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4 results on '"Kaban, Leonard B"'

1. Temporomandibular disorders

Author

Scrivani, Steven J., Keith, David A., and Kaban, Leonard B.

Subjects
Temporomandibular joint disorders -- Research, Temporomandibular joint disorders -- Causes of
Abstract

The afflictions due to the inflammation of the temporomandibular joint (TMJ) among women are highlighted. Temporomandibular disorders are associated with craniofacial pain problems in the musculoskeletal structures of the head and neck.

Published
2008

3. Antiangiogenic Therapy of a Recurrent Giant Cell Tumor of the Mandible With Interferon Alfa-2a

Author

Kaban, Leonard B., Mulliken, John B., Ezekowitz, R. Alan, Phil, D, Ebb, David, Smith, Peter S., and Folkman, Judah

Subjects
Giant cell tumors -- Drug therapy, Interferon alpha -- Health aspects, Head and neck tumors -- Drug therapy, Tumors in children -- Drug therapy
Abstract

Interferon alfa-2a was used successfully to treat a recurrent giant cell tumor of the mandible in a 5-year-old girl. The child developed a rapidly growing tumor of the jaw that was surgically removed twice, but continued to grow. Interferon alfa-2a inhibits the development of new blood vessels, and has been used in vascular tumors. Doctors began treating the child with interferon, desiring to avoid disfiguring surgery and radiation therapy. Progressively higher doses of interferon effectively eradicated the tumor, and the child remained free of the tumor three years after therapy was terminated., We report a 5-year-old girl with a large rapidly growing giant cell tumor of the mandible that recurred 2 months after the first surgical excision and 3 months after a second resection. An angiogenic protein, (bFGF), was abnormally elevated in her urine. The patient was treated with interferon alfa-2a for 1 year because this agent inhibits angiogenesis by suppressing bFGF overexpression in infantile hemangiomas and in other human tumors. During this time the bone tumor regressed and disappeared, the urinary bFGF fell to normal levels, and the mandible regenerated. She has remained tumor-free and has been off therapy for 3 years at this writing. This first successful use of interferon alfa-2a to treat a mandibular tumor in a child demonstrates: 1) low grade tumors that overexpress bFGF may respond to interferon alfa-2a, in a manner similar to life-threatening infantile he mangiomas; 2) antiangiogenic therapy, given without interruption for 1 year, was safe and effective in this patient; and 3) treatment may be continued for 1 year without the development of drug resistance. Pediatrics 1979;103:1145-1149; interferon alfa-2a, basic fibroblast growth factor, angiogenesis, giant cell tumor of mandible., ABBREVIATIONS. bFGF, basic fibroblast growth factor; VEGF, vascular endothelial growth factor. Interferon alfa-2a was found to inhibit angiogenesis through a series of laboratory experiments that began in 1980.[1-3] In 1989, [...]

Published
1999

4. Temporomandibular joint: morphology and signal intensity characteristics of the disk at MR imaging

Author

Helms, Clyde A., Kaban, Leonard B., McNeill, Charles, and Dodson, Thomas

Subjects
Joints, Magnetic resonance imaging -- Usage, Jaws -- Abnormalities, Temporomandibular joint, Osteoarthritis -- Diagnosis, Health
Abstract

Magnetic resonance (MR) imaging is a useful technique for documenting internal derangement of the temporomandibular joint (TMJ, the joint of the jaw located in front of the ear). MR imaging reflects the location of the disk in the TMJ as well as the morphology and signal intensity characteristics of the disk. This report considers the alterations in disk morphology and signal intensity with regard to derangement of the TMJ. Researchers obtained MR images of the TMJ in 133 patients (216 joints with a history of derangement) noting the position, morphology, and signal intensity of the disk and the presence or absence of osteoarthritis of the joint (characterized by chronic inflammation, destruction of cartilage, overgrowth of bone and impaired function). The MR images of the TMJ disks were placed in three categories: normal, grade 1 (displaced with a normal shape), and grade 2 (displaced with an abnormal shape). Nineteen percent of the disks were considered normal; none showed osteoarthritis. Sixty-four percent of the disks were reported as grade 1 with 17 percent having osteoarthritis. Grade 2 disks represented only 17 percent of the imaged TMJ disks, but 95 percent of them showed osteoarthritis. TMJ joints with osteoarthritis exhibited diminished signal intensity, and osteoarthritis is a known complication of severe or untreated TMJ derangement. As the TMJ disk degenerates it loses its normal shape and becomes a mass of fibrous tissue. The grading system seems to accurately describe the clinical findings and correlate with the diagnoses. However, further evaluation of MR imaging of TMJ disk deformity is needed before this technique can achieve widespread clinical application.

Published
1989

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