1. A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer
- Author
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Ng, King Pan, Hillmer, Axel M., Chuah, Charles T.H., Juan, Wen Chun, Ko, Tun Kiat, Teo, Audrey S.M., Ariyaratne, Pramila N., Takahashi, Naoto, Sawada, Kenichi, Fei, Yao, Soh, Sheila, Lee, Wah Heng, Huang, John W.J., Allen, Jr., John C., Woo, Xing Yi, Nagarajan, Niranjan, Kumar, Vikrant, Thalamuthu, Anbupalam, Poh, Wan Ting, Ang, Ai Leen, Mya, Hae Tha, How, Gee Fung, Yang, Li Yi, Koh, Liang Piu, Chowbay, Balram, Chang, Chia-Tien, Nadarajan, Veera S., Chng, Wee Joo, Than, Hein, Lim, Lay Cheng, Goh, Yeow Tee, Zhang, Shenli, Poh, Dianne, Tan, Patrick, Seet, Ju-Ee, Ang, Mei-Kim, Chau, Noan-Minh, Ng, Quan-Sing, Tan, Daniel S.W., Soda, Manabu, Isobe, Kazutoshi, Nothen, Markus M., Wong, Tien Y., Shahab, Atif, Ruan, Xiaoan, Cacheux-Rataboul, Valere, Sung, Wing-Kin, Tan, Eng Huat, Yatabe, Yasushi, Mano, Hiroyuki, Soo, Ross A., Chin, Tan Min, Lim, Wan-Teck, Ruan, Yijun, and Ong, S. Tiong
- Subjects
Physiological aspects ,Genetic aspects ,Research ,Dosage and administration ,Protein-tyrosine kinase -- Physiological aspects -- Genetic aspects -- Research ,Tumor proteins -- Physiological aspects -- Genetic aspects -- Research ,Genetic polymorphisms -- Physiological aspects -- Research -- Genetic aspects ,Antineoplastic agents -- Dosage and administration -- Genetic aspects -- Research ,Protein tyrosine kinase -- Physiological aspects -- Genetic aspects -- Research ,Antimitotic agents -- Dosage and administration -- Genetic aspects -- Research - Abstract
Tyrosine kinase inhibitors (TKIs) elicit high response rates among individuals with kinase-driven malignancies, including chronic myeloid leukemia (CML) and epidermal growth factor receptor-mutated non-small-cell lung cancer (EGFR NSCLC). However, the [...]
- Published
- 2012
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