Search

Your search keyword '"Goodlad, R."' showing total 5 results
Start Over Author "Goodlad, R." Database Gale General OneFile
5 results on '"Goodlad, R."'

1. Gastrointestinal cell proliferation and crypt fission are separate but complementary means of increasing tissue mass following infusion of epidermal growth factor in rats

Author

Berlanga-Acosta, J, Playford, R J., Mandir, N, and Goodlad, R A.

Subjects
Cell proliferation -- Physiological aspects, Gastrointestinal system -- Physiological aspects, Epidermal growth factor -- Physiological aspects, Health, Physiological aspects
Abstract

Abstract Background and aims--Epidermal growth factor (EGF) is a potent mitogen for the gastrointestinal tract and also influences the number of new crypts formed by crypt fission. The time course [...]

Published
2001

2. Dietary fibre and the risk of colorectal cancer

Author

GOODLAD, R A.

Subjects
High-fiber diet -- Health aspects, Fiber in human nutrition -- Health aspects, Colorectal cancer -- Prevention, Health, Prevention, Health aspects
Abstract

It has long been accepted that a high fibre diet is a 'good thing' and protects against colon cancer: however, recently there has been a spate of extensive, studies, published [...]

Published
2001

3. NOT ALL DIETARY FIBRES ARE EQUAL: SELECTION OF POTENTIAL CANCER-PREVENTATIVE FIBRES BY INHIBITION OF GALACTOSE-BINDING LECTINS

Author

Singh, R., Englyst, H., Campbell, B., Fitzgerald, A., Goodlad, R., and Rhodes, J.

Subjects
Gastrointestinal diseases -- Research, Health, Research
Abstract

H. Englyst [1] A. Fitzgerald [2] R. Goodlad [2] Dept of Medicine University of Liverpool, Liverpool L69 3GA (1.) Carbohydrate Laboratory, University of Southampton Southampton S017 IB); (2.) Histopathology Unit [...]

Published
2001

4. Glucagon-like peptide-2 increases sucrase-isomaltase but not caudal-related homeobox protein-2 gene expression

Author

KITCHEN, P. A., FITZGERALD, A. J., GOODLAD, R. A., BARLEY, N. F., GHATEI, M. A., LEGON, S., BLOOM, S. R., PRICE, A., WALTERS, J. R. F., and FORBES, A.

Subjects
Peptides -- Analysis, Gene expression -- Analysis, Cell proliferation -- Analysis, Jejunum -- Evaluation, Ileum -- Evaluation, Biological sciences
Abstract

Kitchen, P. A., A. J. Fitzgerald, R. A. Goodlad, N. F. Barley, M. A. Ghatei, S. Legon, S. R. Bloom, A. Price, J. R. F. Walters, and A. Forbes. Glucagon-like peptide-2 increases sucrase-isomaltase but not caudal-related homeobox protein-2 gene expression. Am. J. Physiol. Gastrointest. Liver Physiol. 278: G425-G428, 2000.--To determine the effect of glucagon-like peptide-2 (GLP-2) on sucrase-isomaltase and caudal-related homeobox protein-2 (Cdx-2) gene expression, male Wistar rats were divided into total parenteral nutrition (TPN)-fed and GLP-2-treated, TPN-fed groups. TPN was given via a jugular line, inserted under anesthesia, for 7 days. The treatment group received 40 [micro]/day of GLP-2 intravenously with the TPN diet. The small intestine and colon were weighed and measured. Tissue was obtained from the jejunum, terminal ileum, and midcolon. RNA analysis, morphometry, and microdissection were performed. The weight of the small intestine of GLP-2-treated rats was greater than that of TPN-fed rats (P [is less than] 0.001). GLP-2 increased the mean metaphase arrests/crypt in both the jejunum and ileum (P [is less than] 0.001). Ileal expression of sucrase-isomaltase was increased by 1.6-fold (P [is less than] 0.05). Jejunal expression was increased by a similar amount, although not significantly (P = 0.08). There was no change in Cdx-2 gene expression. Thus GLP-2 can maintain small intestinal morphology and function, but effects on gene expression are not mediated by gross changes in the level of the mRNA for the homeobox protein Cdx-2. total parenteral nutrition; cellular proliferation; jejunum; ileum.

Published
2000

5. Social exclusion: in what sense a planning problem?

Author

Turok, I., Kearns, A., and Goodlad, R.

Subjects
Central planning -- Social aspects, Land use -- Social aspects, Marginality, Social -- Economic aspects, Architecture and design industries, Business, Business, international
Abstract

The issue of social exclusion has been little discussed in the field of planning, although it is included in other areas, such as education, social policy, health, housing and regeneration. The significance of social exclusion for planning is assessed and five dimensions of exclusion pertinent to planning are identified, including quality of life, low income and involvement in consumption activities, and participation in local decision making. It is suggested that a National Spatial Planning Framework could provide valuable information on a coherent spatial perspective.

Published
1999

Catalog

Books, media, physical & digital resources
See catalog results