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1. Mechanism of the cardioprotective effect of transforming growth factor beta(sub 1) in feline myocardial ischemia and reperfusion

Author

Lefer,Allan M., Xin-Liang Ma, Weyrich, Andrew S., and Scalia, Rosario

Subjects
Transforming growth factors -- Physiological aspects, Coronary heart disease -- Research, Reperfusion injury -- Research, Science and technology
Abstract

The effects of transforming growth factor beta1 (TGF-beta1) in a feline model of myocardial ischemia and reperfusion were studied. It was demonstrated that a cardioprotective effect of TGF-beta1 occurs on reperfusion injury following myocardial ischemia. The mechanism of this cytoprotective effect appears to be the endothelial preservation by TGF-beta1 inhibiting circulating neutrophils from adhering to the endothelium.

Published
1993

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