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16,466 results on '"INFLAMMATION"'

1. A Guide to the Top 15 Antibiotics for Dogs: What you should know about the antibiotics your veterinarian prescribed for your dog

Author

Bailey, Jennifer

Subjects
Inflammation, Dogs, Pain -- Care and treatment, Analgesics -- Rankings, Antibiotics -- Rankings, Zoology and wildlife conservation
Abstract

Pain medications for dogs can be divided into two broad categories: nonsteroidal anti-inflammatory drugs (NSAIDs), which alleviate pain by reducing inflammation, and analgesics, which provide pain relief through a variety [...]

Published
2024

2. Intercellular interaction between [FAP.sup.+] fibroblasts and [CD150.sup.+] inflammatory monocytes mediates fibrostenosis in Crohn's disease

Author

Ke, Bo-Jun, Abdurahiman, Saeed, Biscu, Francesca, Zanella, Gaia, Dragoni, Gabriele, Santhosh, Sneha, De Simone, Veronica, Zouzaf, Anissa, van Baarle, Lies, Stakenborg, Michelle, Bosakova, Veronika, Van Rymenant, Yenti, Verhulst, Emile, Verstockt, Sare, Klein, Elliott, Bislenghi, Gabriele, Wolthuis, Albert, Fric, Jan, Breynaert, Christine, D'Hoore, Andre, Van der Veken, Pieter, De Meester, Ingrid, Lovisa, Sara, Hawinkels, Lukas J.A.C., Verstockt, Bram, De Hertogh, Gert, Vermeire, Severine, and Matteoli, Gianluca

Subjects
R and D Systems, Boehringer Ingelheim Pharmaceuticals Inc., Computer software industry, Inflammation, Collagen, B cells, Gastrointestinal diseases, Pharmaceutical industry, Health care industry
Abstract

Crohn's disease (CD) is marked by recurring intestinal inflammation and tissue injury, often resulting in fibrostenosis and bowel obstruction, necessitating surgical intervention with high recurrence rates. To elucidate the mechanisms underlying fibrostenosis in CD, we analyzed the transcriptome of cells isolated from the transmural ileum of patients with CD, including a trio of lesions from each patient: non-affected, inflamed, and stenotic ileum samples, and compared them with samples from patients without CD. Our computational analysis revealed that profibrotic signals from a subset of monocyte- derived cells expressing CD150 induced a disease-specific fibroblast population, resulting in chronic inflammation and tissue fibrosis. The transcription factor TWIST1 was identified as a key modulator of fibroblast activation and extracellular matrix (ECM) deposition. Genetic and pharmacological inhibition of TWIST1 prevents fibroblast activation, reducing ECM production and collagen deposition. Our findings suggest that the myeloid-stromal axis may offer a promising therapeutic target to prevent fibrostenosis in CD., Introduction Crohn's disease (CD) is a chronic inflammatory condition affecting the gastrointestinal tract, characterized by transmural inflammation that often leads to complications such as strictures, fistulas, and abscesses. The disease [...]

Published
2024
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6. Health trends The lowdown on inflammation

Subjects
Inflammation, Convenience foods
Abstract

Features / Health trends INFLAMMATION Health trends The lowdown on inflammation Everyone’s talking about it, but do we need to worry about inflammation when following a vegan diet? Linda Tyler [...]

Published
2024

7. 3 WAYS TO FIGHT INFLAMMATION

Subjects
Inflammation
Abstract

FOOD / Snuff out inflammation 3 WAYS TO FIGHT INFLAMMATION Plant-based solutions to dampen down chronic inflammation. 1 GUT HEALTH FIRST Your gut is central to so many aspects of [...]

Published
2024

8. SNUFF OUT INFLAMMATION

Subjects
Inflammation, Chronic diseases
Abstract

FOOD & DRINK | LOW CARB LOW CARB LIVING SNUFF OUT INFLAMMATION Inflammation can cause aches and pains, chronic disease and premature ageing, says functional nutritionist, Pauline Cox MSc. She [...]

Published
2024

12. CytoDyn engages CRO for Phase II inflammation trial

Subjects
Inflammation, Business, News, opinion and commentary
Abstract

CytoDyn has engaged Syneos Health as the contract research organization for its upcoming Phase II study exploring leronlimab and its effects on chronic [...]

Published
2024

14. Data on Central Nervous System Depressants Discussed by Researchers at Soochow University (Paravertebrally-injected Multifunctional Hydrogel for Sustained Anti-inflammation and Pain Relief In Lumbar Disc Herniation)

Subjects
Inflammation, Central nervous system depressants, Pain -- Care and treatment, Physical fitness, Central nervous system
Abstract

2024 AUG 10 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators publish new report on Drugs and Therapies - Central Nervous System […]

Published
2024

15. Blocking IL-11 Gene Reduces Inflammation So Mice Live 24% Longer and Healthier

Subjects
Inflammation, Mice, Consumer news and advice, General interest
Abstract

(https://www.nature.com/articles/s41586-024-07701-9) Inhibition of IL-11 signalling extends mammalian healthspan and lifespan- Nature Female Il11-deleted mice are protected from age-associated obesity, frailty, and metabolic decline. Male mice lives 22.5% longer and female [...]

Published
2024

17. Reports from Wenzhou Medical University Describe Recent Advances in Antibiotics (Dextran-based Antibacterial Hydrogel Dressings for Accelerating Infected Wound Healing By Reducing Inflammation Levels)

Subjects
Dextran, Inflammation, Bacterial infections, Infection, Antibacterial agents, Physical fitness, Health
Abstract

2024 JUL 6 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Data detailed on Drugs and Therapies - Antibiotics have been presented. According [...]

Published
2024

19. 5 Foods That Can Help Reduce Inflammation

Subjects
Inflammation, Anti-inflammatory diet, Business, international
Abstract

Feeling tired all the time, your skin is acting up, and can't sleep? Then maybe you're dealing with body inflammation. Inflammation is your body's natural response to injury, damaged cells, [...]

Published
2024

20. Tongde Hospital Zhejiang Province Researchers Provide New Insights into Colitis (Atox1 regulates macrophage polarization in intestinal inflammation via ROS-NLRP3 inflammasome pathway)

Subjects
Medical research, Medicine, Experimental, Inflammation, Colitis, Macrophages, Gastrointestinal diseases, Physical fitness, Health
Abstract

2024 JUN 15 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Researchers detail new data in colitis. According to news originating from the [...]

Published
2024

21. Research Results from Umm Al-Qura University Update Understanding of Glioblastomas (Targeting inflammation in glioblastoma: An updated review from pathophysiology to novel therapeutic approaches)

Subjects
Inflammation, Brain tumors, Glioblastoma multiforme, Physical fitness, Health, Umm Al-Qura University
Abstract

2024 JUN 15 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Research findings on glioblastomas are discussed in a new report. According to [...]

Published
2024

23. Birjand University of Medical Sciences Researchers Update Knowledge of Apoptosis (Protective effect of hesperidin on malathion-induced ovarian toxicity in mice: The role of miRNAs, inflammation, and apoptosis)

Subjects
Women -- Health aspects, Inflammation, MicroRNA, Apoptosis, Malathion, Health, Women's issues/gender studies
Abstract

2024 JUN 13 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- Fresh data on apoptosis are presented in a new report. According to news reporting [...]

Published
2024

26. Feel-great inflammation remedy: laughter

Subjects
Inflammation, Wit and humor, Stress (Psychology), Business, Business, international
Abstract

—Melissa Gotthardt Chuckling at your favorite sitcom sends inflammation plunging in 20 minutes, according to a study from Loma Linda University. The researchers also found that viewing comedies for 20 [...]

Published
2024

27. Investigators from Yale University School of Medicine Have Reported New Data on Chorioamnionitis (Tlr8-activating Mir-146a-3p Is an Intermediate Signal Contributing To Fetal Membrane Inflammation In Response To Bacterial Lps)

Subjects
Women -- Health aspects, Inflammation, Infants (Premature), Health, Women's issues/gender studies, Yale University. School of Medicine
Abstract

2024 MAY 16 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- Research findings on Pregnancy Complications - Chorioamnionitis are discussed in a new report. According [...]

Published
2024

28. Scientists at Feinstein Institutes find ultrasound neuromodulation promises to treat pulmonary hypertension

Subjects
Medical research, Medicine, Experimental, Inflammation, Scientists, Pulmonary hypertension, Pharmaceuticals and cosmetics industries
Abstract

Bioelectronic medicine scientists at The Feinstein Institutes for Medical Research used noninvasive, splenic focused ultrasound stimulation (sFUS) and found they can reduce inflammation and improve symptoms of pulmonary arterial hypertension [...]

Published
2024

30. Circadian desynchronization desensitizes insulin-producing cells to cytokine-mediated transcriptomic remodeling and cell death: a novel beta-cell anti-apoptotic response to inflammation

Subjects
Biochemistry, Cytokines, Inflammation, Pancreatic beta cells, Insulin, Apoptosis, Cells, Physical fitness, Health
Abstract

2024 MAY 4 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

Published
2024

32. Data on Toxicology Described by a Researcher at University of North Carolina Chapel Hill (Emissions from plastic incineration induce inflammation, oxidative stress, and impaired bioenergetics in primary human respiratory epithelial cells)

Subjects
Inflammation, Physical fitness, Health, University of North Carolina
Abstract

2024 APR 20 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Current study results on toxicology have been published. According to news reporting [...]

Published
2024

35. University of Arkansas for Medical Sciences Researcher Provides New Data on Obesity (Soy Protein Concentrate Diets Inversely Affect LPS-Binding Protein Expression in Colon and Liver, Reduce Liver Inflammation, and Increase Fecal LPS Excretion ...)

Subjects
Biochemistry, Obesity, Inflammation, Protein binding, Anti-inflammatory diet, Isoflavones, Physical fitness, Health
Abstract

2024 APR 20 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Fresh data on obesity are presented in a new report. According to [...]

Published
2024

36. Data on Science Reported by Researchers at Huazhong University of Science and Technology (Expression of USP25 associates with fibrosis, inflammation and metabolism changes in IgG4-related disease)

Subjects
Fibrosis, Inflammation, B cells, Immunoglobulin G, Physical fitness, Health
Abstract

2024 APR 13 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators publish new report on science. According to news reporting from Huazhong [...]

Published
2024

39. p40 homodimers bridge ischemic tissue inflammation and heterologous alloimmunity in mice via IL-15 transpresentation

Author

Tsuda, Hidetoshi, Keslar, Karen S., Baldwin, William M., III, Heeger, Peter S., Valujskikh, Anna, and Fairchild, Robert L.

Subjects
Thermo Fisher Scientific Inc., Scientific equipment and supplies industry, T cells, Inflammation, Immune response, Antigens, Heart -- Transplantation, Health care industry
Abstract

Virus-induced memory T cells often express functional cross-reactivity, or heterologous immunity, to other viruses and to allogeneic MHC molecules that is an important component of pathogenic responses to allogeneic transplants. During immune responses, antigen-reactive naive and central memory T cells proliferate in secondary lymphoid organs to achieve sufficient cell numbers to effectively respond, whereas effector memory T cell proliferation occurs directly within the peripheral inflammatory microenvironment. Mechanisms driving heterologous memory T cell proliferation and effector function expression within peripheral tissues remain poorly understood. Here, we dissected proliferation of heterologous donor-reactive memory [CD8.sup.+] T cells and their effector functions following infiltration into heart allografts with low or high intensities of ischemic inflammation. Proliferation within both ischemic conditions required p40 homodimer-induced IL-15 transpresentation by graft DCs, but expression of effector functions mediating acute allograft injury occurred only in high-ischemic allografts. Transcriptional responses of heterologous donor-reactive memory [CD8.sup.+] T cells were distinct from donor antigen-primed memory [CD8.sup.+] T cells during early activation in allografts and at graft rejection. Overall, the results provide insights into mechanisms driving heterologous effector memory [CD8.sup.+] T cell proliferation and the separation between proliferation and effector function that is dependent on the intensity of inflammation within the tissue microenvironment., Introduction Effective adaptive immune responses require the proliferation and expression of effector function by the limited number of antigen-reactive lymphocyte clones to achieve the numbers needed to mediate the response. [...]

Published
2024
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40. Multiomic profiling reveals metabolic alterations mediating aberrant platelet activity and inflammation in myeloproliferative neoplasms

Author

He, Fan, Laranjeira, Angelo B.A., Kong, Tim, Lin, Shuyang, Ashworth, Katrina J., Liu, Alice, Lasky, Nina M., Fisher, Daniel A.C., Cox, Maggie J., Fulbright, Mary C., Antunes-Heck, Lilian, Yu, LaYow, Brakhane, Molly, Gao, Bei, Sykes, Stephen M., D'Alessandro, Angelo, Di Paola, Jorge, and Oh, Stephen T.

Subjects
Tumors, Inflammation, Health care industry, Washington University. School of Medicine
Abstract

Platelets from patients with myeloproliferative neoplasms (MPNs) exhibit a hyperreactive phenotype. Here, we found elevated P-selectin exposure and platelet-leukocyte aggregates indicating activation of platelets from essential thrombocythemia (ET) patients. Single-cell RNA-seq analysis of primary samples revealed significant enrichment of transcripts related to platelet activation, mTOR, and oxidative phosphorylation in ET patient platelets. These observations were validated via proteomic profiling. Platelet metabolomics revealed distinct metabolic phenotypes consisting of elevated ATP generation accompanied by increases in the levels of multiple intermediates of the tricarboxylic acid cycle, but lower a-ketoglutarate ([alpha]-KG) in MPN patients. Inhibition of PI3K/AKT/mTOR signaling significantly reduced metabolic responses and hyperreactivity in MPN patient platelets, while [alpha]-KG supplementation markedly reduced oxygen consumption and ATP generation. Ex vivo incubation of platelets from both MPN patients and Jak2 V617F-knockin mice with [alpha]-KG supplementation significantly reduced platelet activation responses. Oral [alpha]-KG supplementation of Jak2 V617Fmice decreased splenomegaly and reduced hematocrit, monocyte, and platelet counts. Finally, [alpha]- KG treatment significantly decreased proinflammatory cytokine secretion from MPN [CD14.sup.+] monocytes. Our results reveal a previously unrecognized metabolic disorder in conjunction with aberrant PI3K/AKT/mTOR signaling that contributes to platelet hyperreactivity in MPN patients., Introduction Philadelphia-negative chronic myeloproliferative neoplasms (MPNs), including polycythemia vera (PV), essential thrombocythemia (ET), and myelofibrosis (MF), are clonal hematopoietic disorders characterized by overproduction of mature blood cells such as erythrocytes, [...]

Published
2024
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41. DNA methylation-mediated Rbpjk suppression protects against fracture nonunion caused by systemic inflammation

Author

Xiao, Ding, Fang, Liang, Liu, Zhongting, He, Yonghua, Ying, Jun, Qin, Haocheng, Lu, Aiwu, Shi, Meng, Li, Tiandao, Zhang, Bo, Guan, Jianjun, Wang, Cuicui, Abu-Amer, Yousef, and Shen, Jie

Subjects
DNA, RNA sequencing, Methylation, Inflammation, Genetic engineering, RNA, Methyltransferases, Epigenetic inheritance, Health care industry, Washington University. School of Medicine
Abstract

Challenging skeletal repairs are frequently seen in patients experiencing systemic inflammation. To tackle the complexity and heterogeneity of the skeletal repair process, we performed single-cell RNA sequencing and revealed that progenitor cells were one of the major lineages responsive to elevated inflammation and this response adversely affected progenitor differentiation by upregulation of Rbpjk in fracture nonunion. We then validated the interplay between inflammation (via constitutive activation of Ikk2, Ikk2ca) and Rbpjk specifically in progenitors by using genetic animal models. Focusing on epigenetic regulation, we identified Rbpjk as a direct target of Dnmt3b. Mechanistically, inflammation decreased Dnmt3b expression in progenitor cells, consequently leading to Rbpjk upregulation via hypomethylation within its promoter region. We also showed that Dnmt3b loss-of-function mice phenotypically recapitulated the fracture repair defects observed in Ikk2ca- transgenic mice, whereas Dnmt3b-transgenic mice alleviated fracture repair defects induced by Ikk2ca. Moreover, Rbpjk ablation restored fracture repair in both Ikk2ca mice and Dnmt3b loss-of-function mice. Altogether, this work elucidates a common mechanism involving a NF-[kappa]B/Dnmt3b/Rbpjk axis within the context of inflamed bone regeneration. Building on this mechanistic insight, we applied local treatment with epigenetically modified progenitor cells in a previously established mouse model of inflammation-mediated fracture nonunion and showed a functional restoration of bone regeneration under inflammatory conditions through an increase in progenitor differentiation potential., Introduction Under most circumstances, bone fractures regenerate with full restoration of tissue morphometry and mechanical strength in the absence of scar formation. Nonetheless, approximately 5% to 10% of fractures globally [...]

Published
2024
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42. Breakfast 'superfood' reduces inflammation and can be made into a smoothie; An occupational therapist and pharmacists have outlined the foods that can help reduce joint pain and stiffness

Subjects
Arthralgia, Pharmacists, Rheumatoid factor, Inflammation, Pain -- Care and treatment, Osteoarthritis, General interest, News, opinion and commentary
Abstract

Byline: By, Steven Smith Arthritis is a condition that can be physically and emotionally challenging, affecting an estimated 10 million people in the UK, including adults and children. For those [...]

Published
2024

43. MINISTRY OF HEALTH invites tenders for Painkilling and Anti-Inflammation Pills

Subjects
Inflammation, News, opinion and commentary
Abstract

MINISTRY OF HEALTH, Kuwait has invited tenders for Painkilling and Anti-Inflammation Pills. Tender Notice No: 4TB271 Deadline: September 20, 2024 Copyright © 2011-2022 pivotalsources.com. All rights reserved. Provided by SyndiGate [...]

Published
2024

45. Dad left permanently hunched over in agony due to crippling condition; Jonathan Johnson, 35, has been left permanently bent double and unable to even lift his head due to excruciating ligament inflammation in his spine that has no cure

Subjects
Inflammation, Physically disabled persons, General interest, News, opinion and commentary
Abstract

Byline: By, Douglas Whitbread & Rom Preston-Ellis A dad-of-four has been left permanently hunched over due to a crippling condition that means he can't straighten his spine. Jonathan Johnson, 35, [...]

Published
2024

46. GERMAN INSTITUTE FOR NUTRITIONAL RESEARCH invites tenders for Proteomics Analysis in Plasma Samples Using Olink(R) Explore 384 Cardiometabolic and Olink(R) Explore 384 Inflammation

Subjects
Inflammation, Proteomics, News, opinion and commentary
Abstract

GERMAN INSTITUTE FOR NUTRITIONAL RESEARCH, Germany has invited tenders for Proteomics Analysis in Plasma Samples Using Olink(R) Explore 384 Cardiometabolic and Olink(R) Explore 384 Inflammation. Tender Notice No: 405088-2024 Deadline: [...]

Published
2024

47. 'Superstar' nutrient accelerates weight loss and reduces inflammation; Dieticians say that one key part of food is the secret to cutting a condition a third of adults have, which is responsible for weight gain and high blood sugar levels

Subjects
Inflammation, Anti-inflammatory diet, Blood sugar, Adults, Hyperglycemia, Weight loss, Hypertension, General interest, News, opinion and commentary
Abstract

Byline: By, Neil Shaw Nutrition experts have revealed that a specific component of food could be the secret weapon against metabolic syndrome, a condition affecting one in three adults and [...]

Published
2024

48. Grisly details of how space impacts bodies revealed from mutating DNA to 'blood destruction'; Space travel was found to increase levels of inflammation in the blood, and produce more exertion from leg muscles, with differing effects on the body depending on gender

Subjects
Gene mutations, DNA, Inflammation, Outer space -- Discovery and exploration, General interest, News, opinion and commentary
Abstract

Byline: By, Emilia Randall A study has revealed thatspace can wreak havoc on the body, including on blood, cells and the immune system. The study gathered information from the SpaceX [...]

Published
2024

49. Nutritionist shares 'best supplement' to help joint pain and inflammation -but with a warning; One nutritionist is looking to ease the burden on Brits' joints with one natural potent supplement that has been a top choice for pain relief for centuries

Subjects
Arthralgia, Inflammation, General interest, News, opinion and commentary
Abstract

Byline: By, Samantha Leathers Lead nutritionist behind Dr Vegan, Shona Wilkinson, is urging Britons to turn to one tried-and-tested natural supplement to ease their joint pain and inflammation. The expert [...]

Published
2024

50. Nutrition expert's superfoods to give you clear, glowing skin; Dr Federica Amati said what people eat has a big impact on your complexion -and inflammation could result in acne and eczema

Subjects
Olive oil, Microbiota (Symbiotic organisms), Inflammation, Skin, Acne, Personal appearance, General interest, News, opinion and commentary
Abstract

Byline: By, Ben Hurst A nutritional expert has explained which 'superfoods' people need to eat to get a clear, glowing skin. Dr Federica Amati who is the chief nutritionist for [...]

Published
2024

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