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3 results on '"Parry, Mikko"'

1. Introduction and Rapid Spread of SARS-CoV-2 Omicron Variant and Dynamics of BA.1 and BA.1.1 Sublineages, Finland, December 2021

Author

Vauhkonen, Hanna, Nguyen, Phuoc Truong, Kant, Ravi, Plyusnin, Ilja, Erdin, Mert, Kurkela, Satu, Liimatainen, Hanna, Ikonen, Niina, Blomqvist, Soile, Liitsola, Kirsi, Lindh, Erika, Helve, Otto, Jarva, Hanna, Loginov, Raisa, Palva, Aino, Hannunen, Tiina, Hannula, Sari, Parry, Mikko, Kauppi, Paula, Vaheri, Antti, Sironen, Tarja, Lappalainen, Maija, Savolainen-Kopra, Carita, Smura, Teemu, and Vapalahti, Olli

Subjects
Epidemics -- Statistics -- Causes of -- Finland, Company distribution practices, Health
Abstract

The most recent SARS-CoV-2 variant of concern, Omicron (Pango lineage B.1.1.529), was first detected in South Africa (1), although it might have emerged elsewhere, and has since spread globally at [...]

Published
2022
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2. High-affinity small molecule-phospholipid complex formation: binding of siramesine to phosphatidic acid

Author

Parry, Mikko J., Alakoskela, Juha-Matti I., Khandelia, Himanshu, Kumar, Subramanian Arun, Jaattela, Maria, Mahalka, Ajay K., and Kinnunen, Paavo K.J.

Subjects
Phospholipids -- Structure, Phospholipids -- Chemical properties, Antimitotic agents -- Chemical properties, Antimitotic agents -- Research, Antineoplastic agents -- Chemical properties, Antineoplastic agents -- Research, Fluorescence spectroscopy -- Usage, Chemistry
Abstract

The interactions of siramesine (SRM) are studied with model biomembranes composed of zwitterionic and anionic phospholipids by using fluorescence spectroscopy. The key role of phosphatidic acid (PA) as a signaling molecule promoting cell growth is considered for showing a new paradigm for the development of anticancer drugs.

Published
2008

3. Counterion-controlled transition of a cationic gemini from submicroscopic to giant vesicles

Author

Ryhanen, Samppa, Alakoskela, Juha-Matti I., Kinnunen, Paavo K.J., Sally, V. Matti J., Parry, Mikko J., Luciani, Paola, and Mancini, Giovanna

Subjects
Lattice dynamics -- Research, Chemistry
Abstract

The sharp and reversible transition of a cationic gemini lipid from small vesicles with an average diameter of approximately 40 nm to giant vesicles with an average diameter of approximately 11 (mu)m is demonstrated. A novel mechanism is proposed whereby a specific interaction of [Cl.sup.-] counterion with the cationic gemini surfactant initiates the formation of a commensurate solute counterion lattice with low spontaneous curvature.

Published
2006

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