1. Coordination of heart and lung co-development by a multipotent cardiopulmonary progenitor
- Author
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Peng, Tien, Tian, Ying, Boogerd, Cornelis J., Lu, Min Min, Kadzik, Rachel S., Stewart, Kathleen M., and Evans, Sylvia M.
- Subjects
Heart -- Genetic aspects -- Physiological aspects ,Lungs -- Genetic aspects -- Physiological aspects ,Environmental issues ,Science and technology ,Zoology and wildlife conservation - Abstract
A population of multipotent cardiopulmonary mesoderm progenitors (CPPs) within the posterior pole of the heart expresses Wnt2, Gli1 and Isl1; these CPPs arise from cardiac progenitors before lung development, generate the mesoderm lineages within the cardiac inflow tract and lung, and are regulated by hedgehog expression from the foregut endoderm. Heart and lung linked by shared progenitor The cardiovascular and respiratory systems require precise co-development to form the gas exchange interface for oxygenation of blood, but how do the heart and lung develop together? Using a series of mouse models to perform both cell-fate and loss-of-function analyses, Edward Morrisey and colleagues have now identified a population of multipotent cardiopulmonary progenitors within the posterior pole of the heart that coordinates heart and lung co-development. The authors propose that the heart and lung have evolved an intricate and precise co-developmental process to ensure postnatal viability of terrestrial animals. Co-development of the cardiovascular and pulmonary systems is a recent evolutionary adaption to terrestrial life that couples cardiac output with the gas exchange function of the lung.sup.1. Here we show that the murine pulmonary vasculature develops even in the absence of lung development. We have identified a population of multipotent cardiopulmonary mesoderm progenitors (CPPs) within the posterior pole of the heart that are marked by the expression of Wnt2, Gli1 and Isl1. We show that CPPs arise from cardiac progenitors before lung development. Lineage tracing and clonal analysis demonstrates that CPPs generate the mesoderm lineages within the cardiac inflow tract and lung including cardiomyocytes, pulmonary vascular and airway smooth muscle, proximal vascular endothelium, and pericyte-like cells. CPPs are regulated by hedgehog expression from the foregut endoderm, which is required for connection of the pulmonary vasculature to the heart. Together, these studies identify a novel population of multipotent cardiopulmonary progenitors that coordinates heart and lung co-development that is required for adaptation to terrestrial existence., Author(s): Tien Peng [sup.1] [sup.2] , Ying Tian [sup.1] [sup.3] , Cornelis J. Boogerd [sup.4] , Min Min Lu [sup.3] , Rachel S. Kadzik [sup.5] , Kathleen M. Stewart [sup.1] [...]
- Published
- 2013
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