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1. Genomic rearrangements of hMSH6 contribute to the genetic predisposition in suspected hereditary non-polyposis colorectal cancer syndrome

Author

Plaschke, J, Ruschoff, J, and Schackert, HK

Subjects
Gene mutations -- Analysis -- Research -- Genetic aspects, Genetic disorders -- Research -- Genetic aspects, Colorectal cancer -- Genetic aspects -- Research, Health, Analysis, Genetic aspects, Research
Abstract

Background: Germline mutations in mismatch repair genes, mainly in hMLH1, hMSH2, and hMSH6, predispose to the hereditary non-polyposis colorectal cancer (HNPCC) syndrome. A substantial fraction of these mutations exists in [...]

Published
2003

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