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2. Strong constraints on aerosolcloud interactions from volcanic eruptions

Author

Malavelle, Florent F., Haywood, Jim M., Jones, Andy, Gettelman, Andrew, Clarisse, Lieven, Bauduin, Sophie, Allan, Richard P., Karset, Inger Helene H., Kristjnsson, Jn Egill, Oreopoulos, Lazaros, Cho, Nayeong, Lee, Dongmin, Bellouin, Nicolas, Boucher, Olivier, Grosvenor, Daniel P., Carslaw, Ken S., Dhomse, Sandip, Mann, Graham W., Schmidt, Anja, Coe, Hugh, Hartley, Margaret E., Dalvi, Mohit, Hill, Adrian A., Johnson, Ben T., Johnson, Colin E., Knight, Jeff R., OConnor, Fiona M., Partridge, Daniel G., Stier, Philip, Myhre, Gunnar, Platnick, Steven, Stephens, Graeme L., Takahashi, Hanii, and Thordarson, Thorvaldur

Subjects
Aerosols -- Environmental aspects, Clouds (Meteorology) -- Environmental aspects, Volcanoes -- Environmental aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Aerosols have a potentially large effect on climate, particularly through their interactions with clouds, but the magnitude of this effect is highly uncertain. Large volcanic eruptions produce sulfur dioxide, which in turn produces aerosols; these eruptions thus represent a natural experiment through which to quantify aerosolcloud interactions. Here we show that the massive 20142015 fissure eruption in Holuhraun, Iceland, reduced the size of liquid cloud dropletsconsistent with expectationsbut had no discernible effect on other cloud properties. The reduction in droplet size led to cloud brightening and global-mean radiative forcing of around 0.2 watts per square metre for September to October 2014. Changes in cloud amount or cloud liquid water path, however, were undetectable, indicating that these indirect effects, and cloud systems in general, are well buffered against aerosol changes. This result will reduce uncertainties in future climate projections, because we are now able to reject results from climate models with an excessive liquid-water-path response., Author(s): Florent F. Malavelle (corresponding author) [1]; Jim M. Haywood [1, 2]; Andy Jones [2]; Andrew Gettelman [3]; Lieven Clarisse [4]; Sophie Bauduin [4]; Richard P. Allan [5, 6]; Inger [...]

Published
2017
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3. Whole-genome landscapes of major melanoma subtypes

Author

Hayward, Nicholas K., Wilmott, James S., Waddell, Nicola, Johansson, Peter A., Field, Matthew A., Nones, Katia, Patch, Ann-Marie, Kakavand, Hojabr, Alexandrov, Ludmil B., Burke, Hazel, Jakrot, Valerie, Kazakoff, Stephen, Holmes, Oliver, Leonard, Conrad, Sabarinathan, Radhakrishnan, Mularoni, Loris, Wood, Scott, Xu, Qinying, Waddell, Nick, Tembe, Varsha, Pupo, Gulietta M., De Paoli-Iseppi, Ricardo, Vilain, Ricardo E., Shang, Ping, Lau, Loretta M. S., Dagg, Rebecca A., Schramm, Sarah-Jane, Pritchard, Antonia, Dutton-Regester, Ken, Newell, Felicity, Fitzgerald, Anna, Shang, Catherine A., Grimmond, Sean M., Pickett, Hilda A., Yang, Jean Y., Stretch, Jonathan R., Behren, Andreas, Kefford, Richard F., Hersey, Peter, Long, Georgina V., Cebon, Jonathan, Shackleton, Mark, Spillane, Andrew J., Saw, Robyn P. M., Lpez-Bigas, Nria, Pearson, John V., Thompson, John F., Scolyer, Richard A., and Mann, Graham J.

Subjects
Genetic research, Genomes -- Research, Melanoma -- Genetic aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Melanoma of the skin is a common cancer only in Europeans, whereas it arises in internal body surfaces (mucosal sites) and on the hands and feet (acral sites) in people throughout the world. Here we report analysis of whole-genome sequences from cutaneous, acral and mucosal subtypes of melanoma. The heavily mutated landscape of coding and non-coding mutations in cutaneous melanoma resolved novel signatures of mutagenesis attributable to ultraviolet radiation. However, acral and mucosal melanomas were dominated by structural changes and mutation signatures of unknown aetiology, not previously identified in melanoma. The number of genes affected by recurrent mutations disrupting non-coding sequences was similar to that affected by recurrent mutations to coding sequences. Significantly mutated genes included BRAF, CDKN2A, NRAS and TP53 in cutaneous melanoma, BRAF, NRAS and NF1 in acral melanoma and SF3B1 in mucosal melanoma. Mutations affecting the TERT promoter were the most frequent of all; however, neither they nor ATRX mutations, which correlate with alternative telomere lengthening, were associated with greater telomere length. Most melanomas had potentially actionable mutations, most in components of the mitogen-activated protein kinase and phosphoinositol kinase pathways. The whole-genome mutation landscape of melanoma reveals diverse carcinogenic processes across its subtypes, some unrelated to sun exposure, and extends potential involvement of the non-coding genome in its pathogenesis., Author(s): Nicholas K. Hayward [1, 2]; James S. Wilmott [1, 3]; Nicola Waddell [2, 4]; Peter A. Johansson [2]; Matthew A. Field [5]; Katia Nones [2, 4]; Ann-Marie Patch [2, [...]

Published
2017
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4. Genome-wide association study identifies novel breast cancer susceptibility loci

Author

Easton, Douglas F., Pooley, Karen A., Dunning, Alison M., Pharoah, Paul D. P., Thompson, Deborah, Ballinger, Dennis G., Struewing, Jeffery P., Morrison, Jonathan, Field, Helen, Luben, Robert, Wareham, Nicholas, Ahmed, Shahana, Healey, Catherine S., Bowman, Richard, Luccarini, Craig, Conroy, Don, Shah, Mitul, Munday, Hannah, Jordan, Clare, Perkins, Barbara, West, Judy, Redman, Karen, Driver, Kristy, Meyer, Kerstin B., Haiman, Christopher A., Kolonel, Laurence K., Henderson, Brian E., Le Marchand, Loic, Brennan, Paul, Sangrajrang, Suleeporn, Gaborieau, Valerie, Odefrey, Fabrice, Shen, Chen-Yang, Wu, Pei-Ei, Wang, Hui-Chun, Eccles, Diana, Evans, D. Gareth, Peto, Julian, Fletcher, Olivia, Johnson, Nichola, Seal, Sheila, Stratton, Michael R., Rahman, Nazneen, Chenevix-Trench, Georgia, Bojesen, Stig E., Nordestgaard, Borge G., Axelsson, Christen K., Garcia-Closas, Montserrat, Brinton, Louise, Chanock, Stephen, Lissowska, Jolanta, Peplonska, Beata, Nevanlinna, Heli, Fagerholm, Rainer, Eerola, Hannaleena, Kang, Daehee, Yoo, Keun-Young, Noh, Dong-Young, Ahn, Sei-Hyun, Hunter, David J., Hankinson, Susan E., Cox, David G., Hall, Per, Wedren, Sara, Liu, Jianjun, Low, Yen-Ling, Bogdanova, Natalia, Schurmann, Peter, Dork, Thilo, Tollenaar, Rob A. E. M., Jacobi, Catharina E., Devilee, Peter, Klijn, Jan G. M., Sigurdson, Alice J., Doody, Michele M., Alexander, Bruce H., Zhang, Jinghui, Cox, Angela, Brock, Ian W., MacPherson, Gordon, Reed, Malcolm W. R., Couch, Fergus J., Goode, Ellen L., Olson, Janet E., Meijers-Heijboer, Hanne, van den Ouweland, Ans, Uitterlinden, Andre, Rivadeneira, Fernando, Milne, Roger L., Ribas, Gloria, Gonzalez-Neira, Anna, Benitez, Javier, Hopper, John L., McCredie, Margaret, Southey, Melissa, Giles, Graham G., Schroen, Chris, Justenhoven, Christina, Brauch, Hiltrud, Hamann, Ute, Ko, Yon-Dschun, Spurdle, Amanda B., Beesley, Jonathan, Chen, Xiaoqing, Aghmesheh, Morteza, Amor, David, Andrews, Lesley, Antill, Yoland, Armes, Jane, Armitage, Shane, Arnold, Leanne, Balleine, Rosemary, Begley, Glenn, Beilby, John, Bennett, Ian, Bennett, Barbara, Berry, Geoffrey, Blackburn, Anneke, Brennan, Meagan, Brown, Melissa, Buckley, Michael, Burke, Jo, Butow, Phyllis, Byron, Keith, Callen, David, Campbell, Ian, Clarke, Christine, Colley, Alison, Cotton, Dick, Cui, Jisheng, Culling, Bronwyn, Cummings, Margaret, Dawson, Sarah-Jane, Dixon, Joanne, Dobrovic, Alexander, Dudding, Tracy, Edkins, Ted, Eisenbruch, Maurice, Farshid, Gelareh, Fawcett, Susan, Field, Michael, Firgaira, Frank, Fleming, Jean, Forbes, John, Friedlander, Michael, Gaff, Clara, Gardner, Mac, Gattas, Mike, George, Peter, Giles, Graham, Gill, Grantley, Goldblatt, Jack, Greening, Sian, Grist, Scott, Haan, Eric, Harris, Marion, Hart, Stewart, Hayward, Nick, Hopper, John, Humphrey, Evelyn, Jenkins, Mark, Jones, Alison, Kefford, Rick, Kirk, Judy, Kollias, James, Kovalenko, Sergey, Lakhani, Sunil, Leary, Jennifer, Lim, Jacqueline, Lindeman, Geoff, Lipton, Lara, Lobb, Liz, Maclurcan, Mariette, Mann, Graham, Marsh, Deborah, McKay, Michael, Anne McLachlan, Sue, Meiser, Bettina, Milne, Roger, Mitchell, Gillian, Newman, Beth, O'Loughlin, Imelda, Osborne, Richard, Peters, Lester, Phillips, Kelly, Price, Melanie, Reeve, Jeanne, Reeve, Tony, Richards, Robert, Rinehart, Gina, Robinson, Bridget, Rudzki, Barney, Salisbury, Elizabeth, Sambrook, Joe, Saunders, Christobel, Scott, Clare, Scott, Elizabeth, Scott, Rodney, Seshadri, Ram, Shelling, Andrew, Spurdle, Amanda, Suthers, Graeme, Taylor, Donna, Tennant, Christopher, Thorne, Heather, Townshend, Sharron, Tucker, Kathy, Tyler, Janet, Venter, Deon, Visvader, Jane, Walpole, Ian, Ward, Robin, Waring, Paul, Warner, Bev, Warren, Graham, Watson, Elizabeth, Williams, Rachael, Wilson, Judy, Winship, Ingrid, Young, Mary Ann, Bowtell, David, Green, Adele, deFazio, Anna, Gertig, Dorota, Webb, Penny, Mannermaa, Arto, Kosma, Veli-Matti, Kataja, Vesa, Hartikainen, Jaana, Day, Nicholas E., Cox, David R., and Ponder, Bruce A. J.

Subjects
Genetic susceptibility -- Research -- Genetic aspects, Breast cancer -- Genetic aspects -- Risk factors -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation, Genetic aspects, Research, Risk factors
Abstract

Author(s): Douglas F. Easton (corresponding author) [1]; Karen A. Pooley [2]; Alison M. Dunning [2]; Paul D. P. Pharoah [2]; Deborah Thompson [1]; Dennis G. Ballinger [3]; Jeffery P. Struewing [...]

Published
2007
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5. Localization of a novel melanoma susceptibility locus to 1p22

Author

Gillanders, Elizabeth, Juo, Suh-Hang Hank, Holland, Elizabeth A., Jones, MaryPat, Nancarrow, Derek, Freas-Lutz, Diana, Sood, Raman, Park, Naeun, Faruque, Mezbah, Markey, Carol, Kefford, Richard F., Palmer, Jane, Bergman, Wilma, Bishop, D. Timothy, Tucker, Margaret A., Bressac-de Paillerets, Brigitte, Hansson, Johan, Stark, Mitchell, Gruis, Nelleke, Bishop, Julia Newton, Goldstein, Alisa M., Bailey-Wilson, Joan E., Mann, Graham J., Hayward, Nicholas, and Trent, Jeffrey

Subjects
Melanoma -- Research, Biological sciences
Published
2003

6. Evaluation of linkage of breast cancer to the putative BRCA3 locus on chromosome 13q21 in 128 multiple case families from the Breast Cancer Linkage Consortium

Author

Thompson, Deborah, Szabo, Csilla I., Mangion, Jon, Oldenburg, Rogier A., Odefrey, Fabrice, Seal, Sheila, Barfoot, Rita, Kroeze-Jansema, Karin, Teare, Dawn, Rahman, Nazneen, Renard, Helene, Consortium, KConFab, Mann, Graham, Hopper, John L., Buys, Saundra S., Andrulis, Irene L., Senie, Ruby, Daly, Mary B., West, Dee, Ostrander, Elaine A., Offit, Ken, Peretz, Tamar, Osorio, Ana, Benitez, J., Nathanson, Katherine L., Sinilnikova, Olga M., Olah, Edith, Bignon, Yves-Jean, Ruiz, Pablo, Badzioch, Michael D., Vasen, Hans F. A., Futreal, Andrew P., Phelan, Catherine M., Narod, Steven A., Lynch, Henry T., Ponder, Bruce A. J., Eeles, Ros A., Meijers-Heijboer, Hanne, Stoppa-Lyonnet, Dominique, Couch, Fergus J., Eccles, Diana M., Evans, D. Gareth, Chang-Claude, Jenny, Lenoir, Gilbert, Weber, Barbara L., Devilee, Peter, Easton, Douglas F., Goldgar, David E., and Stratton, Michael R.

Subjects
Cytochemistry -- Research, Breast cancer -- Genetic aspects, Familial diseases -- Research, Science and technology
Abstract

The known susceptibility genes for breast cancer, including BRCA1 and BRCA2, only account for a minority of the familial aggregation of the disease. A recent study of 77 multiple case breast cancer families from Scandinavia found evidence of linkage between the disease and polymorphic markers on chromosome 13q21. We have evaluated the contribution of this candidate 'BRCA3' locus to breast cancer susceptibility in 128 high-risk breast cancer families of Western European ancestry with no identified BRCA1 or BRCA2 mutations. No evidence of linkage was found. The estimated proportion ([alpha]) of families linked to a susceptibility locus at D13S1308, the location estimated by Kainu et al. [(2000) Proc. Natl. Acad. Sci. USA 97, 9603-9608], was 0 (upper 95% confidence limit 0.13). Adjustment for possible bias due to selection of families on the basis of linkage evidence at BRCA2 did not materially alter this result ([alpha] = 0, upper 95% confidence limit 0.18). The proportion of linked families reported by Kainu et al. (0.65) is excluded with a high degree of confidence in our dataset [heterogeneity logarithm of odds (HLOD) at [alpha] = 0.65 was -11.0]. We conclude that, if a susceptibility gene does exist at this locus, it can only account for a small proportion of non-BRCA1/2 families with multiple cases of early-onset breast cancer.

Published
2002

8. Features associated with germline CDKN2A mutations: a GenoMEL study of melanoma-prone families from three continents

Author

Goldstein, Alisa M., Chan, May, Harland, Mark, Hayward, Nicholas K., Demenais, Florence, Bishop, D. Timothy, Azizi, Esther, Bergman, Wilma, Bianchi-Scarra, Giovanna, Bruno, William, Calista, Donato, Albright, Lisa A. Cannon, Chaudru, Valerie, Chompret, Agnes, Cuellar, Francisco, Elder, David E., Ghiorzo, Paola, Gillanders, Elizabeth M., Gruis, Nelleke A., Hansson, Johan, Hogg, David, Holland, Elizabeth A., Kanetsky, Peter A., Kefford, Richard F., Landi, Maria Teresa, Lang, Julie, Leachman, Sancy A., MacKie, Rona M., Magnusson, Veronica, Mann, Graham J., Bishop, Julia Newton, Palmer, Jane M., Puig, Susana, Puig-Butille, Joan A., Stark, Mitchell, Tsao, Hensin, Tucker, Margaret A., Whitaker, Linda, and Yakobson, Emanuel

Subjects
Melanoma -- Research, Melanoma -- Risk factors, Melanoma -- Genetic aspects, Melanoma -- Demographic aspects, Gene mutations -- Research, Gene mutations -- Health aspects, Health
Published
2007

9. Geographical variation in the penetrance of CDKN2A mutations for melanoma

Author

Bishop, D. Timothy, Demenais, Florence, Goldstein, Alisa M., Bergman, Wilma, Newton Bishop, Julia, Bressac-de Paillerets, Brigitte, Chompret, Agnes, Ghiorzo, Paola, Gruis, Nelleke, Hansson, Johan, Harland, Mark, Hayward, Nicholas, Holland, Elizabeth A., Mann, Graham J., Mantelli, Michela, Nancarrow, Derek, Platz, Anton, and Tucker, Margaret A.

Subjects
Melanoma -- Genetic aspects, Gene mutations -- Analysis, Disease susceptibility -- Causes of, Health
Abstract

Background: Germline mutations in the CDKN2A gene, which encodes two proteins (p16INK4A and p14ARF), are the most common cause of inherited susceptibility to melanoma. We examined the penetrance of such mutations using data from eight groups from Europe, Australia and the United States that are part of The Melanoma Genetics Consortium. Methods: We analyzed 80 families with documented CDKN2A mutations and multiple cases of cutaneous melanoma. We modeled penetrance for melanoma using a logistic regression model incorporating survival analysis. Hypothesis testing was based on likelihood ratio tests. Covariates included gender, alterations in p14ARF protein, and population melanoma incidence rates. All statistical tests were two-sided. Results: The 80 analyzed families contained 402 melanoma patients, 320 of whom were tested for mutations and 291 were mutation carriers. We also tested 713 unaffected family members for mutations and 194 were carriers. Overall, CDKN2A mutation penetrance was estimated to be 0.30 (95% confidence interval (CI) = 0.12 to 0.62) by age 50 years and 0.67 (95% CI = 0.31 to 0.96) by age 80 years. Penetrance was not statistically significantly modified by gender or by whether the CDKN2A mutation altered p14ARF protein. However, there was a statistically significant effect of residing in a location with a high population incidence rate of melanoma (P = .003). By age 50 years CDKN2A mutation penetrance reached 0.13 in Europe, 0.50 in the United States, and 0.32 in Australia; by age 80 years it was 0.58 in Europe, 0.76 in the United States, and 0.91 in Australia. Conclusions: This study, which gives the most informed estimates of CDKN2A mutation penetrance available, indicates that the penetrance varies with melanoma population incidence rates. Thus, the same factors that affect population incidence of melanoma may also mediate CDKN2A penetrance. [J Natl Cancer Inst 2002;94:894-903]

Published
2002

10. Dominant negative ATM mutations in breast cancer families

Author

Chenevix-Trench, Georgia, Spurdle, Amanda B., Gatei, Magtouf, Kelly, Helena, Marsh, Anna, Chen, Xiaoqing, Donn, Karen, Cummings, Margaret, Nyholt, Dale, Jenkins, Mark A., Scott, Clare, Pupo, Gulietta M., Dork, Thilo, Bendix, Regina, Kirk, Judy, Tucker, Katherine, McCredie, Margaret R.E., Hopper, John L., Sambrook, Joseph, Mann, Graham J., and Khanna, Kum Kum

Subjects
Gene mutations -- Physiological aspects, Breast cancer -- Genetic aspects, Health
Abstract

Background: The ATM gene encoding a putative protein kinase is mutated in ataxia-telangiectasia (A-T), an autosomal recessive disorder with a predisposition for cancer. Studies of A-T families suggest that female heterozygotes have an increased risk of breast cancer compared with non-carriers. However, neither linkage analyses nor mutation studies have provided supporting evidence for a role of ATM in breast cancer predisposition. Nevertheless, two recurrent ATM mutations, T7271G and IVS10-6T[right arrow]G, reportedly increase the risk of breast cancer. We examined these two ATM mutations in a population-based, case--control series of breast cancer families and multiple-case breast cancer families. Methods: Five hundred twenty-five or 262 case patients with breast cancer and 381 or 68 control subjects, respectively, were genotyped for the T7271G and IVS10-6T[right arrow]G ATM mutations, as were index patients from 76 non-BRCA1/2 multiple-case breast cancer families. Linkage and penetrance were analyzed. ATM protein expression and kinase activity were analyzed in lymphoblastoid cell lines from mutation carriers. All statistical tests were two-sided. Results: In case and control subjects unselected for family history of breast cancer, one case patient had the T7271G mutation, and none had the IVS10-6T [right arrow]G mutation. In three multiple-case families, one of these two mutations segregated with breast cancer. The estimated average penetrance of the mutations was 60% (95% confidence interval [CI] = 32% to 90%) to age 70 years, equivalent to a 15.7-fold (95% CI = 6.4-fold to 38.0-fold) increased relative risk compared with that of the general population. Expression and activity analyses of ATM in heterozygous cell lines indicated that both mutations are dominant negative. Conclusion: At least two ATM mutations are associated with a sufficiently high risk of breast cancer to be found in multiple-case breast cancer families. Full mutation analysis of the ATM gene in such families could help clarify the role of ATM in breast cancer susceptibility. [J Natl Cancer Inst 2002;94:205-15]

Published
2002

11. Prevalence and predictors of germline CDKN2A mutations for melanoma cases from Australia, Spain and the United Kingdom

Author

Harland, Mark, Cust, Anne E, Badenas, Celia, Chang, Yu-Mei, Holland, Elizabeth A, Aguilera, Paula, Aitken, Joanne F, Armstrong, Bruce K, Barrett, Jennifer H, Carrera, Cristina, Chan, May, Gascoyne, Joanne, Giles, Graham G, Agha-Hamilton, Chantelle, Hopper, John L, Jenkins, Mark A, Kanetsky, Peter A, Kefford, Richard F, Kolm, Isabel, Lowery, Johanna, Malvehy, Josep, Ogbah, Zighereda, Puig-Butille, Joan-Anton, Orihuela-Segalñs, Jordi, Randerson-Moor, Juliette A, Schmid, Helen, Taylor, Claire F, Whitaker, Linda, Bishop, D Timothy, Mann, Graham J, Newton-Bishop, Julia A, and Puig, Susana

Subjects
Company distribution practices, Health
Abstract

Background Mutations in the CDKN2A and CDK4 genes predispose to melanoma. From three case-control studies of cutaneous melanoma, we estimated the prevalence and predictors of these mutations for people from regions with widely differing latitudes and melanoma incidence. Methods Population-based cases and controls from the United Kingdom (1586 cases, 499 controls) and Australia (596 early-onset cases, 476 controls), and a hospital-based series from Spain (747 cases, 109 controls), were screened for variants in all exons of CDKN2A and the p16INK4A binding domain of CDK4. Results The prevalence of mutations for people with melanoma was similar across regions: 2.3%, 2.5% and 2.0% for Australia, Spain and the United Kingdom respectively. The strongest predictors of carrying a mutation were having multiple primaries (odds ratio (OR) = 5.4, 95% confidence interval (CI: 2.5, 11.6) for 2 primaries and OR = 32.4 (95% CI: 14.7, 71.2) for 3 or more compared with 1 primary only); and family history (OR = 3.8; 95% CI:1.89, 7.5) for 1 affected first- or second-degree relative and OR = 23.2 (95% CI: 11.3, 47.6) for 2 or more compared with no affected relatives). Only 1.1% of melanoma cases with neither a family history nor multiple primaries had mutations. Conclusions There is a low probability ( Keywords: Family history, Multiple primaries, Population-based, Melanoma, CDKN2A, Author(s): Mark Harland[sup.1] , Anne E Cust[sup.2] , Celia Badenas[sup.3,4] , Yu-Mei Chang[sup.1] , Elizabeth A Holland[sup.5] , Paula Aguilera[sup.3,4] , Joanne F Aitken[sup.6] , Bruce K Armstrong[sup.2] , Jennifer [...]

Published
2014
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12. Labour Leave MPs seek answers from Tory leadership candidates on workers' rights, immigration, EU nationals in the UK, the NHS, and the economy

Subjects
Economic conditions -- Economic aspects -- Political aspects, Employee rights -- Economic aspects -- Political aspects, Emigration and immigration -- Economic aspects -- Political aspects, Workers -- Political activity -- Economic aspects -- Political aspects, Prime ministers -- Political activity -- Economic aspects -- Political aspects, Immigration policy -- Economic aspects -- Political aspects, Business, international
Abstract

London: Frank Field MP has issued the following news release: Labour MPs Frank Field, Kate Hoey, John Mann, Graham Stringer, and Gisela Stuart - each of whom campaigned for the [...]

Published
2016

13. Stewart Mortgage Information Announces Alliance With Texas Law Firm

Subjects
Stewart Information Services Corp., Insurance industry, Insurance industry, Business, News, opinion and commentary
Abstract

Stewart Mortgage Information (SMI), a wholly owned subsidiary of Stewart Information Services Corp. , has announced an alliance with Black, Mann & Graham, L.L.P., to provide post closing services to [...]

Published
2002

14. The nominees

Subjects
Academy Awards, Motion picture industry -- Achievements and awards, Arts and entertainment industries, Business
Abstract

PICTURE 'The Aviator'--Michael Mann, Graham King, producers (Miramax, Initial Entertainment Group and Warner Bros.) 'Finding Neverland'--Richard N. Gladstein, Nellie Bellflower, producers; a FilrnColony production (Miramax) 'Million Dollar Baby'--Clint Eastwood, Albert [...]

Published
2005

15. The nominees

Subjects
Academy Awards -- 2005 AD, Motion picture industry -- Achievements and awards, Arts and entertainment industries, Business, Achievements and awards
Abstract

PICTURE 'The Aviator'--Michael Mann, Graham King, producers (Miramax, Initial Entertainment Group and Warner Bros.) 'Finding Neverland'--Richard N. Gladstein, Nellie Bellflower, producers; a FilmColony production (Miramax) 'Million Dollar Baby'--Clint Eastwood, Albert [...]

Published
2005

16. Economic Growth Trajectory In International Business: Explorative Case Analysis On The Attractiveness Of Sub-Saharan Africa's Consumer And Business Markets

Author

Mboga, Jet and Ammar, Sonia

Subjects
Sub-Saharan Africa -- International economic relations -- Statistics, Economic growth -- Statistics -- Forecasts and trends -- International aspects, Consumers -- Target marketing -- International aspects, Market trend/market analysis, Review of past year, World market, Business, general, Business
Abstract

The African continent is projected to increase population over the coming years. Sub-Saharan Africa accounts for the highest population growth projections and the most populous organizations that seek outsourcing. We explored whether three sub- Saharan African countries with U.N. growth projections as potential outsourcing destinations, and set out to identify what these countries could do to attract companies. We found that the limited support for growing organizations, such as electronics, is connected to having a limited skilled workforce in I.T. to support the growing organization's needs. To attain a suitable business environment and attract outsourcing clients and investors from other countries, African governments should take the initiative to improve their nations' specialized training and infrastructure., Introduction The African continent is projected to increase population over the coming years, with 2.5 billion people by 2050 and 4.5 billion people by 2100 (Goldstone, 2019; Suzuki, 2019; U.N. [...]

Published
2022

17. Books

Subjects
United Kingdom, Ardley, Neil Richard, Ellington, Duke
Abstract

Kansas City Jazz Con Chapman Equinox HB £40.00 Novelist/playwright Con Chapman’s initial foray into the world of jazz literature came with Rabbit’s Blues, his well-received biography of Duke Ellington’s star [...]

Published
2023

18. Irish drop opening series, rebound with sweep at No. 3 Michigan

Author

Gibson, Dominic

Subjects
News, opinion and commentary, Sports and fitness, University of Michigan. Athletics. Wolverines
Abstract

Byline: Dominic Gibson The Notre Dame hockey team kicked off its 2020-21 season with a two-game series against the Wisconsin Badgers at home at the Compton Family Ice Arena on [...]

Published
2020

19. Brexit: All 29 Tory rebels who voted to seize control from Theresa May; The Prime Minister hasn't just lost control of Brexit. She's lost control of the Conservative Party too. Here are all 29 rebels

Subjects
Political parties, Brexit -- Political aspects, Prime ministers -- Political activity -- Political aspects, Ministers (Clergy), General interest, News, opinion and commentary
Abstract

Byline: Dan Bloom Theresa May didn't justlose control of Brexit last night- she lost control of the Conservative party. An astonishing 29 of her own Tory MPs rebelled against her [...]

Published
2019

22. Reports Outline Transcription Factors Findings from Newcastle University (Crel Expression Regulates Distinct Transcriptional and Functional Profiles Driving Fibroblast Matrix Production In Systemic Sclerosis)

Subjects
Systemic scleroderma -- Genetic aspects, Medical research -- Physiological aspects, Medicine, Experimental -- Physiological aspects, Genetic research -- Physiological aspects -- Genetic aspects, Scleroderma (Disease) -- Genetic aspects, DNA binding proteins -- Physiological aspects -- Genetic aspects, Health
Abstract

2021 FEB 19 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators discuss new findings in Proteins - Transcription Factors. According to news reporting [...]

Published
2021

23. Frank Field criticises local Labour members after losing confidence vote; Brexiter's constituency passed vote against him after similar motion against Kate Hoey

Subjects
Political parties -- United Kingdom, Brexit -- Political aspects, No confidence motions -- Political aspects, News, opinion and commentary
Abstract

Byline: Patrick Greenfield Frank Field has criticised local Labour party members after he became the latest party MP to lose a confidence vote for siding with the government in key [...]

Published
2018

24. III. Collaboration in Health Care

Author

Ellingson, Laura L.

Subjects
Communication in medicine -- Management -- Research, Medical personnel -- Behavior, Company business management, Sociology and social work
Abstract

Some level of collaboration between health care providers is necessary in any health care setting. In hospitals, careful coordination of services between nurses, nursing assistants, physicians, and a variety of [...]

Published
2002

25. Johnson Launches Brexit Attack on British Premier, May Slaps Him Down

Subjects
Political parties -- United Kingdom, Foreign ministers, Brexit, Prime ministers, Business, international
Abstract

Theresa May today slapped down Boris Johnson after he made an audacious pitch for her job in a fiery resignation speech in the Commons. The former Foreign Secretary launched an [...]

Published
2018

26. Theresa May could be left reliant on the enemy to defeat Brexit amendments

Subjects
Brexit, General interest, News, opinion and commentary, European Union
Abstract

Byline: Edward Malnick, Whitehall Editor This week Theresa May faces arguably her biggest challenge yet, as she attempts to dismantle or water down 14 House of Lords amendments to the [...]

Published
2018

27. Northstar Buys Controlling Stake in Goldome

Subjects
Banking industry -- Mergers, acquisitions and divestments, Company acquisition/merger, Banking industry, Banking, finance and accounting industries, Business, Real estate industry
Abstract

Byline: Brad Finkelstein Northstar Bank of Texas, Denton, Texas, has acquired the controlling interest in Goldome Financial Inc., a mortgage warehouse lender based in Flower Mound, Texas. Terms of the [...]

Published
2013

28. Carlile Buys Texas Warehouse Lender

Author

Witkowski, Rachel

Subjects
Mortgage banks -- Mergers, acquisitions and divestments, Banking industry -- Mergers, acquisitions and divestments, Company acquisition/merger, Banking industry, Banking, finance and accounting industries, Business, Economics
Abstract

Byline: Rachel Witkowski Carlile Bancshares in Fort Worth, Texas, has completed its second acquisition in as many weeks. Carlile's Northstar Bank of Texas in Denton said Monday that it had [...]

Published
2013

29. Reporting Backs Vendor Hype

Subjects
Banking, finance and accounting industries, Business
Abstract

How do lenders get past a vendors sales pitch and get them to prove their claims? In an attempt to solve this issue, Guardian Mortgage Documents has released Client Performance [...]

Published
2007

32. Work continues on SUNY Buffalo Law School

Subjects
Law schools, Displays (Marketing), General interest, News, opinion and commentary
Abstract

Byline: Denise M. Champagne The first floor renovation of the SUNY Buffalo Law School is complete. The centerpiece of the project is the new lobby in John Lord O'Brian Hall, [...]

Published
2012

33. G2: 'Gizza job, CBeebies': He is best known for playing violent thugs in This Is England, Occupation and now Michael Mann's Public Enemies. But actor Stephen Graham has other ambitions, discovers Patrick Barkham

Subjects
This Is England (Motion picture), Actors, Actresses, News, opinion and commentary
Abstract

Byline: Patrick Barkham A psychopathic Chicago gangster. A violent racist. A murderous mobster. A prostitute user. An avaricious, adrenalin-addicted mercenary. A football hooligan. An alcoholic. Stephen Graham has put his [...]

Published
2009

34. Five to be honored at annual University at Buffalo Law School dinner

Subjects
Law schools, Associations, institutions, etc., Societies, General interest, News, opinion and commentary
Abstract

Five graduates of the University at Buffalo Law School and Interim Dean Makau Mutua, a non-alumnus, will receive Distinguished Alumni Awards for their contributions to the legal profession and community [...]

Published
2008

35. Engineers will need to use sound judgment

Author

Rodman, Sarah

Abstract

Byline: SARAH RODMAN In all the hoopla surrounding Bruce Springsteen's concerts at Fenway Park, one question has been bubbling around with the fans: How's it going to sound? Fan Rahul […]

Published
2003

36. Northstar Acquires Mortgage Warehouse Company

Subjects
Company acquisition/merger, Business, News, opinion and commentary
Abstract

DENTON, Texas, Dec. 31, 2012 /PRNewswire/ -- Northstar Bank of Texas ('Northstar'), a state chartered banking association headquartered in Denton, Texas, a member of Carlile Bancshares, Inc. ('Carlile'), a bank [...]

Published
2012

37. SAT, conference swimming finals converge, conflict; BY; ANDREW BELL

Subjects
General interest, News, opinion and commentary
Abstract

Stymied may be a good 'SAT word' to describe the effects the test will have on today's Western Conference Finals and Division Championships. Seniors who chose to take SAT's today [...]

Published
2000

38. Byte Software Adds Seven Service Providers in 2011 with More to Follow

Subjects
Computer software industry, Financial software, Software, Banking/finance/investment software, Software quality, Business, general
Abstract

Kirkland, WA (PRWEB) September 27, 2011 Byte Software announces that it has added seven new service providers to its BytePro loan origination software system. Byte Software provides end-to-end mortgage software [...]

Published
2011

39. DIXIE CLASSIC FAIR WINNERS

Subjects
General interest, News, opinion and commentary
Abstract

These people won awards at the Dixie Classic Fair: Open Dairy Goat Show Toggenburg: Grand Champion Doe & Reserve Grand Champion Doe: Bruce Smith, Dobson; Grand Champion; Bruce Smith, Dobson; [...]

Published
1999

40. New Mortgage Service Provider Added to Calyx Software Network

Subjects
Calyx Software, Computer software industry, Software, Mortgages, Software quality, Mortgages, Business, Business, international
Abstract

Interface Update Expands Connections to Mortgage Service Providers SAN JOSE, Calif. -- Calyx Software([R]), the mortgage industry's leading provider of loan marketing, originating and processing software, has expanded The Calyx [...]

Published
2009

41. DIXIE CLASSIC FAIR WINNERS

Subjects
General interest, News, opinion and commentary
Abstract

These people won first-place awards at the Dixie Classic Fair: Beef Cattle Angus: Jr. Heif Calf.-01/01/98 & Aft., MEGAN BIRDSELL, Crumpler; Angus - Jr. Heifer Calf Champion, MEGAN BIRDSELL, Crumpler; [...]

Published
1998

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