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2. Commemorating the 1913 Michaelis–Menten paper Die Kinetik der Invertinwirkung: three perspectives
3. Transparent publishing - reinventing the paper
4. Native architecture of the centriole proximal region reveals features underlying its 9-fold radial symmetry: SPE-1-4 The 2013 Paper of the Year
5. Design, execution, and analysis of pooled in vitro CRISPR/Cas9 screens
6. The interaction network of rhodopsin involving the heterotrimeric G-protein transducin and the monomeric GTPase Rac1 is determined by distinct binding processes
7. Understanding allosteric and cooperative interactions in enzymes
8. Michaelis–Menten at 100 and allosterism at 50: driving molecular motors in a hailstorm with noisy ATPase engines and allosteric transmission
9. Enzyme catalysis and allostery: a century of advances in molecular understanding
10. Introduction: Focus on mitochondria
11. From steady-state to synchronized yeast glycolytic oscillations II: model validation
12. Structural basis for olivetolic acid formation by a polyketide cyclase from Cannabis sativa
13. Understanding the cancer cell phenotype beyond the limitations of current omics analyses
14. Sequencing, biochemical characterization, crystal structure and molecular dynamics of cellobiohydrolase Cel7A from Geotrichum candidum 3C
15. Crystal structure of LptH, the periplasmic component of the lipopolysaccharide transport machinery from Pseudomonas aeruginosa
16. Insights into the slow-onset tight-binding inhibition of Escherichia coli dihydrofolate reductase: detailed mechanistic characterization of pyrrolo [3,2-f] quinazoline-1,3-diamine and its derivatives as novel tight-binding inhibitors
17. ClpL is a chaperone without auxiliary factors
18. Feedforward regulation of mRNA stability by prolonged extracellular signal-regulated kinase activity
19. The FEBS Journal in 2015: onwards and upwards
20. Crystal structures of apparent saccharide sensors from histidine kinase receptors prevalent in a human gut symbiont
21. A brief history of macromolecular crystallography, illustrated by a family tree and its Nobel fruits
22. From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug design
23. Structural and functional diversity of metalloproteinases encoded by the Bacteroides fragilis pathogenicity island
24. Allosteric regulation and substrate activation in cytosolic nucleotidase II from Legionella pneumophila
25. Challenges for an enzymatic reaction kinetics database
26. Variations on the theme: allosteric control in hemoglobin
27. New types of experimental data shape the use of enzyme kinetics for dynamic network modeling
28. Spider toxins comprising disulfide-rich and linear amphipathic domains: a new class of molecules identified in the lynx spider Oxyopes takobius
29. Protein crystallography for aspiring crystallographers or how to avoid pitfalls and traps in macromolecular structure determination
30. The transporter–opsin–G protein-coupled receptor (TOG) superfamily
31. Comparison of complexes formed by a crustacean and a vertebrate trypsin with bovine pancreatic trypsin inhibitor – the key to achieving extreme stability?
32. Conserved systems and functional genomic assessment of nociception
33. Neurodegeneration – from multiple sclerosis to Alzheimerʼs disease
34. A steady-state theory for processive cellulases
35. PARP inhibitors: polypharmacology versus selective inhibition
36. In vitro reconstitution of complexes between pro-matrix metalloproteinase-9 and the proteoglycans serglycin and versican
37. Mapping the interactions of selected antibiotics and their Cu2+ complexes with the antigenomic delta ribozyme
38. Autoprocessing mechanism of severe acute respiratory syndrome coronavirus 3C-like protease (SARS-CoV 3CLpro) from its polyproteins
39. Influence of cyanide on diauxic oscillations in yeast
40. Does human leukocyte elastase degrade intact skin elastin?
41. From steady-state to synchronized yeast glycolytic oscillations I: model construction
42. Quinolinic acid, the inescapable neurotoxin
43. The catalytic core of an archaeal 2-oxoacid dehydrogenase multienzyme complex is a 42-mer protein assembly
44. Computational approaches to disease-gene prediction: rationale, classification and successes
45. Visualization of Cu2+ uptake and release in plant cells by fluorescence lifetime imaging microscopy
46. Dual localization of glutathione S-transferase in the cytosol and mitochondria: implications in oxidative stress, toxicity and disease
47. Substrate-induced conformational changes in Plasmodium falciparum guanosine monophosphate synthetase
48. A short-chain dehydrogenase involved in terpene metabolism from Zingiber zerumbet
49. Concepts and tools to exploit the potential of bacterial inclusion bodies in protein science and biotechnology
50. Enzyme kinetics informatics: from instrument to browser
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