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A single blind clinical trial is conducted involving 162 women with systemic lupus erythematosus who were randomly assigned to combined oral contraceptives, a progestin-only pill or a copper intrauterine device (IUD). Results show that although estrogen-containing oral-contraceptive regimen do not appear to increase the risk of disease exacerbation in women with systemic lupus erythematosus, one should still be cautious about the possibility of an increased risk of thrombosis with hormonal methods of contraception.