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1. Diffusion-time distribution analysis reveals characteristic ligand-dependent interaction patterns of nuclear receptors in living cells

Author

Jankevics, Hanna, Prummer, Michael, Izewska, Paulina, Pick, Horst, Leufgen, Kirsten, and Vogel, Horst

Subjects
Ligand binding (Biochemistry) -- Research, Cell culture -- Research, Estrogen -- Receptors, Estrogen -- Chemical properties, Estrogen -- Structure, Biological sciences, Chemistry
Abstract

A study is conducted to show that the nuclear receptors initiate transcription, interacts with regulatory proteins, and are influenced by hormones, drugs and pollutants. The ligand-specific mobility patterns of human estrogen receptor-alpha (ER) in living cells are discussed using diffusion-time distribution analysis (DDA).

Published
2005

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