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Your search keyword '"Issifou, Saadou"' showing total 18 results
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18 results on '"Issifou, Saadou"'

1. Placental malaria increases malaria risk in the first 30 months of life

Author

Schwarz, Norbert G., Adegnika, Ayola A., Breitling, Lutz P., Gabor, Julian, Agnandji, Selidji T., Newman, Robert D., Lell, Bertrand, Issifou, Saadou, Yazdanbakhsh, Maria, Luty, Adrian J.F., Kremsner, Peter G., and Grobusch, Martin P.

Subjects
Malaria -- Risk factors, Perinatal infection -- Research, Health, Health care industry
Published
2008

2. Artesunate-clindamycin versus quinine-clindamycin in the treatment of Plasmodium falciparum malaria: a randomized controlled trial

Author

Ramharter, Michael, Oyakhirome, Sunny, Klouwenberg, Peter Klein, Adegnika, Ayola A., Agnandji, Selidji T., Missinou, Michel A., Matsiegui, Pierre-Blaise, Mordmuller, Benjamin, Borrmann, Steffen, Kun, Jurgen F., Lell, Bertrand, Krishna, Sanjeev, Graninger, Wolfgang, Issifou, Saadou, and Kremsner, Peter G.

Subjects
Quinine -- Dosage and administration, Malaria -- Drug therapy, Clindamycin -- Dosage and administration, Health, Health care industry
Published
2005

4. Evaluation of the safety and immunogenicity of the RTS,S/AS01E malaria candidate vaccine when integrated in the expanded program of immunization

Author

Agnandji, Selidji T., Asante, Kwaku Poku, Lyimo, John, Vekemans, Johan, Soulanoudjingar, Solange S., Owusu, Ruth, Shomari, Mwanajaa, Leach, Amanda, Fernandes, Jose, Dosoo, David, Chikawe, Maria, Issifou, Saadou, Osei-Kwakye, Kingsley, Lievens, Marc, Paricek, Maria, Apanga, Stephen, Mwangoka, Grace, Okissi, Blaise, Kwara, Evans, Minja, Rose, Lange, Jorn, Boahen, Owusu, Kayan, Kingsley, Adjei, George, Chandramohan, Daniel, Jongert, Erik, Demoitie, Marie-Ange, Dubois, Marie-Claude, Carter, Terrel, Vansadia, Preeti, Villafana, Tonya, Sillman, Marla, Savarese, Barbara, Lapierre, Didier, Ballou, William Ripley, Greenwood, Brian, Tanner, Marcel, Cohen, Joe, Kremsner, Peter G., Lell, Bertrand, Owusu-Agyei, Seth, and Abdulla, Salim

Subjects
Immunization -- Usage, Immunization -- Health aspects, Malaria -- Prevention, Malaria vaccine -- Usage, Malaria vaccine -- Health aspects, Malaria vaccine -- Safety and security measures, Health
Published
2010

5. Endoglin in African children with Plasmodium falciparum malaria: a novel player in severe malaria pathogenesis?

Author

Dietmann, Anelia, Helbok, Raimund, Lackner, Peter, Fischer, Marlene, Reindl, Markus, Lell, Bertrand, Issifou, Saadou, Kremsner, Peter G., and Schmutzhard, Erich

Subjects
Membrane proteins -- Physiological aspects, Membrane proteins -- Demographic aspects, Membrane proteins -- Research, Malaria -- Development and progression, Malaria -- Demographic aspects, Malaria -- Research, Health
Published
2009

6. The Lambarene Organ Dysfunction Score (LODS) is a simple clinical predictor of fatal malaria in African children

Author

Helbok, Raimund, Kendjo, Eric, Issifou, Saadou, Lackner, Peter, Newton, Charles R., Kombila, Maryvonne, Agbenyega, Tsiri, Bojang, Kalifa, Dietz, Klaus, Schmutzhard, Erich, and Kremsner, Peter Gottfried

Subjects
Malaria -- Diagnosis, Malaria -- Demographic aspects, Malaria -- Research, Health risk assessment -- Methods, Health risk assessment -- Usage, Health risk assessment -- Research, Health
Published
2009

7. No rebound of morbidity following intermittent preventive sulfadoxine-pyrimethamine treatment of malaria in infants in Gabon

Author

Grobusch, Martin P., Gabor, Julian J., Aponte, John J., Schwarz, Norbert G., Poetschke, Marc, Doernemann, Jenny, Schuster, Katharina, Koester, Kai B., Profanter, Katharina, Borchert, Lea B., Kurth, Florian, Pongratz, Peter, Issifou, Saadou, Lell, Bertrand, and Kremsner, Peter G.

Subjects
Malaria -- Care and treatment, Malaria -- Prevention, Malaria -- Demographic aspects, Malaria -- Research, Antimalarials -- Dosage and administration, Antimalarials -- Complications and side effects, Antimalarials -- Research, Pyrimethamine -- Dosage and administration, Pyrimethamine -- Research, Morbidity -- Demographic aspects, Morbidity -- Research, Health
Published
2009

8. Prognostic value of circulating pigmented cells in African children with malaria

Author

Kremsner, Peter Gottfried, Valim, Clarissa, Missinou, Michel A., Olola, Christopher, Krishna, Sanjeev, Issifou, Saadou, Kombila, Maryvonne, Bwanaisa, Lloyd, Mithwani, Sadik, Newton, Charles R., Agbenyega, Tsiri, Pinder, Margaret, Bojang, Kalifa, Wypij, David, and Taylor, Terrie

Subjects
Malaria -- Demographic aspects, Malaria -- Patient outcomes, Malaria -- Physiological aspects, Malaria -- Research, Health
Published
2009

9. Intramuscular artesunate for severe malaria in African children: a multicenter randomized controlled trial

Author

Kremsner, Peter G., Adegnika, Akim A., Hounkpatin, Aurore B., Zinsou, Jeannot F., Taylor, Terrie E., Chimalizeni, Yamikani, Liomba, Alice, Kombila, Maryvonne, Bouyou-Akotet, Marielle K., Mboumba, Denise P. Mawili, Agbenyega, Tsiri, Ansong, Daniel, Sylverken, Justice, Ogutu, Bernhards R., Otieno, Godfrey A., Wangwe, Anne, Bojang, Kalifa A., Okomo, Uduak, Sanya- Isijola, Frank, Newton, Charles R., Njuguna, Patricia, Kazungu, Michael, Kerb, Reinhold, Geditz, Mirjam, Schwab, Matthias, Velavan, Thirumalaisamy P., Nguetse, Christian, Kohler, Carsten, Issifou, Saadou, Bolte, Stefanie, Engleitner, Thomas, Mordmuller, Benjamin, and Krishna, Sanjeev

Subjects
Children -- Diseases, Malaria -- Drug therapy, Biological sciences
Abstract

Background Current artesunate (ARS) regimens for severe malaria are complex. Once daily intramuscular (i.m.) injection for 3 d would be simpler and more appropriate for remote health facilities than the current WHO-recommended regimen of five intravenous (i.v.) or i.m. injections over 4 d. We compared both a three-dose i.m. and a three-dose i.v. parenteral ARS regimen with the standard five-dose regimen using a non-inferiority design (with non-inferiority margins of 10%). Methods and Findings This randomized controlled trial included children (0.5-10 y) with severe malaria at seven sites in five African countries to assess whether the efficacy of simplified three-dose regimens is non-inferior to a five-dose regimen. We randomly allocated 1,047 children to receive a total dose of 12 mg/kg ARS as either a control regimen of five i.m. injections of 2.4 mg/kg (at 0,12, 24, 48, and 72 h) (n = 348) or three injections of 4 mg/kg (at 0,24, and 48 h) either i.m. (n = 348) or i.v. (n = 351), both of which were the intervention arms. The primary endpoint was the proportion of children with >99% reduction in parasitemia at 24 h from admission values, measured by microscopists who were blinded to the group allocations. Primary analysis was performed on the per-protocol population, which was 96% of the intention-to-treat population. Secondary analyses included an analysis of host and parasite genotypes as risks for prolongation of parasite clearance kinetics, measured every 6 h, and a Kaplan-Meier analysis to compare parasite clearance kinetics between treatment groups. A post hoc analysis was performed for delayed anemia, defined as hemoglobin ≤ 7g/dl 7 d or more after admission. The per-protocol population was 1,002 children (five-dose i.m.: n = 331; three-dose i.m.: n = 338; three-dose i.v.: n = 333); 139 participants were lost to follow-up. In the three-dose i. m. arm, 265/338 (78%) children had a >99% reduction in parasitemia at 24 h compared to 263/331 (79%) receiving the five-dose i.m. regimen, showing non-inferiority of the simplified three-dose regimen to the conventional five-dose regimen (95% CI -7,5; p = 0.02). In the three-dose i.v. arm, 246/333 (74%) children had ≥ 99% reduction in parasitemia at 24 h; hence, non-inferiority of this regimen to the five-dose control regimen was not shown (95% CI -12,1; p = 0.24). Delayed parasite clearance was associated with the [sup.N86Y]Pfmdr1 genotype. In a post hoc analysis, 192/885 (22%) children developed delayed anemia, an adverse event associated with increased leukocyte counts. There was no observed difference in delayed anemia between treatment arms. A potential limitation of the study is its open-label design, although the primary outcome measures were assessed in a blinded manner. Conclusions A simplified three-dose i.m. regimen for severe malaria in African children is non-inferior to the more complex WHO-recommended regimen. Parenteral ARS is associated with a risk of delayed anemia in African children. Trial registration Pan African Clinical Trials Registry PACTR201102000277177, Introduction Studies to optimize artesunate (ARS) treatment regimens in malaria have been surprisingly sparse, given that ARS is now established as the treatment of choice for severe malaria in both [...]

Published
2016
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10. Pregnancy-associated malaria affects toll-like receptor ligand-induced cytokine responses in cord blood

Author

Adegnika, Ayola A., Kohler, Carsten, Agnandji, Selidji T., Chai, Sanders K., Labuda, Lucja, Breitling, Lutz P., Schonkeren, Dorrith, Weerdenburg, Eveline, Issifou, Saadou, Luty, Adrian J.F., Kremsner, Peter G., and Yazdanbakhsh, Maria

Subjects
Perinatal infection -- Research, Malaria -- Development and progression, Malaria -- Research, Cytokines -- Physiological aspects, Cytokines -- Research, Immune response -- Research, Health
Published
2008

11. Fixed-dose pyronaridine-artesunate combination for treatment of uncomplicated falciparum malaria in pediatric patients in Gabon

Author

Ramharter, Michael, Kurth, Florian, Schreier, Annette C., Nemeth, Johannes, von Glasenapp, Isabelle, Belard, Sabine, Schlie, Meike, Kammer, Judith, Koumba, Philemon Koumba, Cisse, Badara, Mordmuller, Benjamin, Lell, Bertrand, Issifou, Saadou, Oeuvray, Claude, Fleckenstein, Lawrence, and Kremsner, Peter G.

Subjects
Antimalarials -- Dosage and administration, Antimalarials -- Research, Drug therapy, Combination -- Demographic aspects, Drug therapy, Combination -- Research, Malaria -- Care and treatment, Children -- Diseases, Children -- Care and treatment, Health
Published
2008

13. Intermittent preventive treatment against malaria in infants in Gabon - a randomized, double-blind, placebo-controlled trial

Author

Grobusch, Martin P., Lell, Bertrand, Schwarz, Norbert G., Gabor, Julian, Dornemann, Jenny, Potschke, Marc, Oyakhirome, Sunny, Kiessling, Georg C., Necek, Magdalena, Langin, Matthias U., Klein Klouwenberg, Peter, Klopfer, Anna, Naumann, Benjamin, Altun, Handan, Agnandji, Selidji T., Goesch, Julia, Decker, Marieluise, Ospina Salazar, Carmen L., Supan, Christian, Kombila, Davy U., Borchert, Lea, Koster, Kai B., Pongratz, Peter, Adegnika, Akim A., von Glasenapp, Isabelle, Issifou, Saadou, and Kremsner, Peter G.

Subjects
Infants -- Health aspects, Malaria -- Demographic aspects, Malaria -- Prevention, Experimental design -- Demographic aspects, Health
Published
2007

15. Clinical and parasitological characteristics of puerperal malaria

Author

Ramharter, Michael, Grobusch, Martin P., Kiessling, Georg, Adegnika, Ayola A., Moller, Ulrike, Agnandji, Selidji T.M., Kramer, Martin, Schwarz, Norbert, Kun, Jurgen F.J., Oyakhirome, Sunny, Issifou, Saadou, Borrmann, Steffen, Lell, Bertrand, Mordmuller, Benjamin, and Kremsner, Peter G.

Subjects
Malaria -- Risk factors, Malaria -- Development and progression, Puerperal disorders -- Research, Women -- Health aspects, Health
Published
2005

16. Fosmidomycin-clindamycin for the treatment of Plasmodium falciparum malaria

Author

Borrmann, Steffen, Issifou, Saadou, Esser, Gilbert, Adegnika, Ayola A., Ramharter, Michael, Matsiegui, Pierre-Blaise, Oyakhirome, Sunny, Mawili-Mboumba, Denise P., Missinou, Michel A., Kun, Jurgen F.J., Jomaa, Hassan, and Kremsner, Peter G.

Subjects
Plasmodium falciparum -- Drug therapy, Plasmodium falciparum -- Research, Clindamycin -- Dosage and administration, Clindamycin -- Research, Health
Published
2004

18. Fosmidomycin for malaria. (Research Letters)

Author

Missinou, Michel A, Borrmann, Steffen, Schindler, Andreas, Issifou, Saadou, Adegnika, Ayola A, Matsiegui, Pierre-Blaise, Binder, Ronald, Lell, Bertrand, Wiesner, Jochen, Baranek, Thomas, Jomaa, Hassan, and Kremsner, Peter G

Subjects
Malaria -- Drug therapy, Antimalarials -- Evaluation
Published
2002

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