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Your search keyword '"Wilton, Lynda V."' showing total 9 results
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9 results on '"Wilton, Lynda V."'

1. The safety of quetiapine: results of a post-marketing surveillance study on 1728 patients in England

Author

Twaites, Beverley R., Wilton, Lynda V., and Shakir, Saad A.W.

Subjects
Drug therapy, Research, Methods, Quetiapine -- Research, Extrapyramidal disorders -- Drug therapy -- Research, Drug monitoring -- Methods -- Research, Drug utilization -- Methods -- Research
Abstract

The safety of the atypical antipsychotic quetiapine as used in general practice in England was examined by prescription-event monitoring (PEM). Patients were identified from dispensed National Health Service (NHS) prescriptions [...]

Published
2007

3. Pharmacovigilance study of alendronate in England

Author

Biswas, Pipasha N., Wilton, Lynda V., and Shakir, Saad A. W.

Subjects
Postmenopausal women -- Health aspects, Osteoporosis -- Drug therapy, Alendronate -- Usage, Alendronate -- Complications and side effects, Health
Abstract

Byline: Pipasha N. Biswas (1), Lynda V. Wilton (1,2), Saad A. W. Shakir (1,2) Keywords: Alendronate; Adverse events; Esophagitis; Prescription event monitoring Abstract: Alendronate sodium is an aminobiphosphonate, an analog of inorganic pyrophosphate, indicated for the treatment of osteoporosis in post-menopausal women. We analyzed events reported in patients prescribed alendronate by general practitioners (GPs) in England. A non-interventional observational cohort study was conducted using the technique of prescription event monitoring (PEM). Exposure data were obtained from dispensed prescriptions issued between October 1995 and January 1997. Outcome data were obtained by sending questionnaires to prescribing GPs. The cohort comprised 11,916 patients. Events most frequently reported as suspected adverse drug reactions and reason for stopping alendronate were recognized gastrointestinal events listed in the Summary of Product Characteristics. These included nausea/vomiting, abdominal pain, dyspepsia, esophagitis and esophageal reflux. Events with the highest incidence density (ID.sub.1 per 1000 patient months treatment) were dyspeptic conditions (32.2), nausea/vomiting (20.8) and abdominal pain (13.8). The term dyspeptic conditions included dyspepsia, esophagitis, esophageal reflux, duodenitis, gastritis and heartburn. Serious suspected adverse reactions possibly related to alendronate were single reports of angioedema, erythema multiforme, hypercalcemia and hypocalcemia. There were 540 deaths in this elderly cohort. This study suggests that alendronate appears to be well tolerated, though there may be risk of developing gastrointestinal side effects including esophagitis and esophageal ulcers. Author Affiliation: (1) Drug Safety Research Unit, Bursledon Hall, Blundell Lane, Southampton, SO31 1AA, UK (2) University of Portsmouth, Portsmouth, UK Article History: Received Date: 11/07/2002 Accepted Date: 24/01/2003 Online Date: 23/04/2003

Published
2003

4. Comparison of incidence rates of cerebrovascular accidents and transienti schaemic attacks in observational cohort studies of patients prescribed risperidone, quetiapine or olanzapine in general practice in England including patients with dementia

Author

Layton, Deborah, Harris, Scott, Wilton, Lynda V., and Shakir, Saad A.W.

Subjects
Risperidone (Medication) -- Complications and side effects -- Dosage and administration, Quetiapine (Medication) -- Complications and side effects -- Dosage and administration, Drug therapy, Complications and side effects, Dosage and administration, Causes of, Dementia -- Drug therapy -- Complications and side effects, Stroke -- Causes of -- Drug therapy -- Complications and side effects, Stroke (Disease) -- Causes of -- Drug therapy -- Complications and side effects
Abstract

Following changes in the safety information on the use of risperidone and olanzapine in elderly patients with dementia, data from prescription-event monitoring (PEM) studies of risperidone, quetiapine and olanzapine were [...]

Published
2005

6. Cardiovascular events in users of sildenafil

Author

Dunn, Nick, Boshier, Andrew, Layton, Deborah, Wilton, Lynda V., Heeley, Emma, and Shakir, Saad A W

Subjects
Viagra (Medication) -- Complications and side effects, Complications and side effects, Risk factors, Heart attack -- Risk factors -- Complications and side effects, Sildenafil -- Complications and side effects
Abstract

Paper does not provide any reassurance EDITOR--Shakir et al investigated the possibility of myocardial infarction being an adverse drug reaction among users of sildenafil.[1] However, their paper suffers from the [...]

Published
2001

7. Cardiovascular events in users of sildenafil: results from first phase of prescription event monitoring in England

Author

Shakir, Saad A W, Wilton, Lynda V., Boshier, Andrew, Layton, Deborah, and Heeley, Emma

Subjects
England -- Health aspects, Complications and side effects, Risk factors, Health aspects, Sildenafil -- Complications and side effects -- Health aspects, Heart attack -- Risk factors -- Complications and side effects -- Health aspects
Abstract

Sildenafil is used to treat erectile dysfunction, and prescription on the NHS is restricted. We are conducting a study of prescription event monitoring for sildenafil in England, the first phase [...]

Published
2001

9. Underreporting of suspected adverse drug reactions to newly marketed ('black triangle') drugs in general practice: observational study

Author

Martin, Richard M., Kapoor, Karan V., Wilton, Lynda V., and Mann, Ronald D.

Subjects
Complications and side effects, Adverse drug reactions -- Complications and side effects, Drugs -- Adverse and side effects
Abstract

Data on side effects of newly launched drugs are limited,[1] highlighting the need for effective postmarketing surveillance. An inverted black triangle (??) on product literature identifies new products. Suspected adverse [...]

Published
1998

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