63 results on '"Kay, Lewis E."'
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2. Opening of a cryptic pocket in β-lactamase increases penicillinase activity
3. The A39G FF domain folds on a volcano-shaped free energy surface via separate pathways
4. Dissecting the role of interprotomer cooperativity in the activation of oligomeric high-temperature requirement A2 protein
5. Competing stress-dependent oligomerization pathways regulate self-assembly of the periplasmic protease-chaperone DegP
6. Interaction hot spots for phase separation revealed by NMR studies of a CAPRIN1 condensed phase
7. Oligomeric assembly regulating mitochondrial HtrA2 function as examined by methyl-TROSY NMR
8. An intrinsically disordered motif regulates the interaction between the p47 adaptor and the p97 AAA+ ATPase
9. A methyl-TROSY approach for NMR studies of high-molecular-weight DNA with application to the nucleosome core particle
10. An allosteric switch regulates Mycobacterium tuberculosis ClpP1P2 protease function as established by cryo-EM and methyl-TROSY NMR
11. Exploring long-range cooperativity in the 20S proteasome core particle from Thermoplasma acidophilum using methyl-TROSY–based NMR
12. Stabilization of amyloidogenic immunoglobulin light chains by small molecules
13. Role of domain interactions in the aggregation of full-length immunoglobulin light chains
14. Cooperative subunit dynamics modulate p97 function
15. Reversible inhibition of the ClpP protease via an N-terminal conformational switch
16. Cotranslocational processing of the protein substrate calmodulin by an AAA+ unfoldase occurs via unfolding and refolding intermediates
17. Effects of maturation on the conformational free-energy landscape of SOD1
18. New Tools Provide New Insights in NMR Studies of Protein Dynamics
19. Quantitative NMR Spectroscopy of Supramolecular Complexes: Dynamic Side Pores in ClpP Are Important for Product Release
20. Variable Control of Ets-1 DNA Binding by Multiple Phosphates in an Unstructured Region
21. Solution NMR-Derived Global Fold of a Monomeric 82-kDa Enzyme
22. Sparsely Populated Folding Intermediates of the Fyn SH3 Domain: Matching Native-Centric Essential Dynamics and Experiment
23. The Integral Membrane Enzyme PagP Alternates between Two Dynamically Distinct States
24. Dramatic Acceleration of Protein Folding by Stabilization of a Nonnative Backbone Conformation
25. Probing the cooperativity of Thermoplasma acidophilum proteasome core particle gating by NMR spectroscopy
26. Structural and hydrodynamic properties of an intrinsically disordered region of a germ cell-specific protein on phase separation
27. Exploiting conformational plasticity in the AAA+ protein VCP/p97 to modify function
28. The Energetic Cost of Domain Reorientation in Maltose-Binding Protein as Studied by NMR and Fluorescence Spectroscopy
29. Site-Specific Contributions to the pH Dependence of Protein Stability
30. Structure of a Regulatory Complex Involving the Abl SH3 Domain, the Crk SH2 Domain, and a Crk-Derived Phosphopeptide
31. Solution Structure and Dynamics of the Outer Membrane Enzyme PagP by NMR
32. High-Affinity Binding of the Drosophila Numb Phosphotyrosine-Binding Domain to Peptides Containing a Gly-Pro-(p)Tyr Motif
33. α Helix-RNA Major Groove Recognition in an HIV-1 Rev Peptide-RRE RNA Complex
34. Probing the free energy landscapes of ALS disease mutants of SOD1 by NMR spectroscopy
35. Unfolding the mechanism of the AAA+ unfoldase VAT by a combined cryo-EM, solution NMR study
36. Hsp70 biases the folding pathways of client proteins
37. ClpB N-terminal domain plays a regulatory role in protein disaggregation
38. Mapping the conformation of a client protein through the Hsp70 functional cycle
39. Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site
40. Measuring hydrogen exchange rates in invisible protein excited states
41. Measurement of histidine pKa values and tautomer populations in invisible protein states
42. Understanding the mechanism of proteasome 20S core particle gating
43. Tracing an allosteric pathway regulating the activity of the HsIV protease
44. NMR paves the way for atomic level descriptions of sparsely populated, transiently formed biomolecular conformers
45. Defining a length scale for millisecond-timescale protein conformational exchange
46. Unraveling the Mechanism of Protein Disaggregation Through a ClpB-DnaK Interaction
47. Proteasome allostery as a population shift between interchanging conformers
48. Folding of the four-helix bundle FF domain from a compact on-pathway intermediate state is governed predominantly by water motion
49. Transiently populated intermediate functions as a branching point of the FF domain folding pathway
50. Structure of an Intermediate State in Protein Folding and Aggregation
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