1. Conventional kinesin holoenzymes are composed of heavy and light chain homodimers
- Author
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DeBoer, Scott R., YiMei You, Szodorai, Anita, Kaminska, Agnieszka, Pigino, Gustavo, Nwabuisi, Evelyn, Bin Wang, Estrada-Hernandez, Tatiana, Kins, Stefan, Brady, Scott T., and Morfini, Gerardo
- Subjects
Antibodies -- Structure ,Viral antibodies -- Structure ,Immune response -- Analysis ,Kinesin -- Chemical properties ,Kinesin -- Structure ,Neurons -- Structure ,Biological sciences ,Chemistry - Abstract
The immunoprecipitation experiments via well-validated, highly specific antibodies that selectively recognize each kinesin-1 and kinesin light chain (KLC) subunit were performed to gain insight on the biochemical heterogeneity of conventional kinesin. The results for the subunit-dependent heterogeneity of conventional kinesin and their homodimerization properties provide a molecular basis for the transport regulation of selected membrane-bounded organelles (MBOs) in neurons.
- Published
- 2008