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3 results on '"Shapero, Michael H."'

1. Global variation in copy number in the human genome

Author

Redon, Richard, Ishikawa, Shumpei, Fitch, Karen R., Feuk, Lars, Perry, George H., Andrews, T. Daniel, Fiegler, Heike, Shapero, Michael H., Carson, Andrew R., Chen, Wenwei, Cho, Eun Kyung, Dallaire, Stephanie, Freeman, Jennifer L., Gonzalez, Juan R., Gratacos, Monica, Huang, Jing, Kalaitzopoulos, Dimitrios, Komura, Daisuke, MacDonald, Jeffrey R., Marshall, Christian R., Mei, Rui, Montgomery, Lyndal, Nishimura, Kunihiro, Okamura, Kohji, Shen, Fan, Somerville, Martin J., Tchinda, Joelle, Valsesia, Armand, Woodwark, Cara, Yang, Fengtang, Zhang, Junjun, Zerjal, Tatiana, Zhang, Jane, Armengol, Lluis, Conrad, Donald F., Estivill, Xavier, Tyler-Smith, Chris, Carter, Nigel P., Aburatani, Hiroyuki, Lee, Charles, Jones, Keith W., Scherer, Stephen W., and Hurles, Matthew E.

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Richard Redon [1]; Shumpei Ishikawa [2, 3]; Karen R. Fitch [4]; Lars Feuk [5, 6]; George H. Perry [7]; T. Daniel Andrews [1]; Heike Fiegler [1]; Michael H. Shapero [...]

Published
2006
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2. Exon sequence and structure requirements for tRNA splicing in Saccharomyces cerevisae

Author

Shapero, Michael H. and Greer, Chris L.

Subjects
RNA splicing -- Research, Microbial genetics -- Research, Saccharomyces -- Research, Biological sciences, Chemistry
Abstract

tRNA splicing in Saccharomyces cerevisae was studied in terms of exon sequence and structural prerequisites for the process using in vitro prepared pre-tRNA substrates. The findings revealed that not all features of exon sequences or structure are recognized by the splicing enzymes. These showed the importance of formation of base-pairs in splicing regardless of primary sequences. Endonuclease excision became more efficient with altered primary sequence with retention of secondary structure of the aminoacyl stem. These effects may be indirect through structural modifications.

Published
1992

3. High-resolution analysis of DNA copy number using oligonucleotide microarrays

Author

Bignell, Graham R., Watt, Stephen, Grigorova, Mira, Shapero, Michael H., Greshock, Joel, Huang, Jing, West Sofie, Butler, Adam, Wei, Wen, Jones, Keith W., and Wooster, Richard

Subjects
Cancer cells -- Research, Human genetics -- Research, Genotype -- Research, Genomics -- Research, DNA microarrays -- Research, Health
Abstract

Genomic copy number alterations are a feature of many human diseases including cancer. The effectiveness of an oligonucleotide array to assess DNA copy number is evaluated. The combination of the genotype and copy number analyses helps in identification of complex events including loss and reduplication of loci and gives greater insight into the underlying genetic alterations in cancer cells.

Published
2004

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