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Norovirus is the most common cause of acute viral gastroenteritis among adults and children and has no currently approved vaccine (1). Norovirus is genetically diverse and is classified into 10 [...]

Monkeypox virus (MPXV), a double-stranded DNA virus that primarily infects rodents in sub-Saharan Africa, causes mpox disease. MPXV is a member of the genus Orthopoxvirus in the family Poxviridae. MPXV [...]

Noroviruses are the leading cause of sporadic and outbreak-associated, acute, nonbacterial gastroenteritis (1). They are genetically diverse and are classified into 10 genogroups (GI-GX) representing >40 genotypes, although most human [...]

Severe fever with thrombocytopenia syndrome (SFTS) is a tickborne viral disease associated with acute fever, possibly accompanied by vomiting, diarrhea, fatigue, myalgia, and leukocytopenia (1). Most reports of infection have [...]

Norovirus is a major cause of nonbacterial acute gastroenteritis; sporadic cases and outbreaks occur among children and adults (1). Most strains infecting humans belong to genogroups I and II (GI [...]

Norovirus infections are a leading cause of acute gastroenteritis worldwide in persons of all age groups. Despite the broad genetic diversity, norovirus GII.4 has predominated during the past 20 years [...]

A transgenic mouse containing the complete human SLAM (hSLAM/CD150) gene, including its endogenous promoter for transcription, was generated by using human genomic DNA cloned into a bacterial artificial chromosome, hSLAM, the primary receptor for measles viruses (MV), was expressed on activated B, T, and dendritic cells with an expression profile equivalent to that of humans. We demonstrated that hSLA[M.sup.+] cells obtained from the transgenic mouse, including activated B, T, and dendritic cells, were susceptible to MV infection in a receptor-dependent manner. Evidence was provided for transient infection in the nasal lymph nodes of hSLA[M.sup.+] mice after intranasal inoculation. Virus was rapidly cleared without signs of secondary replication. To improve the efficiency of MV production, the hSLA[M.sup.+] mice were bred with mice having a Stat1-deficient background. These mice were more susceptible to MV infection and produced more virus particles. After intranasal and intraperitoneal inoculation of these mice with MV, infections of the thymus, spleen, nasal, mesenteric, and leg lymph nodes were detected. Upon necropsy, enlarged lymph nodes and spleen were apparent. Flow cytometric analysis showed that abnormally large numbers of mature neutrophils and natural killer cells caused the splenomegaly. The hSLAM transgenic mouse constitutes an improved rodent model for studying the interaction of MV with immune cells that more accurately reflects the infection pattern found in humans. activated lymphocytes | transgenic mouse | dendritic cells

To the Editor: Chikungunya fever is a dengue-like syndrome characterized by acute fever, arthralgia, and maculopapular rash. The causative agent is chikungunya virus (CHIKV), which is transmitted by Aedes aegypti [...]

To the Editor: Outbreaks of respiratory enterovirus D68 infection were particularly severe in 2014 in the United States. Wylie et al. recently analyzed the whole genomes of clinical strains from [...]