1. Synthesis of PGB1 analogues by radical chain substitution reaction
- Author
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Rui Tamura, Masatoshi Kohno, Sei Utsunomiya, Kunihiko Yamawaki, Nagao Azuma, Akira Matsumoto, and Yasutaka Ishii
- Subjects
Phospholipases -- Analysis ,Oxidation-reduction reaction -- Observations ,Biological sciences ,Chemistry - Abstract
The synthesis of PGB1 analogues, characterized by a sulfur atom-containing alpha-side chains, proceeds in several steps from 1, 3-cyclopentanedione. The substitution of an allylic sulfonyl group in 3-substituted 2-((phenylsulfony)methyl)-2-cyclopenten-1-one is achieved by stabilized carbanions or thiolate ions and palladium (Pd)-catalyzed cross-linking reaction between the vinylic iodide moiety in 2-substituted 3-iodo-2-cyclopenten-1-ones and a vinyltin reagent or alkyne. This substitution reaction results in the incorporation of an alpha or omega-side chains into the PGB1 cyclopentanedione backbone.
- Published
- 1993