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2. Human IAPP is a contributor to painful diabetic peripheral neuropathy

Author

Albariqi, Mohammed M.H., Versteeg, Sabine, Brakkee, Elisabeth M., Coert, J. Henk, Elenbaas, Barend O.W., Prado, Judith, Hack, C. Erik, Hoppener, Jo W.M., and Eijkelkamp, Niels

Subjects
Diabetes -- Diagnosis -- Complications and side effects, Pancreatic beta cells -- Analysis, Health care industry
Abstract

Peripheral neuropathy is a frequent complication of type 2 diabetes mellitus (T2DM). We investigated whether human islet amyloid polypeptide (hIAPP), which forms pathogenic aggregates that damage pancreatic islet [beta] cells in T2DM, is involved in T2DM-associated peripheral neuropathy. In vitro, hIAPP incubation with sensory neurons reduced neurite outgrowth and increased levels of mitochondrial reactive oxygen species. hIAPP-transgenic mice, which have elevated plasma hIAPP levels without hyperglycemia, developed peripheral neuropathy as evidenced by pain-associated behavior and reduced intraepidermal nerve fiber (IENF) density. Similarly, hIAPP Ob/Ob mice, which have hyperglycemia in combination with elevated plasma hIAPP levels, had signs of neuropathy, although more aggravated. In wild-type mice, intraplantar and intravenous hIAPP injections induced long-lasting allodynia and decreased IENF density. Non-aggregating murine IAPP, mutated hIAPP (pramlintide), or hIAPP with pharmacologically inhibited aggregation did not induce these effects. T2DM patients had reduced IENF density and more hIAPP oligomers in the skin compared with non-T2DM controls. Thus, we provide evidence that hIAPP aggregation is neurotoxic and mediates peripheral neuropathy in mice. The increased abundance of hIAPP aggregates in the skin of T2DM patients supports the notion that hIAPP is a potential contributor to T2DM neuropathy in humans., Introduction Diabetes mellitus (DM) is a metabolic disorder that affects around 463 million individuals globally (1). DM is one of the most significant worldwide health issues, diminishing quality of life [...]

Published
2023
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6. Gottingen University Medical Center Researchers Discuss Research in Alzheimer Disease (Effects of pharmacological modulators of a-synuclein and tau aggregation and internalization)

Subjects
Physical fitness -- Research -- Reports, Medical centers -- Research -- Reports, Medical research -- Reports, Alzheimer's disease -- Research, Health
Abstract

2020 AUG 22 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Research findings on Alzheimer disease are discussed in a new report. According [...]

Published
2020

7. Data on Alzheimer Disease Described by Researchers at University Medical Centre Goettingen (Effects of Pharmacological Modulators of Alpha-synuclein and Tau Aggregation and Internalization)

Subjects
Medical research -- Analysis, Medicine, Experimental -- Analysis, Medical centers -- Analysis, Alzheimer's disease -- Analysis, Health
Abstract

2021 MAR 19 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Data detailed on Neurodegenerative Diseases and Conditions - Alzheimer Disease have been presented. [...]

Published
2021

9. Germany : Max Planck Society grants license for new drug candidates

Subjects
Associations, Neurons, Technology, Business, international
Abstract

The protein alpha-synuclein is deposited in the brain of patients with Parkinsons disease or multi-system atrophy at the onset of the disease. Oligomeric deposits have a particularly toxic effect on [...]

Published
2019

10. Studies from Medical University of Innsbruck Add New Findings in the Area of Multiple System Atrophy [Targeting Alpha-synuclein By Pd03 Affitope ® and Anle138b Rescues Neurodegenerative Pathology In a Model of Multiple System Atrophy: Clinical ...]

Subjects
Neurophysiology -- Reports -- Research, Immunotherapy -- Reports -- Research, Multiple system atrophy -- Research, Nervous system diseases -- Research, Health
Abstract

2020 NOV 4 (NewsRx) -- By a News Reporter-Staff News Editor at Immunotherapy Weekly -- Investigators publish new report on Neurodegenerative Diseases and Conditions - Multiple System Atrophy. According to [...]

Published
2020

11. New Multiple System Atrophy Study Findings Have Been Published by Researchers at Innsbruck Medical University [Targeting a-synuclein by PD03 AFFITOPE® and Anle138b rescues neurodegenerative pathology in a model of multiple system atrophy: ...]

Subjects
Neurophysiology -- Reports -- Research, Immunotherapy -- Reports -- Research, Multiple system atrophy -- Research, Health
Abstract

2020 OCT 14 (NewsRx) -- By a News Reporter-Staff News Editor at Immunotherapy Weekly -- New study results on multiple system atrophy have been published. According to news reporting from [...]

Published
2020

12. Studies Conducted at University Medical Centre Goettingen on Alzheimer Disease Recently Reported (Effects of Pharmacological Modulators of Alpha-synuclein and Tau Aggregation and Internalization)

Subjects
Medical centers -- Analysis, Alzheimer's disease -- Analysis, Health
Abstract

2020 SEP 11 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators publish new report on Neurodegenerative Diseases and Conditions - Alzheimer Disease. According [...]

Published
2020

13. Researchers from Max-Planck-Institute for Biophysical Chemistry Report Details of New Studies and Findings in the Area of Nerve Tissue Proteins (11 C Radiolabeling of anle253b: a Putative PET Tracer for Parkinson's Disease That Binds to ...)

Subjects
Tracers (Biology) -- Reports, Nerve tissue proteins -- Reports, Biological sciences, Health
Abstract

2020 SEP 8 (NewsRx) -- By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Proteins - Nerve Tissue Proteins. According to news reporting [...]

Published
2020

14. Researchers from University of Utrecht Discuss Research in Amyloid (The small molecule inhibitor anle145c thermodynamically traps human islet amyloid peptide in the form of non-cytotoxic oligomers)

Subjects
Thermodynamics -- Reports, Glycoproteins -- Reports, Oligomers -- Reports, Type 2 diabetes -- Research -- Reports, Peptides -- Reports, Editors, Biological sciences, Health
Abstract

2019 DEC 31 (NewsRx) -- By a News Reporter-Staff News Editor at Life Science Weekly -- New study results on amyloid have been published. According to news reporting from the [...]

Published
2019

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