78 results on '"Beutler, Bruce"'
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2. Sulfatides are endogenous ligands for the TLR4–MD-2 complex
3. Thousands of induced germline mutations affecting immune cells identified by automated meiotic mapping coupled with machine learning
4. Forward genetic analysis using OCT screening identifies Sfxn3 mutations leading to progressive outer retinal degeneration in mice
5. Tissue-specific disruption of Kbtbd2 uncovers adipocyte-intrinsic and -extrinsic features of the teeny lipodystrophy syndrome
6. Genetic and structural studies of RABL3 reveal an essential role in lymphoid development and function
7. Essential requirement for nicastrin in marginal zone and B-1 B cell development
8. YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity
9. Enhanced susceptibility to chemically induced colitis caused by excessive endosomal TLR signaling in LRBA-deficient mice
10. Excessive endosomal TLR signaling causes inflammatory disease in mice with defective SMCR8-WDR41-C9ORF72 complex function
11. Adjuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti–PD-L1 to eliminate melanoma in mice
12. The Extracellular Matrix Gene Frem1 Is Essential for the Normal Adhesion of the Embryonic Epidermis
13. Toll-Like Receptors 9 and 3 As Essential Components of Innate Immune Defense against Mouse Cytomegalovirus Infection
14. Skin-specific regulation of SREBP processing and lipid biosynthesis by glycerol kinase 5
15. Creatine maintains intestinal homeostasis and protects against colitis
16. IgD class switching is initiated by microbiota and limited to mucosa-associated lymphoid tissue in mice
17. Assay of Locus-Specific Genetic Load Implicates Rare Toll-like Receptor 4 Mutations in Meningococcal Susceptibility
18. Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
19. Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice
20. Mutation of Fnip1 is associated with B-cell deficiency, cardiomyopathy, and elevated AMPK activity
21. TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS
22. Mutation of the ER retention receptor KDELR1 leads to cell-intrinsic lymphopenia and a failure to control chronic viral infection
23. Comparison of predicted and actual consequences of missense mutations
24. Real-time resolution of point mutations that cause phenovariance in mice
25. MAVS, cGAS, and endogenous retroviruses in T-independent B cell responses
26. Toll-Like Receptor 4 Polymorphisms Are Associated with Resistance to Legionnaires' Disease
27. Endosomal TLR Signaling Is Required for Anti-Nucleic Acid and Rheumatoid Factor Autoantibodies in Lupus
28. B-1a transitional cells are phenotypically distinct and are lacking in mice deficient in IkBNS
29. Mutation of mouse Samd4 causes leanness, myopathy, uncoupled mitochondrial respiration, and dysregulated mTORC1 signaling
30. Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus
31. Disruption of copper homeostasis due to a mutation of Atp7a delays the onset of prion disease
32. QnAs with Bruce Beutler
33. A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity
34. Yip1 domain family, member 6 (Yipf6) mutation induces spontaneous intestinal inflammation in mice
35. Tuning of Natural Killer Cell Reactivity by NKp46 and Helios Calibrates T Cell Responses
36. Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet
37. Hypermorphic mutation of the voltage-gated sodium channel encoding gene Scn10a causes a dramatic stimulus-dependent neurobehavioral phenotype
38. ATP-sensitive potassium channel (K ATP )–dependent regulation of cardiotropic viral infections
39. Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses
40. X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C
41. TNF-α from inflammatory dendritic cells (DCs) regulates lung IL-17A/IL-5 levels and neutrophilia versus eosinophilia during persistent fungal infection
42. Critical coordination of innate immune defense against Toxoplasma gondii by dendritic cells responding via their Toll-like receptors
43. JNK1 controls mast cell degranulation and IL-1β production in inflammatory arthritis
44. Participation of the p38 pathway in Drosophila host defense against pathogenic bacteria and fungi
45. Plant and Animal Sensors of Conserved Microbial Signatures
46. Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells
47. MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands
48. IRAK1BP1 inhibits inflammation by promoting nuclear translocation of NF-κB p50
49. Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells
50. A Mutation of Ikbkg Causes Immune Deficiency without Impairing Degradation of lkBα
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