selected papers from the library catalog of NRCRM - theleading institution in the field of studying the medical effects of ionizing radiation - were used., Results: The probable radiation-induced cerebro-ophthalmic effects in human adults comprise radiation cataracts,radiation glaucoma, radiation-induced optic neuropathy, retinopathies, angiopathies as well as specific neurocognitive deficit in the various neuropsychiatric pathology including cerebrovascular pathology and neurodegenerativediseases. Specific attention is paid to the likely stochastic nature of many of those effects. Those prenatally and inchildhood exposed are a particular target group with a higher risk for possible radiation effects and neurodegenerative diseases., Conclusions: The experimental, clinical, epidemiological, anatomical and pathophysiological rationale for visualsystem and central nervous system (CNS) radiosensitivity is given. The necessity for further international studieswith adequate dosimetric support and the follow-up medical and biophysical monitoring of high radiation riskcohorts is justified. The first part of the study currently being published presents the results of the study of theeffects of irradiation in the participants of emergency works at the Chornobyl Nuclear Power Plant (ChNPP)., (K.N. Loganovsky, P.A. Fedirko, K.V. Kuts, D. Marazziti, K.Yu. Antypchuk, I.V. Perchuk, T.F. Babenko, T.K. Loganovska, O.O. Kolosynska, G.Yu. Kreinis, M.V. Gresko, S.V. Masiuk, L.L. Zdorenko, N.A. Zdanevich, N.A. Garkava, R.Yu. Dorichevska, Z.L. Vasilenko, V.I. Kravchenko, N.V. Drosdova, Yu.V. Yefimova.)

A clinical case of cutaneous T-cell lymphoma is presented in this paper - Mycosis fungoides, a tumorous stage that developed in a patient who suffered as a result of the Chornobyl accident. The most likely development of this di- sease is due to the influence of the radiation factor, which led to the affection of lymphoid cells. This disease has characteristic staging with a typical morphological pattern only in later stages, therefore, the diagnosis usually occurs in evident clinical and histological changes of the mycotic and tumorous stages, when treatment is ineffec- tive. The features of the disease and treatment are described., (L. V. Hrechanska, L. D. Kaliuzhna, P.V. Fedorych, A.V. Petrenko.)

In this paper, a clinical case of combination of chronic myeloid leukemia and T-lymphoblastic lymphoma is present-ed, which is currently a rather rare finding for a clinician. The diagnosis of T-lymphoblastic lymphoma is establishedafter 2 years from the verification of chronic myeloid leukemia. The course of diseases and approaches to treatmentare described.The pathogenetic relationship between myeloid and lymphoid diseases remains unclear and is likely to be the resultof several factors - radiation, chemical and, consequently, genetic disorders., (I. S. Dyagil, V. V. Sholoyko, Yu. O. Silayev, Z. V. Martina, I. V. Dmytrenko, A. O. Tovstogan, V. G. Fedorenko, T. Yu. Shlyakhtychenko, Zh. M. Minchenko.)

Objective: revision, analysis, and significant improvement of quality of the database of WBC measurements made in1986-2014 at radioactively contaminated territories of Ukraine by the use of renewal of informational gaps andimprovement of the model for assessment of internal exposure doses., Materials and Methods: Inthe periodfrom 1986 to 2014 experts of the Whole Body Counters Laboratory of NRCRMaccumulated about 1.5 million results of WBC measurementsof radio-cesium incorporated in the body of personsresiding at the territories which are radioactively contaminated due to Chornobyl accident. Most of measurements(~64 %) were made during the first 15 years after the accident. The most of measurements were made in Kyiv (~23 %),Zhytomyr (~36 %), Rivne (~20 %) and Chernihiv (~5 %) Oblasts. Works on revision of database of WBC measurementsincluded: transformation of data saved in paper format into electronic form, checking for correctness and correspon-dence of information, renewal of lacking information at the fields of database, improvement of the model for eval-uation of internal exposure doses by the data of WBC measurements. In the model for evaluation of revised doses,it is assumed uniform content of radio-cesium during a year. Reference values are used of metabolism parametersand anthropometric human parameters recommended in publications of ICRP., Results: Revised doses have been reconstructed for 1,386,585 records of data base of WBC measurements that fitspecially elaborated criterions for estimation of quality of results. Among them 604,215 records are WBC measure-ments of children and adolescents younger than 18, and 782,370 records correspond to adult inhabitants of Ukraine,most of which reside in Zhytomyr, Kyiv, Rivne and Chenihiv Oblasts., Conclusions: Obtained results serve as a ground for further works on improvement of models for evaluation of pass-port doses and individualized exposure doses of subjects registered in Ukrainian State Register - of persons thataffected due to Chornobyl accident. Evaluated doses can be used for epidemiological, clinical and other research., (V. V. Vasylenko, S. V. Masiuk, О. М. Ivanova, V. O. Pikta, Z. N. Boiko, М. І. Chepurny, V. B. Buderatska, G. M. Zadorozhna, L. O. Lytvynets, M. S. Kramarenko, G. V. Fedosenko, A. G. Kukush, M. S. Kuriata, N. S. Zhadan, T. F. Babenko.)

Nuclear installations may contain a large inventory of radioactive material and an emergency caused by an accident, natural disaster, or malevolent act may cause uncontrolled releases of radionuclides to the environment. The paper presents a brief overview of individual radiological monitoring in case of major releases of radionuclides to the environment and introduces the new Report 92 of the International Commission on Radiation Units and Measurements (ICRU) on Radiation Monitoring for Protection of the Public after Major Releases of Radionuclides to the Environment. The Report was prepared taking into account the results of the research «Development of the program for radiation and hygienic monitoring for the radiological protection of human under radiation accidents and acts of nuclear terrorism» which was carried out in the internal dosimetry laboratory of the NRCRM of NAMS of Ukraine in 2016-2018. The Report Committee was headed by the scientific supervisor of the research, the Committee consisted of leading experts from UK, Italy, China, Germany, Russia, Slovenia, United States, Ukraine, Japan, and experts from the International Atomic Energy Agency. The preparation of the Report was supported by the US Environmental Protection Agency, US Nuclear Regulatory Commission, US Department of Energy, National Academy of Medical Sciences of Ukraine, and Radiation Protection Institute of the ATS of Ukraine., (V. Berkovski, G. Ratia, Yu. Bonchuk.)

Study Objective: To elaborate an ecological dosimetric model of reconstruction individualized exposure doses of subjects from the State Register of Ukraine (SRU) - of persons, affected due to Chornobyl accident and reside at the radioactive contaminated territory of Korosten raion of Zhytomyr Oblast, and to calculate exposure doses for those persons., Materials and Methods: In the paper, an ecological dosimetric model is presented which is elaborated in order to individualize exposure doses of people who reside in Korosten raion of Zhytomyr Oblast and are registered in SRU. The model is based on the results of radio ecological and dosimetric monitoring held in the period of 1986-2013 at the territory of northern oblasts of Ukraine. Annual dose over each post accidental year consists of the two compo nents: (a) annual effective dose of external gamma exposure (due to radioactive fallout on the ground), and (b) internal exposure of the whole body (due to consumption of meal contaminated by radioactive isotopes). For 1986, the dose of internal exposure is evaluated out of all main radionuclides of radioactive accidental fallout, and after 1987 only for radioisotopes of caesium (134Cs and 137Cs). The parameterization of the model is based on the pre vious experience in working out a complex of ecological dosimetric models for estimation of referent exposure doses of Ukrainian population., Results and Conclusions: Individualized doses of external and internal exposure (annual and accumulated) are estimated for the population of various age groups that resides in the settlements of Korosten raion (totally about 100 settlements). Separately the doses are presented for rural settlements of the raion and for the city of Korosten for each year of the post accidental period of 1986-2016. Estimates of doses are given that were accumulated: (a) during 15 years just after the accident, (b) for the period of 2000-2016, and (c) for 30 year period after the acci dent. Mean dose accumulated for 30 years after the Chornobyl accident by residents of rural settlements of Korosten raion is estimated as 19.8 mSv, and for inhabitants of the Korosten city as 20.9 mSv. On condition of permanent res idence in the raion, residents of about 66 % settlements of Korosten raion accumulated the doses in the interval 5 20 mSv during 30 years after the accident. For the residents of about 25 % settlements the accumulated dose is in the interval 20-50 mSv, and for 7 % of settlements it exceeds 50 mSv., (О. М. Ivanova, S. V. Masiuk, Z. N. Boiko, М. І. Chepurny, V. B. Gerasymenko, G. V. Fedosenko, V. V. Vasylenko, L. O. Lytvynets, V. O. Pikta, L. М. Kovgan, N. S. Zhadan, S. О. Tereshchenko, І. G. Kravchenko, G. І. Коrtushin, О. D. Marcenjuk, A. G. Kukush.)

Numerous scientific studies have been carried out since the ChNPP accident indicating that the last one has caused a severe psychosocial stress in survivors. Population of radioactively contaminated territories, people migrated from the areas of strict radiation control, and accident consequences clean up participants in 1986 1987 were covered by the conducted research projects. Nature of the stress herewith is polygenic and includes factors directly related to the Chernobyl catastrophe, and factors being a result of social and economic circumstances. This report is devot ed to the results of research on psychosocial state of population evacuated from the 30 km zone of the ChNPP., Objective: Study and evaluation of psychosocial state of population evacuated from the 30 km ChNPP zone at the age of 18 years and older; identification of potential psychosocial risk factors for the health loss., Materials and Methods: The sampling epidemiological study of psychosocial state of population aged 18-50 years evacuated from the 30 km zone of ChNPP was conducted at the NRCRM Radiation Registry Outpatient Clinic and Radiation Psychoneurology Department. The study subjects (n=258) were mostly (98%) females. Study was con ducted from October 2013 till May 2015. All the sample members were registered since 1992 in the system of life long health monitoring, i.e. the NRCRM Clinical and Epidemiological Registry. Study subjects were interviewed through the method using an original «Questioning Inventory». Mathematical processing of study results was held using the Epi Info 7 software package., Results: According to the study results, a nuclear accident at the Chornobyl NPP has become a powerful psychoso cial stress for evacuated people. Psychosocial state of the evacuees, formed during the post accident period, with full reason can be defined as a state of stable, chronic psychosocial stress. Nature of factors that caused the stress development is polygenic. Block of stressors directly related to the accident was determined, namely there were «change of radiation and ecological situation», «ionizing irradiation», «evacuation», and «radical breaking of dynamic stereotype of behavior and life». In parallel there was selected a block of stress factors generated by that background, i.e. psychological, social, economic, and cultural, on which a nuclear disaster was imposed upon. The effects of stress have manifested as a persistent syndrome of «anxiety» for the personal health and health of fami ly members, primarily the children, and as a stable state of «dissatisfaction» with fullness and quality of life., Conclusions: The nuclear accident at the ChNPP has been the cause of a strong psychosocial stress in adult evacu ated population, especially in women. Further in a remote period the stress was transformed into a stable, chronic form. Nature of stress is polygenic and includes stressors directly related to the accident, and stressors that are not directly related to the accident consequences, but are due to the level of social, economic, medical, and informa tional protection of survivors. Data presented in the paper are rather enough important for the formation of strate gies and measures for social and psychological protection of population in an event of nuclear accidents and incidents., (V. O. Buzunov, K. M. Loganovsky, L. I. Krasnikova, M. O. Bomko, Yu. M. Belyayev, Zh. S. Yaroshenko, T. E. Domashevska.)

The objective of this paper is to analyze the data from scientific literature and available recommendations for health professionals on healthcare providing to pediatric population in the events associated with risk of radiation exposure. Over the past sixty years there were several large scale radiological events with a large number of chil dren affected, namely the atomic bombing of Hiroshima and Nagasaki, accident at the Chornobyl nuclear power plant, contact to 137Cs radiation source unutilized at the hospital shutdown in Brazil etc. Further research has crys tallized injuries and health disorders in the survived children in all cases being much more significant vs. other pop ulations. Analysis of circumstances and features of a number of emergency situations or incidents in the nuclear industry for several decades has shown a high probability of radioactive materials release into the environment. The danger of terrorism with the use of ionizing radiation sources resulting in a considered inevitable hazard to the chil dren is estimated as serious in recent years and deserves an especial mention here., (D. E. Afanasyev, O. V. Kaminskyi, O. V. Kopylova, I. G. Chikalova, I. M. Muraveva, K. O. Vakoluk, O. V. Pronin, O. O. Samoylov, T. O. Belingio, O. V. Tepla, L. V. Rozhkivska, I. V. Ylyanchenko, K. V. Gryschenko, L. O. Tsvet, N. S. Dombrovska.)

Recently, an increasing interest has been directed towards the investigation of brain effects of ionizing radiation (IR), as it is now evident that, depending on the doses, the damages character and severity, as well as clinical man ifestations are different. They are generally considered to be the result of a blending of atherosclerotic, cardiovas cular, cerebrovascular and neurodegenerative processes. Further, an ongoing debate has been opened on the pos sible brain abnormalities following medical radiation from X ray in interventional radiology and nuclear medicine procedures that would involve both patients and medical workers. The aim of the present paper is to summarize literature data on brain effects of IR exposure, with a special focus on those gathered by some of the authors after the Chornobyl nuclear plant disaster, and how they can be related to the pathophysiology of different neuropsy chiatric disorders., (D. Marazziti, A. Piccinni, F. Mucci, S. Baroni, K. Loganovsky, T. Loganovskaja.)

Objective: to assess and estimate the peculiarities of genital system morbidity in female participants of the ChNPP accident clean up works in 1986-1987 depending on age at exposure to ionizing radiation and time since exposure., Materials and Methods: Data on the Chernobyl disaster survivors received from the State Registry of Ukraine are out line in the paper. Review of the level and pattern of genital system morbidity was carried out for the 17,237 female participants of the ChNPP accident clean up works in 1986-1987 depending on time under risk upon radiation expo sure and reproductive age at exposure. Survey period lasted since 1988 till 2012. Assessment of morbidity level, con fidential intervals, and statistical significance was carried out using the trial version of ОpenEpiversion 2.3.1. soft ware. Statistical significance was also rated using the z score and t criterion., Results: The results of this cohort epidemiological study showed that there are some peculiarities of natural course of the female genital system disease depending on reproductive age at exposure and time under risk upon radiation impact. Comparative statistical review of the level and pattern of genital system morbidity at different times within a survey period., Conclusion: Exposure to ionizing radiation in the childbearing age (18-45 years old) can be a risk factor of elevated incidence of uterine leiomyoma, benign mammary dysplasia (i.e. benign breast disease), and salpingo oophoritis. It is far to assume that uterine and mammary tissues are more sensitive to impact of ionizing radiation in females of the childbearing age vs. in persons exposed in pre menopause or menopause., (I. O. Mayevska, V. O. Buzunov.)

Objective. The purpose of this study was to determine the key factors of social well-being of the population in surveillance zone Rivne NPP. Materials and methods. Sociological, hygienic and mathematical methods i.e. comparison of generalized performance characteristics such as relative and average values, expression of interactions between factors using a pairwise correlation (r) were used in the paper. A questionnaire was developed for the public opinion polls with independent blocks of issues: the study of living environment/conditions through the assay of adequacy of ten major areas of life, assessment of satisfaction with the quality of life in household sphere and components and cost items of family budget, satisfaction level of medical care, "Integral Index of Social Well-being" Test (IISW). The sample was representative by age and gender for population of the surveillance zone of Rivne NPP (n=220, 6.7% sampling error). Results. According to opinion polls there is a negative impact on social well-being of low sufficiency in issues of socio-political life, social security and social relations. More than a half of population feels no any socio-economic compensation for the risk of Rivne NPP function in their daily lives. The overall satisfaction index in recreational and cultural sphere is close to the national average value, which may indirectly indicate to a positive impact of subventions to the social infrastructure of surveillance zone. However, satisfaction of population in the required medical care is extremely low, as is the case throughout Ukraine, due to several factors, such as lack of specialists, poor providing with essential medicines, and high cost of medicines. Conclusions. The list of benefits and compensations associated with living near the functioning NPP needs improvement and coordination with opinion of local communities. Their implementation at that needs a permanent information support. Some links are established between areas that are important in shaping of social feelings and assessment of environmental situation, perception of radiation situation, possibility of socio-political, man-made and natural emergencies. The more confident respondents in welfare of ecological state of residence, the higher level is in their social comfort., (V. A. Prilipko, Iu. Iu. Ozerova, M. M. Morozova, K. K. Shevchenko.)

This paper discusses the approaches to regulation of the content of radionuclides in commodities and compares the international and Ukrainian standards, which establish permissible levels of the content of radionuclides in food-stuffs produced in the Chornobyl-affected areas. The paper gives the actual monitoring data and discusses the main causes of differences between Ukrainian, European and international standards. The need for improvement of current approaches to the regulation of the content of radionuclides in commodities is highlighted., (V. B. Berkovskyy, G. G. Ratia, S. V. Masiuk, Yu. V. Bonchuk, V. B. Gerasimenko, P. B. Aryasov, T. V. Treskunova, N. S. Zhadan, O. M. Ivanova, Z. N. Boyko.)

The objective of this at issue paper is the analysis of published data in correlation with the results of own research on the potential role of ionizing radiation in the genesis of depressive disorders. Depression is one of the most significant and long-term effect of the atomic bombings, nuclear testing and radiation emergences. The participants of the accident at the Chornobyl nuclear power plant increased prevalence of depression (18.0% and 13.1% in controls) and suicide rates. Depression is mainly observed in the structure of an organic mental disorder against cerebrovascular disease. The clinical pattern is dominated by asthenoadynamic and asthenoapathetic depression. Depressive disorders in radiation emergencies are multifactorial, that is the result of exposure to the complex psychogenic and radiological accident's factors, impact of traditional risk factors, somatic and neurological diseases, genetic predisposition, predisposition, etc. At the same time, exposure to ionizing radiation is a factor in the genesis of depression. This impact can be direct (to the Central Nervous System), and indirectly through the somatic and neurological abnormalities (multiorgan dysfunction) as well as by a variety of pathogenic mechanisms of ionizing radiation on the brain that have been discovered recently. It is strongly necessary analytical clinical and epidemiological studies with verification of depression and evidence-based establishment of the role of radiation and non-radiation risk factors., (Loganovskyj K. N., Vasylenko Z. L., 2013.)

Unlabelled: The objective of the paper was to analyze the individual risk factors for coronary heart disease in a group of clean-up workers, who had developed a myocardial infarction (MI) after the Chornobyl NPP accident., Methods: Data of 525 clean-up workers with a first MI event were analyzed among all uniquely identifiable clean-up workers registered in the Clinical and Epidemiological Registry (CER) of NRCRM. The comparison was carried out with a control group of 110 residents of Kyiv, who had MI within 2004-2009., Results: It was found that the proportion of patients who had MI under 45 years was increased in the first 10 years after the Chornobyl accident, being first of all due to the age structure of the clean-up worker's cohort as a whole. The distribution of patients by age in the following years was close to that in the other MI cohorts described in the literature. The external radiation dose of men who developed MI in the first 5 years after the Chornobyl NPP accident was 39.58 ± 6.72 cSv (median 25 cSv) which exceeded the dose of men who had got the MI later (23.78 ± 2.43 cSv, median 12 cSv; p=0.009)., Conclusions: The quantity of the male patients with minimum number of risk factors was gradually reducing along with time since the Chornobyl accident and accordingly the proportion of patients with three or more risk factors was increased (p=0.001). Incidence of obesity and hypercholesterolemia among male clean-up workers was higher than in the control group of male inhabitants of Kyiv., (Chumak A. A., Pleskach G. V., 2013.)