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1. Lopinavir/ritonavir as single-drug therapy for maintenance of HIV-1 viral suppression: 48-week results of a randomized, controlled, open-label, proof-of-concept pilot clinical trial (OK Study)

Author

Arribas, Jose R., Delgado, Rafeal, Miralles, Pilar, Gonzalez-Garcia, Juan J., Pano, Jose R., Gaya, Francisco, Carcas, Antonio, Montes, Maria L., Costa, Jose R., Pena, Jose M., Pulido, Federico, Lorenzo, Alicia, Arranz, Alberto, and Cepeda, Concepcion

Subjects
HIV infection -- Care and treatment, HIV infection -- Genetic aspects, Ritonavir -- Dosage and administration, Antiviral agents -- Dosage and administration, Health, Iopidine (Medication) -- Dosage and administration
Abstract

The maintenance with Iopinavir/ritonavir monotherapy vs. continuing Iopinavir/ritonavir and 2 nucleosides in Human Immunodeficiency Virus (HIV)-infected patients with suppresses HIV replication is evaluated. The results reveal that the failure of Iopinavir/ritronavir monotherapy are not associated with the development of primary resistance mutations in the protease gene and could be successfully reinduced adding back prior nucleosides.

Published
2005

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