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A major challenge in the emerging field of toxicogenomics is to define the relationships between chemically induced changes in gene expression and alterations in conventional toxicologic parameters such as clinical [...]

Laboratory animal diets for studies to determine the endocrine-disrupting potential of chemicals are under scrutiny because they can affect both assay control values and assay sensitivity. Although phytoestrogen content is [...]

We used gene expression profiling m investigate whether the molecular effects induced by estrogens of different provenance are intrinsically similar. In this article we show that the physiologic estrogen 17[beta]-estradiol, [...]

While defining the no effect level for the 5[alpha]-reductase inhibitor finasteride in the Hershberger assay, we encountered an inverted-U low-dose trophic effect on the prostate gland of the rat. Two [...]

We have evaluated whether mixtures of estrogens, present in the mix at doses that are individually inactive in the immature rat uterotrophic assay, can give a uterotrophic response. Seven chemicals [...]

The effect of the phytoestrogen coumestrol on ovariectomized rats is examined, focusing on determining the reasons for increased uterine weight in the absence of increased DNA content. Results indicate the activity of phytoestrogen coumestrol and natural estrogen estradiol is similar.

The vomeronasal organ in rodents is an important social and sexual signaling pathway. We have investigated whether the housing of intact immature females in close proximity to mature males would [...]

Makaverich et al. [Environ Health Perspect 103:574-581 (1995)] reported that the uterotrophic activity of the phytoestrogen coumestrol in the immature ovariectomized rat was atypical in that it was not associated [...]

In their paper published in the November 2002 issue of EHP, Cavieres et al. (2002) exposed pregnant mice to a commercial herbicide mixture and determined pregnancy outcomes. Separate experiments were [...]

Markey et al. (1) recently questioned the sensitivity to estrogens of the rodent uterotrophic assay. However, an example of the biological validity of this assay was recently provided by studies [...]