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Your search keyword '"TAYLOR, ANDREW T."' showing total 7 results
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7 results on '"TAYLOR, ANDREW T."'

1. Rhenium analogues of promising renal imaging agents with a [{[super 99m]Tc[(CO).sub.3]}.sup.} core bound to cysteine-derived dipeptides, including lanthionine

Author

Haiyang He, Lipowska, Malgorzata, Xiaolong Xu, Taylor, Andrew T., and Marzilli, Luigi G.

Subjects
Rhenium -- Chemical properties, Technetium -- Isotopes, Technetium -- Chemical properties, Technetium -- Research, Chemistry
Abstract

The synthesis and characterization of Re complexes, which are used for interpreting the nature of tracer [super 99m]Tc radiopharmaceuticals, are described. The chemistry of Re analogues with [LAN.sup.2-]are used for designing new small agents and tagging large agents because two uncoordinated carboxyl groups are available for conjugation with biological molecules such as proteins.

Published
2007

2. Complexes having the fac-{M(CO)3} + core (M = Tc, Re) useful in radiopharmaceuticals: X-ray and NMR structural characterization and density functional calculations of species containing two sp(super 3) N donors and one sp(super 3) O donor

Author

Lipowska, Malgorzata, Cini, Renzo, Tamasi, Gabriella, Xiaolong Xu, Taylor, Andrew T., and Marzilli, Luigi G.

Subjects
Rhenium -- Atomic properties, Rhenium -- Chemical properties, Electron donor-acceptor complexes -- Research, Density functionals -- Usage, Chemistry
Abstract

A study was conducted on the coordination capabilities of ligands (ENDACH2 and ENACH) with aliphatic amines as the only nitrogen donors toward the fac-{M(CO)3} core. Tridentate ligation was observed when two sp(super 3) nitrogen donors and at least one sp(super 3) carboxyl oxygen donor were available.

Published
2004

3. Factors influencing the pK (sub )a of ligated amines and the syn/anti isomerization in cysteine-based Re(V) = O(N (sub)2 S (sub)2) radiopharmaceutical analogues as revealed by a novel dominant tautomer in the solid state

Author

Hansen, Lory, Lipowska, Malgorzata, Melendez, Enrique, Xu, Xiaolong, Hirota, Shun, Taylor, Andrew T., and Marzilli, Luigi G.

Subjects
Chemistry, Inorganic -- Research, Amines -- Research, Isomerization -- Research, Ionization -- Analysis, Chemistry
Abstract

Research has been conducted on the radiopharmaceuticals. The factors leading to one isomeric species in one ionization state at physiological pH are analyzed.

Published
1999

4. Coordination modes of multidentate ligands in fac-[Re[(CO).sub.3](polyaminocarboxylate)] analogues of [super 99m]Tc radiopharmaceuticals: dependence on aqueous solution reaction conditions

Author

Lipowska, Malgorzata, Haiyang He, Xiaolong Xu, Taylor, Andrew T., Marzilli, Patricia A., and Marzilli, Luigi G.

Subjects
Nuclear magnetic resonance spectroscopy -- Usage, Organometallic compounds -- Structure, Organometallic compounds -- Chemical properties, Organometallic compounds -- Thermal properties, Rhenium -- Chemical properties, Rhenium -- Thermal properties, X-ray crystallography -- Usage, Chemistry
Published
2010

5. Re(CO)3 complexes synthesized via an improved preparation of aqueous fac-[Re(CO)3(H2O)3]+ as an aid in assessing (super 99m)Tc imaging agents. Structural characterization and solution behavior of complexes with thioether-bearing amino acids as tridentate ligands

Author

Haiyang He, Lipowska, Malgorzata, Xiaolong Xu, Taylor, Andrew T., Carlone, Maria, and Marzilli, Luigi G.

Subjects
Coordination compounds -- Research, Amino acids -- Chemical properties, Rhenium -- Chemical properties, Chemistry
Abstract

Re(CO)3 complexes with tridentately coordinated alpha-amino acids bearing a thioether group is synthesized by using a new strategy for preparing solution of the fac-[Re(CO)3(H2O)3]+ precursor analogues to the solutions for preparing (super 99m)Tc radiopharmaceuticals. The latter generates an asymmetric center, and NMR and X-ray methods provided evidence for the formation of both possible diastereoisomers, which interchange rapidly in solution except when the thioether has an appended acetate group.

Published
2005

6. Re(V) complexes with an open-chain quadridentate ligand containing two amine and two amido donors. Synthesis, characterization, and solution equilibria of Re(sub 2)O(sub 3)(dioxotetH(sub 4))(sub 2) and [ReO(H(sub 2)O(dioxo-tetH(sub 4)]C1 (dioxotetH(sub 6) = 1,4,8,11-tetraazaundecane-5,7-dione)

Author

Hansen, Lory, Lampeka, Yaroslaw D., Gavrish, Sergey P., Xiaolong Xu, Taylor, Andrew T., and Marzilli, Luigi G.

Subjects
Ligands -- Chemical properties, Rhenium -- Chemical properties, Chemical synthesis, Chemistry
Abstract

A study was conducted to identify mononuclear cationic[M(v)=O](super 3+) (M=Tc,Re) complexes for radiopharmaceutical applications. The open-chain ligand, 1,4,8,11-tetraazaundecane-5,7-dione(dioxo-tetH(sub 6)) with two amine and two amide donors were investigated.

Published
2000

7. Nature of cysteine-based Re(V)=O(N(sub 2)S(sub 2) radiopharmaceutical at physiological pH ascertained by investigation of a new complex with a meso N(sub 2)S(sub 2) ligand having carboxyl groups anti to the oxo group

Author

Hansen, Lory, Hirota, Shun, Xiaolong Xu, Taylor, Andrew T., and Marzilli, Luigi G.

Subjects
Rhenium -- Structure, Rhenium -- Chemical properties, Cysteine -- Chemical properties, Chemistry
Abstract

The factors dictating the structures and the solution chemistry of Re(V)=O(N(sub 2)S(sub 2)) complexes with ligands derived from cysteine (cys)(super 1-8) was investiaged. The study stated that ligand exchange of the isomeric mixture of TMECH(sub 6) with ReIO(sub 2)(PPh(sub 3))(sub 2) resulted in the formation of a mixture of ReO(TIME(H(sub 3)) isomers.

Published
2000

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