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1. DNA binding and heteromerization of the Drosophila transcription factor chorion factor 1/ultraspiracle

Author

Christianson, Anastasia M. Khoury, King, Dennis L., Hatzivassiliou, Evie, Casas, Jorge E., Hellenbeck, Paul L., Nikodem, Vera M., Mitsialis, S. Alex, and Kafatos, F.C.

Subjects
Drosophila -- Physiological aspects, Genetic transcription -- Regulation, DNA binding proteins -- Identification and classification, Science and technology
Abstract

The in vitro DNA-binding properties and distribution of the Drosophila chorion factor 1/ultraspiracle transcription factor (CF1/USP) were investigated. The study protocol involved the use of monoclonal antibodies and bacterially produced full-length protein. The results showed that CF1/USP bindsmoderately strongly to a single hormone response element half-site. However, the factor also forms heteromers with mammalian retinoic acid and thyroid receptors via a second half-site. It was suggested that the factor functions asa heterodimer in vivo, although its partner or partners have not yet been identified.

Published
1992

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