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THE COLLECTED WORKS OF THOMAS KYD Volume One BRIAN VICKERS, EDITOR 646pp. Boydell and Brewer. 145 [pounds sterling]. THE COLLECTED WORKS OF JOHN FORD Volume Four BRIAN VICKERS, EDITOR 512pp. [...]

PLAYER KINGS Henry IV Parts 1 and 2, adapted by Robert Icke WILLIAM SHAKESPEARE Noel Coward Theatre, London, until June 22, then touring There's a lovely moment at the end [...]

The Great Basin is home to a variety of avian species but as anthropogenic change continues, land cover change in this region may displace some species. We quantified the amount of land cover change in the Great Basin region between 2001 and 2019, analyzed distribution data derived from the eBird Status and Trends database for 19 raptor species (orders Accipitriformes and Falconiformes), and identified each species' land cover occurrence patterns. Wc discovered that 15 of the raptor species investigated had land cover type as a top-10 predictor lor occupancy. We also observed a large percent change in total cover of water, deciduous forest, mixed forest, shrublands, and grasslands land cover types. The raptor species with land cover in their top-10 predictor list could thus potentially be affected by these land cover change trends. While the complexity of land cover associations are nuanced, we identify patterns of land cover change over almost 2 decades in the Great Basin and reveal species that may be impacted by continued landscape change. These findings can provide crucial information for both habitat management and species conservation. Received 23 February 2021. Accepted 8 June 2022. Key words: anthropogenic change, biodiversity, birds of prey, community science, desertification, land use change. El Great Basin (en el occidente do los Estados Unidos) cs habitat para una variedud de cspecies de aves. aunque el cambio antropogenieo sostenido en la cobertura del suelo en esla region podria desplazar a algunas cspecies. Cuantificamos la suma de cambio en la cobertura del suelo en la region del Great Basin entre 2001 -2019. analizamos la distribution derivada de la base de datos eBird Status and Trends para 19 especies de rapaces (ordenes Accipitriformes y Falconiformes) c identificamos los patrones de presencia por cobertura dc eada especie. Descubrimos que 15 de especies de rapaces que investigamos Icnian la cobertura del suelo eomo una de las 10 principales variables de ocupacion. Tambien observamos un gran porcentaje de cambio en la supcrficie total de los tipos de cobertura agua. bosquc deciduo. hosque mixto. matorral y pradera. Las especies de rapaces con cobertura del suelo en su lista de las 10 principales variables predictivas podrian ser potcncialmcntc alcctadas por esas tendencias en cambio de la cobertura del suelo. Si bicn la complcjidad dc las asociaeiones de cobertura del suelo es ambigua, identificamos patrones de cambio de cobertura a lo largo de ccrca dc 2 decadas en el Great Basin y revelan especies que podrian cstar impactadas por un continue cambio en cl paisajc. l-'stos haitazgos proveen information crucial para el mancjo de habitat y la conservation dc cspecies. i'alahras clave: aves dc presa. cambio antropogenieo, cambio dc uso del suelo, eicneia eomunilaria, desertification., Over time, due to human and natural causes, land use can change. This can result in a given area becoming more or less suitable for a species than it was [...]

THE PERFORMER Art, life, politics RICHARD SENNETT 256pp. Allen Lane. 25 [pounds sterling]. Richard Sennett's The Performer starts small, 'On an AIDS ward'. Sennett's assistant Charles, a theatre director and [...]

SHAKESPEARE WITHOUT A LIFE MARGRETA DE GRAZIA 192pp. Oxford University Press. 25 [pounds sterling] (US $34.95). WILLIAM SHAKESPEARE A brief life PAUL MENZER 280pp. Arden Shakespeare. Paperback, 14.99 [pounds sterling]. [...]

CBL-B is an E3 ubiquitin ligase that ubiquitinates proteins downstream of immune receptors to downregulate positive signaling cascades. Distinct homozygous mutations in CBLB were identified in 3 unrelated children with early-onset autoimmunity, one of whom also had chronic urticaria. Patient T cells exhibited hyperproliferation in response to anti- CD3 cross-linking. One of the mutations, p.R496X, abolished CBL-B expression, and a second mutation, p.C464W, resulted in preserved CBL-B expression. The third mutation, p.H285L in the SH2 domain of CBL-B, was expressed at half the normal level in the patient's cells. Mice homozygous for the CBL-B p.H257L mutation, which corresponds to the patient's p.H285L mutation, had T and B cell hyperproliferation in response to antigen receptor cross-linking. [Cblb.sup.H257L] mice had increased percentages of T regulatory cells (Tregs) that had normal in vitro suppressive function. However, T effector cells from the patient with the p.H285L mutation and [Cblb.sup.H257L] mice were resistant to suppression by WT Tregs. Bone marrow- derived mast cells from [Cblb.sup.H257L] mice were hyperactivated after Fc[epsilon]RI cross-linking, and [Cblb.sup.H257L] mice demonstrated exaggerated IgE-mediated passive anaphylaxis. This study establishes CBL-B deficiency as a cause of immune dysregulation., Introduction The E3 ubiquitin ligase CBL-B is an important regulatory protein highly expressed in immune cells. CBL-B facilitates ubiquitination of receptor-activated signaling proteins, expediting their degradation, and plays an important [...]

COMPLETE WORKS SHAKESPEARE Edited by Richard Proudfoot, Ann Thompson, David Scott Kastan and H. R. Woudhuysen 1,504pp. Arden Shakespeare. Paperback, 21.99 [pounds sterling]. MEASURE FOR MEASURE SHAKESPEARE Edited by A. [...]

SHAKESPEARE IN JEST INDIRA GHOSE 194pp. Routledge. Paperback, 17.99 [pounds sterling]. Shakespeare in Jest offers a pacy, readable account of humour and laughter in Shakespeare's works, from the repartee of [...]

THE TEMPEST SHAKESPEARE Royal Shakespeare Company, Stratford-upon-Avon, until March 4 BY THE TIME Shakespeare came to write The Tempest he had already adopted the mantra 'reduce, reuse, recycle'. At 2,300 [...]

SHAKESPEARE AND BRITISH WORLD WAR TWO FILM GARRETT A. SULLIVAN, JR. 250pp. Cambridge University Press. 75[pounds sterling] (US $99.99). The title of Shakespeare and British World War Two Film immediately [...]

HENRYV SHAKESPEARE Donmar Warehouse, until April 9 The dating of most of Shakespeare's plays is pretty vague, but Henry V is different. In the chorus to Act V, Henry's triumphant [...]

LEARWIFE J. R. THORP 336pp. Canongate. 14.99 [pounds sterling]. When Shakespeare consulted the old chronicle play King Leir (1605), he would have immediately encountered the king's lament for his wife: [...]

OF HUMAN KINDNESS What Shakespeare teaches us about empathy PAULA MARANTZ COHEN 176pp. Yale University Press. 20 [pounds sterling] (US $24). Arguing that Shakespeare makes us better people is always [...]

THE TRAGEDY OF MACBETH Almeida Theatre Long ago, Jack Jorgens, working out a typology for Shakespeare on film, reserved for visionary directors such as Orson Welles and Grigori Kozintsev the [...]

THE COMEDY OF ERRORS SHAKESPEARE Lydia & Manfred Gorvy Garden Theatre, Stratford-upon-Avon, until September 26 THERE'S BEEN MUCH SPECULATION about what Shakespeare might have written during lockdown. We've heard a [...]

BEN JONSON'S THEATRICAL PAEAN TO SHOPPING, his 1609 Entertainment at Britain's Burse composed for the opening of the New Exchange in the presence of James I, opens with a shopboy [...]

How often have you heard yourself, your friends or your siblings utter the immortal words of youth: Its not fair'? But are incidents such as the one quoted above really [...]