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Byline: M. T. Pellecchia (1), A. Grasso (1), L. G. Biancardi (1), M. Squillante (1), V. Bonavita (1), P. Barone (1) Keywords: Parkinson's disease; long-term rehabilitation; UPDRS; depression Abstract: Abstract. The aim of this study was to evaluate the effects of prolonged physical therapy on disability in patients with Parkinson's disease. The study was designed as an open long-term trial over 20 weeks. Twenty slightly to moderately affected parkinsonian patients were included (Hoehn &amp Yahr stages: 1.5--3). A comprehensive rehabilitation program was applied three times a week in all patients. Pharmacological treatment was kept stable. Evaluations were performed at baseline, at the end of treatment and after 3 months. Following physical rehabilitation, there was a significant improvement in UPDRS (ADL and motor sections) scores, Self-assessment Parkinson's disease Disability Scale, Ten-Meter Walk test and Zung scale for depression. At 3-month follow-up clinical improvements were largely maintained. A sustained improvement of motor skills in PD patients can be achieved with a long-term comprehensive rehabilitation program. Author Affiliation: (1) Department of Neurological Sciences, University 'Federico II', Ed. 17, Via Pansini 5, 80131, Naples, Italy Article History: Registration Date: 01/01/2004 Received Date: 21/07/2003 Accepted Date: 15/12/2003