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Context.--Ocular surface squamous neoplasia (OSSN) is the most common tumor of conjunctival epithelium associated with risk of permanent visual impairment. It includes conjunctival intraepithelial neoplasia and squamous cell carcinoma. Although American Joint Committee on Cancer-TNM (AJCC-TNM) staging is commonly used in various tumors, it has only recently been described for OSSN. Objectives.--To evaluate the prognostic relevance of AJCC-TNM staging and the clinicopathological features in OSSN. Design.--Sixty-four histopathologically proven cases of OSSN (20 conjunctival intraepithelial neoplasia and 44 squamous cell carcinoma) were included in the study. The AJCC-TNM staging and clinicopathological features of OSSN cases were recorded. Patients were followed up for 17 to 40 months (median, 32 months). Univariate and multivariate analyses were performed to determine the prognostic value of various clinicopathological features. Results.--Longer sunlight exposure (P = .01), diffuse growth pattern (P = .02), larger tumor size ([greater than or equal to]2 cm) (P = .03), histopathological diagnosis of squamous cell carcinoma (P = .02), and orbital invasion or invasion of adjacent structures (T3 or T4) (P < .001) emerged as significant predictors of reduced recurrence-free survival. Using multivariate analysis, a higher T category (T3 or T4) was the most important prognostic indicator of a poor outcome. Conclusions.--A higher T category (T3 or T4) is an important predictor of clinical outcome, and the use of the AJCC-TNM staging system is recommended in the management of all patients with OSSN. Longer sunlight exposure, larger tumor size ([greater than or equal to]2 cm), orbital invasion or invasion of adjacent structures (T3 or T4), and a histopathological diagnosis of squamous cell carcinoma are other clinicopathological features of prognostic relevance in patients with OSSN. (Arch Pathol Lab Med. 2014; 138:1488-1494; doi: 10.5858/arpa.2013-0353-OA), Ocular surface squamous neoplasia (OSSN) is the most common tumor of the ocular surface, with an estimated incidence of 0.02 to 3.5 cases per 100 000 worldwide. (1) It represents [...]

Byline: Puja. Sahai, Karuna. Singh, Seema. Sharma, Seema. Kashyap, Bidhu. Mohanti Sir, Xeroderma pigmentosum (XP) is a rare autosomal recessive inherited disease. It is characterized by defective nucleotide excision repair [...]

* Context.--In eyes enucleated for retinoblastoma, presence of histopathologic high-risk factors is associated with a higher risk of local recurrence and systemic metastasis. Objective.--To evaluate histopathologic features in children with retinoblastoma in our population and establish relationship between age, tumor differentiation, and high-risk features. Design.--Retrospective histopathologic analysis of 609 consecutively enucleated eyes for advanced intraocular retinoblastoma during a 10-year period. A nonparametric test was used to establish relationship between age, differentiation, and high-risk features. Results.--Poorly differentiated retinoblastoma presented in 80.3% and well-differentiated in 19.7% of eyes. Well differentiated tumors presented earlier (median 1.2 years) than poorly differentiated tumors (median 2.5 years) (P < .001). One hundred fourteen eyes (18.7%) had 1 and 138 (22.7%) had at least 2 high-risk histopathologic factors. Invasion of anterior chamber was found in 10.0%, iris in 10.7%, ciliary body in 6.7%, sclera in 13.7%, massive choroid in 24.6%, postlaminar optic nerve in 16.1%, resected margin of the optic nerve in 7.4%, and extrascleral tissue in 4.1% of eyes. Extensive necrosis was seen in 31.0% of eyes. Poorly differentiated tumors were significantly associated with presence of more than 1 high-risk histopathologic feature (P < .001) and extensive necrosis (P < .001). Conclusion.--Poorly differentiated tumors present at a later ageandareassociatedwith presence of multiple high-risk factors and extensive necrosis. In our population, high-risk histopathologic factors are present in a significant number of eyes. Because we have included only primarily enucleated eyes, this could truly represent the distribution of high-risk histopathologic factors in children with retinoblastoma. (Arch Pathol Lab Med. 2012; 136:190-193; doi: 10.5858/arpa.2010-0759-OA), Retinoblastoma is the most frequent primary malignant intraocular tumor in children and has an estimated annual incidence of 1 in 16000 to 1 in 18000 live births.1 With the present-day [...]