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Background: Only a few studies have been done involving detection of human papillomavirus (HPV) DNA on the external genitalia of men without genital warts, although many have been done for women. We conducted HPV DNA detection among healthy male volunteers and men with urethritis, both having no visible lesions on their external genitalia. Goal: The goal of the study was to determine the detection rate of HPV DNA in volunteers and patients with urethritis and to determine risk factor(s) for positive DNA. Study Design: This was a prospective clinical study. Results: HVP DNA was found in 1.3% of 75 volunteers and in 18.5% of 130 patients with urethritis. DNA of a high-intermediate oncogenic risk was more predominant than the low-risk type. Among various risk factors, only a history of STD was a significant factor for the positive detection of HPV DNA in multiple regression analysis. Conclusion: HPV DNA was found in patients with uretbritis more frequently than in volunteers, probably because the former had higher sexual activity.

Background and Objectives: Because warts are often found in the male urethra, human papillomavirus (HPV) may well be present in urine of patients with urethral condylomata. Goal: To detect HPV DNA in urine specimens of men with condylomata acuminate using polymerase chain reaction. Study Design: Forty-seven urine specimens and 25 paraffin-embedded tissues of condylomata acuminate were obtained from men. Of the 47 urine specimens, 29 were from patients with urethral condylomata, 3 from patients with penile condylomata only, and 15 from control subjects without condylomata. Both L1 consensus primers and type-specific primers for HPV 6, 11, 16, 18, and 33 were used. Results: HPV DNA was detected in 22 of the 29 (76%) urine specimens from patients with urethral condylomata, in none of the 3 urine specimens from patients with penile condylomata, and in none of the 15 controls. Paraffin-embedded tissues of all 25 condylomas were positive for HPV DNA. The HPV types detected in urine were identical to those detected in urethral condylomas. Conclusions: HPV DNA is present in urine of patients with urethral condylomata. Urine may be used for noninvasive screening of asymptomatic HPV infections of the male genital tract. Detection of HPV DNA in urine may be useful for monitoring the response to treatment of urethral condylomata., Urine tests appear to be an effective way to screen for and monitor patients with human papillomavirus (HPV) or urethral condylomata. Urine samples from 29 patients with urethral condylomata, 3 patients with penile condylomata, and 15 healthy volunteers were tested for the presence of various strains of HPV. Tissue samples from 25 patients with condylomata were also tested for HPV. Seventy-six percent of the urine samples from patients with urethral condylomata were positive for HPV. Urine samples from none of the other participants were positive for HPV. All of the tissue samples were positive for HPV.