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2 results on '"Hirawa, Nobuhito"'

1. Adenosine A1 receptor and its gene expression in ventricles from spontaneously hypertensive rats

Author

Kobayashi, Shun-Ichi, Umemura, Satoshi, Toya, Yoshiyuki, Hirawa, Nobuhito, Hayashi, Shuuichi, Uchino, Kazuaki, and Ishii, Masao

Subjects
Rats -- Physiological aspects, Adenosine -- Physiological aspects, Heart -- Physiological aspects, Biological sciences
Abstract

Gene expression of the adenosine A1 receptor, which provides cardioprotection against myocardial ischemia and reperfusion, was investigated in ventricles of 6- and 13-week-old Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR). Receptor mRNA levels was similar for both groups at 13 weeks, but was higher in SHR than WKY at 6 weeks. Plasma adenosine levels were higher in SHR at 13 weeks. The differences in mRNA expression levels were attributed to desensitization of the receptors during ischemia.

Published
1996

2. Effects of losartan and amlodipine on urinary albumin excretion and ambulatory blood pressure in hypertensive type 2 diabetic patients with overt nephropathy

Author

Yasuda, Gen, Ando, Daisaku, Hirawa, Nobuhito, Umemura, Satoshi, and Tochikubo, Osamu

Subjects
Losartan -- Dosage and administration, Type 2 diabetes -- Drug therapy, Amlodipine -- Dosage and administration, Health, Drug therapy, Dosage and administration
Abstract

Editor's comment: The editorial committee of Diabetes Care had some ethical concerns about potentially leaving patients for up to 24 weeks with blood pressure between 140/90 and 200/110 mmHg. After [...]

Published
2005

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