Search

Your search keyword '"Yoko Nakajima"' showing total 1 results
Start Over Author "Yoko Nakajima" Database Gale General OneFile
1 results on '"Yoko Nakajima"'

1. Acridine adduct of [60]fullerene with enhanced DNA-cleaving activity

Author

Yamakoshi, Yoko Nakajima, Yagami, Takeshi, Sueyoshi, Shoko, and Miyata, Naoki

Subjects
Carbon allotropes -- Research, Organic compounds -- Synthesis, Biological sciences, Chemistry
Abstract

[60]Fullerene (C60) has been chemically and structurally modified to induce its DNA-cleaving activities. The approach involved aziridino addition of 9-(4-methylphenyl)acridine, a benzyl azide derivative of acridine, into C60 in the presence of o-dichlorobenzene at 130 degrees Centigrade. The resulting bromomethyl derivative was converted to 9-[4-(azidomethyl)phenyl acridine. Spectroscopy of the product showed that it was a monoadduct, with a molecular formula of C80H14N2.

Published
1996

Catalog

Books, media, physical & digital resources
See catalog results