To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ajog.2006.10.868 Byline: Graeme N. Smith (1), Mark C. Walker (2), Arne Ohlsson (3)(4), Karel O'Brien (3), Rory Windrim (4) Keywords: morbidity; neonate; pregnancy; premature; preterm labor; tocolytic Abstract: Despite advances in perinatal medicine, the incidence of preterm birth continues to increase. The primary goal of tocolytic therapy is to reduce neonatal morbidity and mortality. While studies have demonstrated a prolongation of pregnancy, no tocolytic has been shown to improve neonatal outcomes. The objective of this randomized placebo-controlled trial was to determine the effect of transdermal nitroglycerin on neonatal outcomes in women who present in preterm labor. Author Affiliation: (1) Queen's Perinatal Research Unit, Department of Obstetrics and Gynecology, Kingston General Hospital, Queen's University, Kingston, Ontario (2) Ottawa Maternal Neonatal Investigators, Department of Obstetrics and Gynecology, Ottawa General Hospital, University of Ottawa, Ottawa (3) Department of Pediatrics, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada (4) Department of Obstetrics and Gynecology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada. Article History: Received 25 May 2006; Revised 1 September 2006; Accepted 11 October 2006 Article Note: (footnote) This study was funded by grants from the Canadian Institutes for Health Research (CIHR) (MCT 41550) and by the Physicians of Ontario through the Physicians' Services Incorporated (PSI) Foundation, North York, Ontario, Canada. Drs Smith and Walker are supported by CIHR New Investigators Awards. Cite this article as: Smith GN, Walker MC, Ohlsson A, et al. Randomized double-blind placebo-controlled trial of transdermal nitroglycerin for preterm labor. Am J Obstet Gynecol 2007;196:37.e1-37.e8.